Are Fatty Acids Gluconeogenic Precursors?

It is widely accepted that the tricarboxylic acid (TCA) cycle is a critical partner for gluconeogenesis (GNG) in hepatocytes. Although researchers in the 1950s showed, using radiolabeled long-chain fatty acids, that acetate derived from fatty acid β-oxidation contributes carbon to glucose, fatty aci...

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Veröffentlicht in:	The Journal of nutrition 2020-09, Vol.150 (9), p.2235-2238
1. Verfasser:	Michael H, Green
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Biochemistry Carbon - metabolism Carbon cycle Carbon dioxide Citric acid Citric Acid Cycle - physiology Condensates Cytosol Efflux Fatty acids Fatty Acids - chemistry Fatty Acids - metabolism Gluconeogenesis Gluconeogenesis - physiology gluconeogenic precursors Glucose Glucose - biosynthesis Hepatocytes Humans Isotope studies Malate Mitochondria net gain Oxidation precursor Precursors TCA cycle Textbooks tracer studies Tricarboxylic acid cycle
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