Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening

•We identified a 7I superagonist mutant of the NS4b214-22 Yellow Fever virus epitope.•This LLW-7I mutant was found by combinatorial peptide library screening on the NN5048 CD8 T cell clone.•The LLW-7I mutation increases T cell function yet does not impact the monomeric off-rate.•Our modeling suggest...

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Veröffentlicht in:	Molecular immunology 2020-09, Vol.125, p.43-50
Hauptverfasser:	Bovay, Amandine, Zoete, Vincent, Rizkallah, Pierre J., Beck, Konrad, Delbreil, Philippe, Speiser, Daniel E., Cole, David K., Fuertes Marraco, Silvia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Altered peptide ligand Antigen sensitivity CD8 T cells Peptide rigidity Yellow fever virus
Online-Zugang:	Volltext
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