Structure Elucidation and Mechanistic Study of a New Dimeric Degradant in Ropinirole Hydrochloride Extended-Release Tablets

Purpose The goal of the study was to elucidate the structure of a new degradant (1,3′-Dimer), generated in the stability testing of ropinirole extended-release tablets, and the formation mechanism of 1,3′-Dimer and its isomer (3,3′-Dimer). Methods The strategy of combining LC-PDA/UV-MS n ( n  = 1, 2...

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