Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy
Mycobacterium leprae infection depends on the competence of the host immune defense to induce effective protection against this intracellular pathogen. The present study investigated the serum levels of vitamin D and the antimicrobial peptide cathelicidin, to determine the statistical correlation be...
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| Veröffentlicht in: | Microbial pathogenesis 2020-10, Vol.147, p.104373-104373, Article 104373 |
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| creator | Grossi de Oliveira, Ana Laura Chaves, Ana Thereza Santos Cardoso, Mariana Gomide Pinheiro, Guilherme Rafael Parreiras de Jesus, Augusto César de Faria Grossi, Maria Aparecida Lyon, Sandra Lacerda Bueno, Lilian da Costa Rocha, Manoel Otávio Toshio Fujiwara, Ricardo Alves da Silva Menezes, Cristiane |
| description | Mycobacterium leprae infection depends on the competence of the host immune defense to induce effective protection against this intracellular pathogen. The present study investigated the serum levels of vitamin D and the antimicrobial peptide cathelicidin, to determine the statistical correlation between them in leprosy patients before and post-six months of multidrug therapy (MDT), household contacts, and healthy individuals. Previous studies associated these molecules with high risks to develop mycobacterial diseases, such as tuberculosis and leprosy. A total of 34 leprosy patients [paucibacillary (n = 14), multibacillary (n = 20)], and 25 household contacts were recruited. Eighteen healthy adults were selected as a control group. Serum concentrations of vitamin D (25(OH)VD3) and cathelicidin were measured using high-performance liquid chromatography (HPLC), and an enzyme-linked immunosorbent assay (ELISA) kit, respectively. There were no significant differences in serum levels of 25(OH)VD3 between all groups, and the overall prevalence rate of vitamin D deficiency was 67.1%. Cathelicidin levels were significantly lower in both untreated and treated patients when compared to controls and household contacts (p |
| doi_str_mv | 10.1016/j.micpath.2020.104373 |
| format | Article |
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•Correlation between Vitamin D and cathelicidin levels in leprosy patients was investigated.•Vitamin D deficiency was detected in the majority of analyzed individuals.•Cathelicidin serum levels were significantly lower in leprosy patients.•Hypovitaminosis D and low cathelicidin levels are correlated in leprosy patients.•Vitamin D supplementation could strengthen the immune response against leprosy.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2020.104373</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Cathelicidin ; Leprosy ; Leprosy drug therapy ; M. leprae ; Vitamin D3</subject><ispartof>Microbial pathogenesis, 2020-10, Vol.147, p.104373-104373, Article 104373</ispartof><rights>2020 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-36322a2a067108995edad63b2c3d43d13f1289b17e657aa930b5a9346a2613753</citedby><cites>FETCH-LOGICAL-c342t-36322a2a067108995edad63b2c3d43d13f1289b17e657aa930b5a9346a2613753</cites><orcidid>0000-0002-4351-5835 ; 0000-0003-4614-7502 ; 0000-0002-4713-575X ; 0000-0002-4721-1767 ; 0000-0002-8343-8344</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2020.104373$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Grossi de Oliveira, Ana Laura</creatorcontrib><creatorcontrib>Chaves, Ana Thereza</creatorcontrib><creatorcontrib>Santos Cardoso, Mariana</creatorcontrib><creatorcontrib>Gomide Pinheiro, Guilherme Rafael</creatorcontrib><creatorcontrib>Parreiras de Jesus, Augusto César</creatorcontrib><creatorcontrib>de Faria Grossi, Maria Aparecida</creatorcontrib><creatorcontrib>Lyon, Sandra</creatorcontrib><creatorcontrib>Lacerda Bueno, Lilian</creatorcontrib><creatorcontrib>da Costa Rocha, Manoel Otávio</creatorcontrib><creatorcontrib>Toshio Fujiwara, Ricardo</creatorcontrib><creatorcontrib>Alves da Silva Menezes, Cristiane</creatorcontrib><title>Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy</title><title>Microbial pathogenesis</title><description>Mycobacterium leprae infection depends on the competence of the host immune defense to induce effective protection against this intracellular pathogen. The present study investigated the serum levels of vitamin D and the antimicrobial peptide cathelicidin, to determine the statistical correlation between them in leprosy patients before and post-six months of multidrug therapy (MDT), household contacts, and healthy individuals. Previous studies associated these molecules with high risks to develop mycobacterial diseases, such as tuberculosis and leprosy. A total of 34 leprosy patients [paucibacillary (n = 14), multibacillary (n = 20)], and 25 household contacts were recruited. Eighteen healthy adults were selected as a control group. Serum concentrations of vitamin D (25(OH)VD3) and cathelicidin were measured using high-performance liquid chromatography (HPLC), and an enzyme-linked immunosorbent assay (ELISA) kit, respectively. There were no significant differences in serum levels of 25(OH)VD3 between all groups, and the overall prevalence rate of vitamin D deficiency was 67.1%. Cathelicidin levels were significantly lower in both untreated and treated patients when compared to controls and household contacts (p < 0.05). Strong correlations between hypovitaminosis D and reduced cathelicidin in untreated (r = 0.86) and post-six months of MDT (r = 0.79) leprosy patients were observed. These results suggest that vitamin D status and cathelicidin levels are strongly correlated during multidrug therapy for leprosy and nutritional supplementation from the beginning of treatment could strengthen the immune response against leprosy.
