Control of the Rate of Fibroblast Migration and Spreading by Defensin Oligopeptide Fragment
The elaboration of modes for directed regulation of cell transition from the nonmotile fixed status to the motile state, and vice versa, is referred to the most important problems of practical medicine. Nowadays, the creation of biopreparations on the basis of naturally occurring compounds for the m...
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| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2020-05, Vol.492 (1), p.108-111 |
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| container_title | Doklady. Biochemistry and biophysics |
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| creator | Ivanova, V. P. Krivchenko, A. I. |
| description | The elaboration of modes for directed regulation of cell transition from the nonmotile fixed status to the motile state, and vice versa, is referred to the most important problems of practical medicine. Nowadays, the creation of biopreparations on the basis of naturally occurring compounds for the minimization or elimination of negative consequences at the cell malignization is an actual problem. The effect of synthetic peptide GERA (a fragment of antimicrobial polypeptides defensins) on the spreading and migration of embryonic fibroblasts was studied. The peptide was found to increase the number of spread cells in cell population compared to the control cells. In addition, the GERA peptide stimulates the directed migration of fibroblasts to wounded zone of cell monolayer (i.e., substrate areas free from cells). The most probable cell targets in spreading and migrating fibroblasts under peptide action are the structural and regulatory components of focal adhesions. |
| doi_str_mv | 10.1134/S1607672920030011 |
| format | Article |
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P.</creatorcontrib><creatorcontrib>Krivchenko, A. I.</creatorcontrib><title>Control of the Rate of Fibroblast Migration and Spreading by Defensin Oligopeptide Fragment</title><title>Doklady. Biochemistry and biophysics</title><addtitle>Dokl Biochem Biophys</addtitle><addtitle>Dokl Biochem Biophys</addtitle><description>The elaboration of modes for directed regulation of cell transition from the nonmotile fixed status to the motile state, and vice versa, is referred to the most important problems of practical medicine. Nowadays, the creation of biopreparations on the basis of naturally occurring compounds for the minimization or elimination of negative consequences at the cell malignization is an actual problem. The effect of synthetic peptide GERA (a fragment of antimicrobial polypeptides defensins) on the spreading and migration of embryonic fibroblasts was studied. The peptide was found to increase the number of spread cells in cell population compared to the control cells. In addition, the GERA peptide stimulates the directed migration of fibroblasts to wounded zone of cell monolayer (i.e., substrate areas free from cells). 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| ispartof | Doklady. Biochemistry and biophysics, 2020-05, Vol.492 (1), p.108-111 |
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| subjects | Animals Anti-Infective Agents - pharmacology Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Cell Adhesion Cell Movement Cells, Cultured Defensins Defensins - pharmacology Embryo fibroblasts Fibroblasts Fibroblasts - drug effects Fibroblasts - physiology Life Sciences Mice Molecular Biology Oligopeptides - pharmacology Peptides Signal Transduction |
| title | Control of the Rate of Fibroblast Migration and Spreading by Defensin Oligopeptide Fragment |
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