N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations

[Display omitted] •New diaryl ether-containing amides.•A new inhibitor of mitochondrial complex III.•Good amide – Π stacking interactions. Mitochondrial complex III is one of the most promising targets for a number of pharmaceuticals and fungicides. Due to the wide-spreaduse of complex III-inhibitin...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-08, Vol.30 (16), p.127302-127302, Article 127302
Hauptverfasser:	Cheng, Hua, Yang, Lu, Liu, Hong-Fu, Zhang, Rui, Chen, Cheng, Wu, Yuan, Jiang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amide Biological evaluation Computational simulation Diaryl ether Inhibitor Mitochondrial complex III
Online-Zugang:	Volltext
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