p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine

Mechanistic target of rapamycin complex 1 (mTORC1) plays a pivotal role in controlling cell growth and metabolism in response to nutrients and growth factors. The activity of mTORC1 is dually regulated by amino acids and growth factor signaling, and amino acid-dependent mTORC1 activity is regulated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell Structure and Function 2020, Vol.45(2), pp.93-105
Hauptverfasser:	Ito, Shizuka, Nada, Shigeyuki, Yamazaki, Daisuke, Kimura, Tetsuya, Kajiwara, Kentaro, Miki, Hiroaki, Okada, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino acids Animals CDX2 protein CDX2 Transcription Factor - genetics CDX2 Transcription Factor - metabolism Cell differentiation Colon Epithelium Genetic analysis Goblet cells Goblet Cells - metabolism Growth factors Guanosine triphosphatases intestinal epithelium Intestine KLF4 protein Kruppel-Like Factor 4 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Lysosomes Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Membrane proteins Metabolism Mice Mice, Knockout mTORC1 Mucin Nutrients Organoids p18/lamtor1 Rapamycin Signal Transduction TOR protein Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!