•Correlation between Vitamin D and cathelicidin levels in leprosy patients was investigated.•Vitamin D deficiency was detected in the majority of analyzed individuals.•Cathelicidin serum levels were significantly lower in leprosy patients.•Hypovitaminosis D and low cathelicidin levels are correlated in leprosy patients.•Vitamin D supplementation could strengthen the immune response against leprosy.</description><subject>Cathelicidin</subject><subject>Leprosy</subject><subject>Leprosy drug therapy</subject><subject>M. leprae</subject><subject>Vitamin D3</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE1PwzAMhiMEEmPwE5By5NKRjzZtTwiNjyFN4gLnyEu8kalfJClS_z0Z252LLVuvX9sPIbecLTjj6n6_aJ0ZIH4tBBOHXi5LeUZmnNUq44JV52TGqkpkOePsklyFsGeM1bmsZ6RfTUP_4yK0ruuDC_SJQmepRzsatNQkV2yccdZ1FDzSEH3f7ZqJmt57bCAmkR2963Y0KWk7NtFZP_5VHoaJwg5cFyJtcPB9mK7JxRaagDenPCefL88fy1W2fn99Wz6uMyNzETOppBAggKmSs6quC7RgldwII20uLZdbLqp6w0tURQlQS7YpUswVCMVlWcg5uTv6pq3fI4aoWxcMNg102I9Bi1xIpvIypTkpjlKTDgwet3rwrgU_ac70AbDe6xNgfQCsj4DT3MNxDtMfPw69DsZhl7A5jyZq27t_HH4BHceIFg</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Grossi de Oliveira, Ana Laura</creator><creator>Chaves, Ana Thereza</creator><creator>Santos Cardoso, Mariana</creator><creator>Gomide Pinheiro, Guilherme Rafael</creator><creator>Parreiras de Jesus, Augusto César</creator><creator>de Faria Grossi, Maria Aparecida</creator><creator>Lyon, Sandra</creator><creator>Lacerda Bueno, Lilian</creator><creator>da Costa Rocha, Manoel Otávio</creator><creator>Toshio Fujiwara, Ricardo</creator><creator>Alves da Silva Menezes, Cristiane</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4351-5835</orcidid><orcidid>https://orcid.org/0000-0003-4614-7502</orcidid><orcidid>https://orcid.org/0000-0002-4713-575X</orcidid><orcidid>https://orcid.org/0000-0002-4721-1767</orcidid><orcidid>https://orcid.org/0000-0002-8343-8344</orcidid></search><sort><creationdate>202010</creationdate><title>Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy</title><author>Grossi de Oliveira, Ana Laura ; Chaves, Ana Thereza ; Santos Cardoso, Mariana ; Gomide Pinheiro, Guilherme Rafael ; Parreiras de Jesus, Augusto César ; de Faria Grossi, Maria Aparecida ; Lyon, Sandra ; Lacerda Bueno, Lilian ; da Costa Rocha, Manoel Otávio ; Toshio Fujiwara, Ricardo ; Alves da Silva Menezes, Cristiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-36322a2a067108995edad63b2c3d43d13f1289b17e657aa930b5a9346a2613753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cathelicidin</topic><topic>Leprosy</topic><topic>Leprosy drug therapy</topic><topic>M. leprae</topic><topic>Vitamin D3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grossi de Oliveira, Ana Laura</creatorcontrib><creatorcontrib>Chaves, Ana Thereza</creatorcontrib><creatorcontrib>Santos Cardoso, Mariana</creatorcontrib><creatorcontrib>Gomide Pinheiro, Guilherme Rafael</creatorcontrib><creatorcontrib>Parreiras de Jesus, Augusto César</creatorcontrib><creatorcontrib>de Faria Grossi, Maria Aparecida</creatorcontrib><creatorcontrib>Lyon, Sandra</creatorcontrib><creatorcontrib>Lacerda Bueno, Lilian</creatorcontrib><creatorcontrib>da Costa Rocha, Manoel Otávio</creatorcontrib><creatorcontrib>Toshio Fujiwara, Ricardo</creatorcontrib><creatorcontrib>Alves da Silva Menezes, Cristiane</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grossi de Oliveira, Ana