PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10‐mediated anti‐inflammatory response

Inflammatory responses are pivotal incidences in hepatic metabolic derangements. However, the underlying mechanism remains elusive. The present study aimed to evaluate the role of peroxisome proliferator‐activated receptor‐gamma, coactivator 1 alpha (PGC1α) in IL10‐mediated anti‐inflammatory respons...

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Veröffentlicht in:	The FASEB journal 2020-08, Vol.34 (8), p.10751-10761
Hauptverfasser:	Wan, Xingyong, Zhu, Xudong, Wang, Hu, Feng, Ye, Zhou, Weihua, Liu, Peihao, Shen, Weiyan, Zhang, Lingling, Liu, Leiming, Li, Tangliang, Diao, Daojun, Yang, Fan, Zhao, Qi, Chen, Li, Ren, Jian, Yan, Sheng, Li, Jing, Yu, Chaohui, Ju, Zhenyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - metabolism Antibodies, Neutralizing - metabolism Fatty Liver - metabolism Gene Expression - physiology hepatic steatosis Hepatocytes - metabolism IL‐10 inflammation Inflammation - metabolism insulin resistance Insulin Resistance - physiology Interleukin-10 - metabolism Lipid Metabolism - physiology Liver - metabolism Male Mice Mitochondria - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC1α Protective Agents - metabolism
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