Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016
Objectives To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR). Design Retrospective observational study from January 2009 to November 2016. Setting Large urban referral and emergency facility. Animals One hundre...
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| Veröffentlicht in: | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2020-09, Vol.30 (5), p.558-566 |
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| container_title | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) |
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| creator | Lane, William G. Sinnott‐Stutzman, Virginia B. |
| description | Objectives
To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR).
Design
Retrospective observational study from January 2009 to November 2016.
Setting
Large urban referral and emergency facility.
Animals
One hundred twenty‐one client‐owned cats that received FFP.
Interventions
None.
Measurements and Main Results
Signalment, indication(s), dose, pre‐ and posttransfusion total plasma protein, prothrombin time, activated partial thromboplastin time, as well as possible ATR, primary disease process, and outcome were recorded. Doppler blood pressure was increased posttransfusion (mean pre 99.5 ± 30.8 mm Hg; post 108.5 ± 32.5 mm Hg, P = .027). Cats were significantly less likely to be coagulopathic posttransfusion (P |
| doi_str_mv | 10.1111/vec.12972 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2422003629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2422003629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3252-1eed19aa1ba4726915cd6a8be1facf1ade4d506cb32faed58356f449bf0182513</originalsourceid><addsrcrecordid>eNp1kEtOwzAQhi0EouWx4ALIS1ik9YydtGaHqvKQKiEhYBs5zlgEpU2Jk6Ky4g7ckJNgmsKOWcxY1qdPMz9jJyAGEGq4IjsA1CPcYX1QoyRSSsLu5q0jiQn02IH3L0KA1jHus174UxIl9tnsnpq68kuyTbEiTitTtqYpqgWvHHc1-efQq3da8GVp_Nzw1hMvFhwQuDWNv-AohP76-EQByRHbc6b0dLydh-zxavowuYlmd9e3k8tZZCXGGAFRDtoYyIwaYaIhtnlixhmBM9aByUnlsUhsJtEZyuOxjBOnlM6cgDHGIA_ZWedd1tVrS75J54W3VJZmQVXrU1QYtpIJ6oCed6gNV_qaXLqsi7mp1ymI9Ce8NISXbsIL7OlW22Zzyv_I37QCMOyAt6Kk9f-m9Gk66ZTfTER3sg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2422003629</pqid></control><display><type>article</type><title>Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lane, William G. ; Sinnott‐Stutzman, Virginia B.</creator><creatorcontrib>Lane, William G. ; Sinnott‐Stutzman, Virginia B.</creatorcontrib><description>Objectives
To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR).
Design
Retrospective observational study from January 2009 to November 2016.
Setting
Large urban referral and emergency facility.
Animals
One hundred twenty‐one client‐owned cats that received FFP.
Interventions
None.
Measurements and Main Results
Signalment, indication(s), dose, pre‐ and posttransfusion total plasma protein, prothrombin time, activated partial thromboplastin time, as well as possible ATR, primary disease process, and outcome were recorded. Doppler blood pressure was increased posttransfusion (mean pre 99.5 ± 30.8 mm Hg; post 108.5 ± 32.5 mm Hg, P = .027). Cats were significantly less likely to be coagulopathic posttransfusion (P < 0.001). Most common indications were suspected coagulopathy (n = 105, 83%), hemorrhage (n = 45, 35%), and hypotension (n = 32, 25%). Median dose was 6 mL/kg (interquartile range = 3 mL/kg) and was negatively correlated with body weight (r = –.598, P < 0.001). Possible ATR occurred in 17 of 108 (16%, 95% confidence interval [CI], 10–24%) of transfusions. Increased body temperature was most common in 11 of 108 (10%, 95% CI, 5–18%), followed by tachypnea/dyspnea in 8 of 108 (7%, 95% CI, 3–13%). Common primary disease processes included liver disease (n = 41, 34%), neoplasia (n = 19, 16%), and sepsis (n = 15, 12%). Overall mortality was 54%. Improvement of clotting times was associated with increased odds of survival (odds ratio = 2.4; 95% CI, 1.1–5.3; P = 0.023).
