Dual pH/ROS‐Responsive Nanoplatform with Deep Tumor Penetration and Self‐Amplified Drug Release for Enhancing Tumor Chemotherapeutic Efficacy

Poor deep tumor penetration and incomplete intracellular drug release remain challenges for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA‐NPs) is developed that can achieve prolonged blood circulation, deep tumor penetration, active‐targeting of cancer cells,...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-08, Vol.16 (32), p.e2002188-n/a
Hauptverfasser:	Li, Yongfei, Chen, Mie, Yao, Bowen, Lu, Xun, Song, Boyang, Vasilatos, Shauna N., Zhang, Xiang, Ren, Xiaomei, Yao, Chang, Bian, Weihe, Sun, Lizhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Blood circulation Cancer deep tumor penetration Drug delivery systems Endosomes Imidazole In vivo methods and tests lysosome escape Micelles Nanotechnology Penetration pH/ROS‐cascade responsive proton sponge effect Selectivity self‐amplified drug release
Online-Zugang:	Volltext
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