Gastrointestinal diseases and their impact on drug solubility: Ulcerative Colitis

For poorly soluble compounds, drug product performance in patients with Ulcerative Colitis (UC) compared to healthy subjects can be affected due to differences in drug solubility in GI fluids. A risk assessment tool was developed to identify compounds with a high risk of altered solubility in the GI...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2020-09, Vol.152, p.105458-105458, Article 105458
Hauptverfasser:	Effinger, Angela, M O'Driscoll, Caitriona, McAllister, Mark, Fotaki, Nikoletta
Format:	Artikel
Sprache:	eng
Schlagworte:	Biorelevant media Gastrointestinal diseases Inflammatory Bowel Disease Physicochemical properties Solubility Ulcerative Colitis
Online-Zugang:	Volltext
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