Conclusions
Clinician justifications for FFP transfusions are comparable to that reported in dogs; however, the mL/kg dose is lower. Coagulopathy and blood pressure significantly improve posttransfusion. Possible ATR were as frequent as that reported with feline packed RBCs transfusions and classified as mild.</description><identifier>ISSN: 1479-3261</identifier><identifier>EISSN: 1476-4431</identifier><identifier>DOI: 10.1111/vec.12972</identifier><identifier>PMID: 32643232</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Blood Coagulation Disorders - therapy ; Blood Coagulation Disorders - veterinary ; Blood Transfusion - veterinary ; Cat Diseases - therapy ; Cats ; coagulopathy ; Erythrocyte Transfusion - veterinary ; feline ; Female ; FFP ; Hemorrhage - veterinary ; Male ; Odds Ratio ; Partial Thromboplastin Time - veterinary ; Plasma ; Prothrombin Time - veterinary ; Retrospective Studies ; transfusion ; Treatment Outcome</subject><ispartof>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), 2020-09, Vol.30 (5), p.558-566</ispartof><rights>Veterinary Emergency and Critical Care Society 2020</rights><rights>Veterinary Emergency and Critical Care Society 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3252-1eed19aa1ba4726915cd6a8be1facf1ade4d506cb32faed58356f449bf0182513</citedby><cites>FETCH-LOGICAL-c3252-1eed19aa1ba4726915cd6a8be1facf1ade4d506cb32faed58356f449bf0182513</cites><orcidid>0000-0001-5653-0471 ; 0000-0003-0993-6510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvec.12972$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvec.12972$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32643232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lane, William G.</creatorcontrib><creatorcontrib>Sinnott‐Stutzman, Virginia B.</creatorcontrib><title>Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016</title><title>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</title><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><description>Objectives
To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR).
Design
Retrospective observational study from January 2009 to November 2016.
Setting
Large urban referral and emergency facility.
Animals
One hundred twenty‐one client‐owned cats that received FFP.
Interventions
None.
Measurements and Main Results
Signalment, indication(s), dose, pre‐ and posttransfusion total plasma protein, prothrombin time, activated partial thromboplastin time, as well as possible ATR, primary disease process, and outcome were recorded. Doppler blood pressure was increased posttransfusion (mean pre 99.5 ± 30.8 mm Hg; post 108.5 ± 32.5 mm Hg, P = .027). Cats were significantly less likely to be coagulopathic posttransfusion (P < 0.001). Most common indications were suspected coagulopathy (n = 105, 83%), hemorrhage (n = 45, 35%), and hypotension (n = 32, 25%). Median dose was 6 mL/kg (interquartile range = 3 mL/kg) and was negatively correlated with body weight (r = –.598, P < 0.001). Possible ATR occurred in 17 of 108 (16%, 95% confidence interval [CI], 10–24%) of transfusions. Increased body temperature was most common in 11 of 108 (10%, 95% CI, 5–18%), followed by tachypnea/dyspnea in 8 of 108 (7%, 95% CI, 3–13%). Common primary disease processes included liver disease (n = 41, 34%), neoplasia (n = 19, 16%), and sepsis (n = 15, 12%). Overall mortality was 54%. Improvement of clotting times was associated with increased odds of survival (odds ratio = 2.4; 95% CI, 1.1–5.3; P = 0.023).
Conclusions
Clinician justifications for FFP transfusions are comparable to that reported in dogs; however, the mL/kg dose is lower. Coagulopathy and blood pressure significantly improve posttransfusion. Possible ATR were as frequent as that reported with feline packed RBCs transfusions and classified as mild.</description><subject>Animals</subject><subject>Blood Coagulation Disorders - therapy</subject><subject>Blood Coagulation Disorders - veterinary</subject><subject>Blood Transfusion - veterinary</subject><subject>Cat Diseases - therapy</subject><subject>Cats</subject><subject>coagulopathy</subject><subject>Erythrocyte Transfusion - veterinary</subject><subject>feline</subject><subject>Female</subject><subject>FFP</subject><subject>Hemorrhage - veterinary</subject><subject>Male</subject><subject>Odds Ratio</subject><subject>Partial Thromboplastin Time - veterinary</subject><subject>Plasma</subject><subject>Prothrombin Time - veterinary</subject><subject>Retrospective Studies</subject><subject>transfusion</subject><subject>Treatment Outcome</subject><issn>1479-3261</issn><issn>1476-4431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EouWx4ALIS1ik9YydtGaHqvKQKiEhYBs5zlgEpU2Jk6Ky4g7ckJNgmsKOWcxY1qdPMz9jJyAGEGq4IjsA1CPcYX1QoyRSSsLu5q0jiQn02IH3L0KA1jHus174UxIl9tnsnpq68kuyTbEiTitTtqYpqgWvHHc1-efQq3da8GVp_Nzw1hMvFhwQuDWNv-AohP76-EQByRHbc6b0dLydh-zxavowuYlmd9e3k8tZZCXGGAFRDtoYyIwaYaIhtnlixhmBM9aByUnlsUhsJtEZyuOxjBOnlM6cgDHGIA_ZWedd1tVrS75J54W3VJZmQVXrU1QYtpIJ6oCed6gNV_qaXLqsi7mp1ymI9Ce8NISXbsIL7OlW22Zzyv_I37QCMOyAt6Kk9f-m9Gk66ZTfTER3sg</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Lane, William G.