Laura</au><au>Chaves, Ana Thereza</au><au>Santos Cardoso, Mariana</au><au>Gomide Pinheiro, Guilherme Rafael</au><au>Parreiras de Jesus, Augusto César</au><au>de Faria Grossi, Maria Aparecida</au><au>Lyon, Sandra</au><au>Lacerda Bueno, Lilian</au><au>da Costa Rocha, Manoel Otávio</au><au>Toshio Fujiwara, Ricardo</au><au>Alves da Silva Menezes, Cristiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy</atitle><jtitle>Microbial pathogenesis</jtitle><date>2020-10</date><risdate>2020</risdate><volume>147</volume><spage>104373</spage><epage>104373</epage><pages>104373-104373</pages><artnum>104373</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Mycobacterium leprae infection depends on the competence of the host immune defense to induce effective protection against this intracellular pathogen. The present study investigated the serum levels of vitamin D and the antimicrobial peptide cathelicidin, to determine the statistical correlation between them in leprosy patients before and post-six months of multidrug therapy (MDT), household contacts, and healthy individuals. Previous studies associated these molecules with high risks to develop mycobacterial diseases, such as tuberculosis and leprosy. A total of 34 leprosy patients [paucibacillary (n = 14), multibacillary (n = 20)], and 25 household contacts were recruited. Eighteen healthy adults were selected as a control group. Serum concentrations of vitamin D (25(OH)VD3) and cathelicidin were measured using high-performance liquid chromatography (HPLC), and an enzyme-linked immunosorbent assay (ELISA) kit, respectively. There were no significant differences in serum levels of 25(OH)VD3 between all groups, and the overall prevalence rate of vitamin D deficiency was 67.1%. Cathelicidin levels were significantly lower in both untreated and treated patients when compared to controls and household contacts (p < 0.05). Strong correlations between hypovitaminosis D and reduced cathelicidin in untreated (r = 0.86) and post-six months of MDT (r = 0.79) leprosy patients were observed. These results suggest that vitamin D status and cathelicidin levels are strongly correlated during multidrug therapy for leprosy and nutritional supplementation from the beginning of treatment could strengthen the immune response against leprosy.
•Correlation between Vitamin D and cathelicidin levels in leprosy patients was investigated.•Vitamin D deficiency was detected in the majority of analyzed individuals.•Cathelicidin serum levels were significantly lower in leprosy patients.•Hypovitaminosis D and low cathelicidin levels are correlated in leprosy patients.•Vitamin D supplementation could strengthen the immune response against leprosy.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.micpath.2020.104373</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4351-5835</orcidid><orcidid>https://orcid.org/0000-0003-4614-7502</orcidid><orcidid>https://orcid.org/0000-0002-4713-575X</orcidid><orcidid>https://orcid.org/0000-0002-4721-1767</orcidid><orcidid>https://orcid.org/0000-0002-8343-8344</orcidid></addata></record> |
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| subjects | Cathelicidin Leprosy Leprosy drug therapy M. leprae Vitamin D3 |
| title | Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy |
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