Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes

•A thalidomide derivative was assessed for its anti-inflammatory activity.•The derivative suppressed cytokine expression to a greater degree than thalidomide.•The derivative penetrated skin due to its feasible lipophilicity and small size.•This compound regulated inflammation via inhibition of MAPKs...

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Veröffentlicht in:	Journal of dermatological science 2020-08, Vol.99 (2), p.90-99
Hauptverfasser:	Tang, Kai-Wei, Lin, Zih-Chan, Wang, Pei-Wen, Alalaiwe, Ahmed, Tseng, Chih-Hua, Fang, Jia-You
Format:	Artikel
Sprache:	eng
Schlagworte:	2-[1-(3-chlorobenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione Inflammation Psoriasis Skin Skin targeting Thalidomide
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