Calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene mutations: a systematic review

Background Calcineurin inhibitor (CNI) use in genetic steroid-resistant nephrotic syndrome (SRNS) is controversial as response rate is reported to be lower than non-genetic disease and no plausible mechanism of action is known. Methods We reviewed PubMed for publications on CNI use in hereditary SRN...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2021-06, Vol.36 (6), p.1353-1364
Hauptverfasser:	Malakasioti, Georgia, Iancu, Daniela, Tullus, Kjell
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Calcineurin Calcineurin inhibitors Calcineurin Inhibitors - therapeutic use Child Dosage and administration Drug therapy Gene mutations Genetic analysis Genetic aspects Genotypes Health aspects Humans Kidney Kidney diseases Kidney glomerulus Kidneys Medicine Medicine & Public Health Mutation Nephrology Nephrotic syndrome Nephrotic Syndrome - drug therapy Nephrotic Syndrome - genetics Pathogenicity Pediatrics Phenotypes Podocytes Response rates Review Toxicity Urology
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