A visual framework to create photorealistic retinal vessels for diagnosis purposes

[Display omitted] •We propose an automatic tool to create photorealistic retinal vessels.•The methodology applies the principle of least action and Catmull-Rom interpolation.•The interface allows you to instantly modify the rendered image.•Possible applications include data augmentation and medical diagnosis.•Results are validated against public domain ground-truth. The methods developed in recent years for synthesising an ocular fundus can be been divided into two main categories. The first category of methods involves the development of an anatomical model of the eye, where artificial images are generated using appropriate parameters for modelling the vascular networks and fundus. The second type of method has been made possible by the development of deep learning techniques and improvements in the performance of hardware (especially graphics cards equipped with a large number of cores). The methodology proposed here to produce high-resolution synthetic fundus images is intended to be an alternative to the increasingly widespread use of generative adversarial networks to overcome the problems that arise in producing slightly modified versions of the same real images. This will allow the simulation of pathologies and the prediction of eye-related diseases. The proposed approach is based on the principle of least action and correctly places the vessels on the simulated eye fundus without using real morphometric information. An a posteriori analysis of the average characteristics such as the size, length, bifurcations, and endpoint positioning confirmed the substantial accuracy of the proposed approach compared to real data. A graphical user interface allows the user to make any changes in real time by controlling the positions of control points.