Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K+ channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones

[Display omitted] •Synthesis of a new series of 3-aryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines.•Nitro-derivatives exhibited a significant anticancer activity against five human cancer cell.•Moreover, the cytotoxic profile of the newly synthesized compounds was checked.•The most activ...

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