Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases
Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The t...
Gespeichert in:
Veröffentlicht in: | Australasian journal of dermatology 2021-02, Vol.62 (1), p.e83-e85 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e85 |
---|---|
container_issue | 1 |
container_start_page | e83 |
container_title | Australasian journal of dermatology |
container_volume | 62 |
creator | Akdogan, Neslihan Ersoy‐Evans, Sibel |
description | Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The treatment outcome was retrospectively evaluated using the Severity of Alopecia Tool (SALT), and at the end of 6 months, patients with a ≥50% decrease in the SALT score were considered as strong responders, a 5%‐50% decrease as intermediate responders and a |
doi_str_mv | 10.1111/ajd.13391 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2421459344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2421459344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-f47dd7b49aefcf207ca8ab1df35b5dd0c44b0fe3b35b128ad581a366db29251e3</originalsourceid><addsrcrecordid>eNp1kE9LwzAYh4Mobk4PfgEpeNFDXdIkXettzD9zDARx55Imb7CjbWbS6vrtzez0IJjLS-Dh4ceD0DnBN8S_sVirG0JpSg7QkDCGQ5zG-BANMcYsTGiCB-jEuTXGhBLOj9GARjFNKI-GaDHvlDXbTr6Vxpr3tqghaCyIpoK6CbSxwbQ0G5CFCFZ18QHWibJwt8ELbIxtAqMDV2wDKRy4U3SkRengbH9HaPVw_zqbh8vnx6fZdBlKyikJNZsoNclZKkBLHeGJFInIidKU51wpLBnLsQaa-z-JEqF4QgSNY5VHacQJ0BG66r2b3WBwTVYVTkJZihpM67KIRYTxlDLm0cs_6Nq0tvbrPJWkxA_yJUbouqekNc5Z0NnGFpWwXUZwtguc-cDZd2DPXuyNbV6B-iV_inpg3AOfRQnd_6ZsurjrlV92xISQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489135326</pqid></control><display><type>article</type><title>Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Akdogan, Neslihan ; Ersoy‐Evans, Sibel</creator><creatorcontrib>Akdogan, Neslihan ; Ersoy‐Evans, Sibel</creatorcontrib><description>Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The treatment outcome was retrospectively evaluated using the Severity of Alopecia Tool (SALT), and at the end of 6 months, patients with a ≥50% decrease in the SALT score were considered as strong responders, a 5%‐50% decrease as intermediate responders and a <5% decrease as non‐responders. The present findings indicate that hydroxychloroquine is not an effective treatment since in 5 of the 6 patients it was discontinued at the end of 6 months due to lack of hair regrowth, whereas only a 6‐year‐old boy responded with a SALT score change of 8% after the 12th month.</description><identifier>ISSN: 0004-8380</identifier><identifier>EISSN: 1440-0960</identifier><identifier>DOI: 10.1111/ajd.13391</identifier><identifier>PMID: 32638352</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Alopecia ; alopecia universalis ; Baldness ; Hydroxychloroquine ; treatment</subject><ispartof>Australasian journal of dermatology, 2021-02, Vol.62 (1), p.e83-e85</ispartof><rights>2020 The Australasian College of Dermatologists</rights><rights>2020 The Australasian College of Dermatologists.</rights><rights>Copyright © 2021 The Australasian College of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-f47dd7b49aefcf207ca8ab1df35b5dd0c44b0fe3b35b128ad581a366db29251e3</citedby><cites>FETCH-LOGICAL-c3531-f47dd7b49aefcf207ca8ab1df35b5dd0c44b0fe3b35b128ad581a366db29251e3</cites><orcidid>0000-0002-1137-5399 ; 0000-0002-5040-2476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajd.13391$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajd.13391$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32638352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akdogan, Neslihan</creatorcontrib><creatorcontrib>Ersoy‐Evans, Sibel</creatorcontrib><title>Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases</title><title>Australasian journal of dermatology</title><addtitle>Australas J Dermatol</addtitle><description>Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The treatment outcome was retrospectively evaluated using the Severity of Alopecia Tool (SALT), and at the end of 6 months, patients with a ≥50% decrease in the SALT score were considered as strong responders, a 5%‐50% decrease as intermediate responders and a <5% decrease as non‐responders. The present findings indicate that hydroxychloroquine is not an effective treatment since in 5 of the 6 patients it was discontinued at the end of 6 months due to lack of hair regrowth, whereas only a 6‐year‐old boy responded with a SALT score change of 8% after the 12th month.