Borane‐Catalyzed Chemoselective and Enantioselective Reduction of 2‐Vinyl‐Substituted Pyridines

Herein, we report that highly chemoselective and enantioselective reduction of 2‐vinyl‐substituted pyridines has been achieved for the first time. The reaction, which uses chiral spiro‐bicyclic bisboranes as catalysts and HBpin and an acidic amide as reducing reagents, proceeds through a cascade pro...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-10, Vol.59 (42), p.18452-18456
Hauptverfasser:	Tian, Jun‐Jie, Yang, Zhao‐Ying, Liang, Xin‐Shen, Liu, Ning, Hu, Chen‐Yu, Tu, Xian‐Shuang, Li, Xiang, Wang, Xiao‐Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis boron Catalysts Chemical reduction Dihydropyridine Enantiomers heterocycles Heterocyclic compounds Hydroboration Natural products pyridine Pyridines Reagents reduction Substitutes
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