Silver-Catalyzed C–H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes

Silver-Catalyzed C–H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes

The oxidative C–H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reactions are promoted by the combination of cata...

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Veröffentlicht in:Organic letters 2020-07, Vol.22 (14), p.5451-5455
Hauptverfasser: Zhu, Xiao-Lei, Huang, Yangen, Xu, Xiu-Hua, Qing, Feng-Ling
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container_issue 14
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container_title Organic letters
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creator Zhu, Xiao-Lei
Huang, Yangen
Xu, Xiu-Hua
Qing, Feng-Ling
description The oxidative C–H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reactions are promoted by the combination of catalytic AgNO3 and Selectfluor or K2S2O8 to give ArOCF2- and ArSCF2-substituted heteroaromatic compounds in moderate to high yields.
doi_str_mv 10.1021/acs.orglett.0c01826
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title Silver-Catalyzed C–H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes
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