Microbiota modulate sympathetic neurons via a gut–brain circuit

Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content 1 , regulating both physiological intestinal functions such as nutrient absorption and motility 2 , 3 , and brain-wired feeding behaviour 2 . It is therefore plausible that circuits exist to det...

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Veröffentlicht in:	Nature (London) 2020-07, Vol.583 (7816), p.441-446
Hauptverfasser:	Muller, Paul A., Schneeberger, Marc, Matheis, Fanny, Wang, Putianqi, Kerner, Zachary, Ilanges, Anoj, Pellegrino, Kyle, del Mármol, Josefina, Castro, Tiago B. R., Furuichi, Munehiro, Perkins, Matthew, Han, Wenfei, Rao, Arka, Pickard, Amanda J., Cross, Justin R., Honda, Kenya, de Araujo, Ivan, Mucida, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 14 14/32 14/63 38 38/91 631/326/2565/2134 631/378/371 Animal models Animals Antibiotics Bacteria Bile Brain Brain stem Cellular signal transduction Central nervous system Circuits Colonization Consortia Depletion Digestive system Dysbiosis - physiopathology Enteric nervous system Fatty acids Feeding behavior Female Ganglia Ganglia, Sympathetic - cytology Ganglia, Sympathetic - physiology Gastrointestinal Microbiome - physiology Gastrointestinal Motility Gastrointestinal tract Gene expression Germ-Free Life Germfree Glutamatergic transmission Gnotobiotic Humanities and Social Sciences Intestinal microflora Intestine Intestines - innervation Intestines - microbiology Investigations Male Metabolites Mice Mice, Inbred C57BL Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms Models, Animal Motility multidisciplinary Nervous system Nervous system, Sympathetic Neural Pathways - physiology Neuromodulation Neurons Neurons - physiology Nutrient content Observations Ontology Peptides Physiological aspects Physiology Proto-Oncogene Proteins c-fos - metabolism Science Science (multidisciplinary) Sensory neurons Sympathetic ganglia Sympathetic nerves Sympathetic Nervous System - cytology Sympathetic Nervous System - physiology Tracing Transcriptome Vagus nerve
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