</description><subject>Alopecia</subject><subject>alopecia universalis</subject><subject>Baldness</subject><subject>Hydroxychloroquine</subject><subject>treatment</subject><issn>0004-8380</issn><issn>1440-0960</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LwzAYh4Mobk4PfgEpeNFDXdIkXettzD9zDARx55Imb7CjbWbS6vrtzez0IJjLS-Dh4ceD0DnBN8S_sVirG0JpSg7QkDCGQ5zG-BANMcYsTGiCB-jEuTXGhBLOj9GARjFNKI-GaDHvlDXbTr6Vxpr3tqghaCyIpoK6CbSxwbQ0G5CFCFZ18QHWibJwt8ELbIxtAqMDV2wDKRy4U3SkRengbH9HaPVw_zqbh8vnx6fZdBlKyikJNZsoNclZKkBLHeGJFInIidKU51wpLBnLsQaa-z-JEqF4QgSNY5VHacQJ0BG66r2b3WBwTVYVTkJZihpM67KIRYTxlDLm0cs_6Nq0tvbrPJWkxA_yJUbouqekNc5Z0NnGFpWwXUZwtguc-cDZd2DPXuyNbV6B-iV_inpg3AOfRQnd_6ZsurjrlV92xISQ</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Akdogan, Neslihan</creator><creator>Ersoy‐Evans, Sibel</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1137-5399</orcidid><orcidid>https://orcid.org/0000-0002-5040-2476</orcidid></search><sort><creationdate>202102</creationdate><title>Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases</title><author>Akdogan, Neslihan ; Ersoy‐Evans, Sibel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-f47dd7b49aefcf207ca8ab1df35b5dd0c44b0fe3b35b128ad581a366db29251e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alopecia</topic><topic>alopecia universalis</topic><topic>Baldness</topic><topic>Hydroxychloroquine</topic><topic>treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akdogan, Neslihan</creatorcontrib><creatorcontrib>Ersoy‐Evans, Sibel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Australasian journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akdogan, Neslihan</au><au>Ersoy‐Evans, Sibel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases</atitle><jtitle>Australasian journal of dermatology</jtitle><addtitle>Australas J Dermatol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>62</volume><issue>1</issue><spage>e83</spage><epage>e85</epage><pages>e83-e85</pages><issn>0004-8380</issn><eissn>1440-0960</eissn><abstract>Recent reports indicate that hydroxychloroquine is a potential new treatment option for alopecia universalis; thus, we aimed to report on the safety and efficacy of hydroxychloroquine in 6 patients with refractory alopecia universalis that were treated with 400 mg/d continuously for ≥6 months. The treatment outcome was retrospectively evaluated using the Severity of Alopecia Tool (SALT), and at the end of 6 months, patients with a ≥50% decrease in the SALT score were considered as strong responders, a 5%‐50% decrease as intermediate responders and a <5% decrease as non‐responders. The present findings indicate that hydroxychloroquine is not an effective treatment since in 5 of the 6 patients it was discontinued at the end of 6 months due to lack of hair regrowth, whereas only a 6‐year‐old boy responded with a SALT score change of 8% after the 12th month.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32638352</pmid><doi>10.1111/ajd.13391</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-1137-5399</orcidid><orcidid>https://orcid.org/0000-0002-5040-2476</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0004-8380 |
ispartof | Australasian journal of dermatology, 2021-02, Vol.62 (1), p.e83-e85 |
issn | 0004-8380 1440-0960 |
language | eng |
recordid | cdi_proquest_miscellaneous_2421459344 |
source | Wiley Online Library Journals Frontfile Complete |
subjects | Alopecia alopecia universalis Baldness Hydroxychloroquine treatment |
title | Hydroxychloroquine treatment for Alopecia Universalis: Report of six cases |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T11%3A31%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hydroxychloroquine%20treatment%20for%20Alopecia%20Universalis:%20Report%20of%20six%20cases&rft.jtitle=Australasian%20journal%20of%20dermatology&rft.au=Akdogan,%20Neslihan&rft.date=2021-02&rft.volume=62&rft.issue=1&rft.spage=e83&rft.epage=e85&rft.pages=e83-e85&rft.issn=0004-8380&rft.eissn=1440-0960&rft_id=info:doi/10.1111/ajd.13391&rft_dat=%3Cproquest_cross%3E2421459344%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489135326&rft_id=info:pmid/32638352&rfr_iscdi=true |