Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation

Background Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79ma/ma mice harbor a mutation in the gene encoding Transmembrane Protein 79 (or Mattrin), which has previously been as...

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Veröffentlicht in:	Allergy (Copenhagen) 2020-12, Vol.75 (12), p.3216-3227
Hauptverfasser:	Saunders, Sean P., Floudas, Achilleas, Moran, Tara, Byrne, Ciara M., Rooney, Michael D., Fahy, Caoimhe M. R., Geoghegan, Joan A., Iwakura, Yoichiro, Fallon, Padraic G., Schwartz, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Asthma Atopic dermatitis cutaneous inflammation Dermatitis Dermatitis, Atopic - genetics Disease Models, Animal Eczema Helper cells Inflammation Interleukin-17 - genetics interleukin‐17A Lung diseases lung inflammation Lymphocytes T Membrane Proteins - genetics Mice Mutants Mutation Pneumonia - genetics Point mutation Respiratory tract diseases Skin skin barrier Skin diseases Tmem79
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