</creator><creator>Sinnott‐Stutzman, Virginia B.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5653-0471</orcidid><orcidid>https://orcid.org/0000-0003-0993-6510</orcidid></search><sort><creationdate>202009</creationdate><title>Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016</title><author>Lane, William G. ; Sinnott‐Stutzman, Virginia B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3252-1eed19aa1ba4726915cd6a8be1facf1ade4d506cb32faed58356f449bf0182513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Blood Coagulation Disorders - therapy</topic><topic>Blood Coagulation Disorders - veterinary</topic><topic>Blood Transfusion - veterinary</topic><topic>Cat Diseases - therapy</topic><topic>Cats</topic><topic>coagulopathy</topic><topic>Erythrocyte Transfusion - veterinary</topic><topic>feline</topic><topic>Female</topic><topic>FFP</topic><topic>Hemorrhage - veterinary</topic><topic>Male</topic><topic>Odds Ratio</topic><topic>Partial Thromboplastin Time - veterinary</topic><topic>Plasma</topic><topic>Prothrombin Time - veterinary</topic><topic>Retrospective Studies</topic><topic>transfusion</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lane, William G.</creatorcontrib><creatorcontrib>Sinnott‐Stutzman, Virginia B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lane, William G.</au><au>Sinnott‐Stutzman, Virginia B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016</atitle><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><date>2020-09</date><risdate>2020</risdate><volume>30</volume><issue>5</issue><spage>558</spage><epage>566</epage><pages>558-566</pages><issn>1479-3261</issn><eissn>1476-4431</eissn><abstract>Objectives
To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR).
Design
Retrospective observational study from January 2009 to November 2016.
Setting
Large urban referral and emergency facility.
Animals
One hundred twenty‐one client‐owned cats that received FFP.
Interventions
None.
Measurements and Main Results
Signalment, indication(s), dose, pre‐ and posttransfusion total plasma protein, prothrombin time, activated partial thromboplastin time, as well as possible ATR, primary disease process, and outcome were recorded. Doppler blood pressure was increased posttransfusion (mean pre 99.5 ± 30.8 mm Hg; post 108.5 ± 32.5 mm Hg, P = .027). Cats were significantly less likely to be coagulopathic posttransfusion (P < 0.001). Most common indications were suspected coagulopathy (n = 105, 83%), hemorrhage (n = 45, 35%), and hypotension (n = 32, 25%). Median dose was 6 mL/kg (interquartile range = 3 mL/kg) and was negatively correlated with body weight (r = –.598, P < 0.001). Possible ATR occurred in 17 of 108 (16%, 95% confidence interval [CI], 10–24%) of transfusions. Increased body temperature was most common in 11 of 108 (10%, 95% CI, 5–18%), followed by tachypnea/dyspnea in 8 of 108 (7%, 95% CI, 3–13%). Common primary disease processes included liver disease (n = 41, 34%), neoplasia (n = 19, 16%), and sepsis (n = 15, 12%). Overall mortality was 54%. Improvement of clotting times was associated with increased odds of survival (odds ratio = 2.4; 95% CI, 1.1–5.3; P = 0.023).
Conclusions
Clinician justifications for FFP transfusions are comparable to that reported in dogs; however, the mL/kg dose is lower. Coagulopathy and blood pressure significantly improve posttransfusion. Possible ATR were as frequent as that reported with feline packed RBCs transfusions and classified as mild.</abstract><cop>United States</cop><pmid>32643232</pmid><doi>10.1111/vec.12972</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5653-0471</orcidid><orcidid>https://orcid.org/0000-0003-0993-6510</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Blood Coagulation Disorders - therapy Blood Coagulation Disorders - veterinary Blood Transfusion - veterinary Cat Diseases - therapy Cats coagulopathy Erythrocyte Transfusion - veterinary feline Female FFP Hemorrhage - veterinary Male Odds Ratio Partial Thromboplastin Time - veterinary Plasma Prothrombin Time - veterinary Retrospective Studies transfusion Treatment Outcome |
| title | Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016 |
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