Curcumin inhibits the formation of atherosclerosis in ApoE−/− mice by suppressing cytomegalovirus activity in endothelial cells
Curcumin (Cur) is a hydrophobic polyphenol compound derived from the rhizome of the herb Curcuma longa. Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur ex...
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| Veröffentlicht in: | Life sciences (1973) 2020-09, Vol.257, p.117658-117658, Article 117658 |
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| container_title | Life sciences (1973) |
| container_volume | 257 |
| creator | Lv, Ya-li Jia, Yangjie Wan, Zirui An, Zhuo-ling Yang, Song Han, Fei-fei Gong, Li-li Xuan, Ling-ling Ren, Lu-lu Zhang, Wen Liu, He Liu, Li-hong |
| description | Curcumin (Cur) is a hydrophobic polyphenol compound derived from the rhizome of the herb Curcuma longa. Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur exhibited an outstanding anti-HCMV effect. However, anti-AS effects of Cur remain unclear when HCMV infected endothelial cells.
This study will investigate the anti-AS activities and mechanism of Cur,when HCMV infected in vivo and in vitro.
Cur (0.5, 1, and 2 μM) was used to explore the anti-AS activities and mechanism after HCMV infected endothelial cells in vitro. ApoE−/− mice were fed a high fat and cholesterol diet (HD) and given 4000,000 copies/mouse MCMV infection by intraperitoneal and treated with ganciclovir (5 mg/kg/d), Cur (25, 15 mg/kg/d) for 10 weeks in vivo.
As our results showed that Cur inhibited CMV replication and proliferation, reduced the intracellular ROS overproduction, decreased the release of inflammatory cytokines, down-regulated the level of HMGB1-TLRS-NF-κB signaling pathway-related proteins in vitro experiments. Cur reduced the serum levels of LDL-C, TC and TG, significantly decreased the formation of atherosclerotic plaque in the aorta, reduced the lipid deposition in liver and inflammatory damage in heart, lung and kidney in vivo experiments.
This study showed that Cur prevent AS progression by inhibiting CMV activity and CMV-induced HMGB1-TLRS-NF-κB signaling pathway.
[Display omitted] |
| doi_str_mv | 10.1016/j.lfs.2020.117658 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2420150389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320520304069</els_id><sourcerecordid>2420150389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-765f9775a774a5ed7c56b34249e07d800e8f0496e52b271c1c42fb321aeda1eb3</originalsourceid><addsrcrecordid>eNqFkb-O1DAQxi0EEsvBA9BZoqHJ3tix41hUp9XxRzqJBmrLcSZ3XiVxsJ2Vtqa5mkfkSXC0VBRH4bE8-n2fPPMR8pbBngFrro_7cUh7Dry8mWpk-4zsWKt0BU3NnpMdABdVzUG-JK9SOgKAlKrekZ-HNbp18jP184PvfE40PyAdQpxs9mGmYaC2dGJIbtyqT4WkN0u4_f3467ocOnmHtDvTtC5LxJT8fE_dOYcJ7-0YTj6uiVqX_cnn86bFuQ_FcfR2pA7HMb0mLwY7Jnzz974i3z_efjt8ru6-fvpyuLmrXK1ZrspUg1ZKWqWEldgrJ5uuFlxoBNW3ANgOIHSDkndcMcec4ENXc2axtwy7-oq8v_guMfxYMWUz-bT9wM4Y1mS4FCBaDVr9HxUcmIS61QV99w96DGucyyDFEKTiUovNkF0oV3aYIg5miX6y8WwYmC1BczQlQbMlaC4JFs2HiwbLUk4eo0nO4-yw9xFdNn3wT6j_APc9pts</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2505725947</pqid></control><display><type>article</type><title>Curcumin inhibits the formation of atherosclerosis in ApoE−/− mice by suppressing cytomegalovirus activity in endothelial cells</title><source>Elsevier ScienceDirect Journals</source><creator>Lv, Ya-li ; Jia, Yangjie ; Wan, Zirui ; An, Zhuo-ling ; Yang, Song ; Han, Fei-fei ; Gong, Li-li ; Xuan, Ling-ling ; Ren, Lu-lu ; Zhang, Wen ; Liu, He ; Liu, Li-hong</creator><creatorcontrib>Lv, Ya-li ; Jia, Yangjie ; Wan, Zirui ; An, Zhuo-ling ; Yang, Song ; Han, Fei-fei ; Gong, Li-li ; Xuan, Ling-ling ; Ren, Lu-lu ; Zhang, Wen ; Liu, He ; Liu, Li-hong</creatorcontrib><description>Curcumin (Cur) is a hydrophobic polyphenol compound derived from the rhizome of the herb Curcuma longa. Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur exhibited an outstanding anti-HCMV effect. However, anti-AS effects of Cur remain unclear when HCMV infected endothelial cells.
This study will investigate the anti-AS activities and mechanism of Cur,when HCMV infected in vivo and in vitro.
Cur (0.5, 1, and 2 μM) was used to explore the anti-AS activities and mechanism after HCMV infected endothelial cells in vitro. ApoE−/− mice were fed a high fat and cholesterol diet (HD) and given 4000,000 copies/mouse MCMV infection by intraperitoneal and treated with ganciclovir (5 mg/kg/d), Cur (25, 15 mg/kg/d) for 10 weeks in vivo.
As our results showed that Cur inhibited CMV replication and proliferation, reduced the intracellular ROS overproduction, decreased the release of inflammatory cytokines, down-regulated the level of HMGB1-TLRS-NF-κB signaling pathway-related proteins in vitro experiments. Cur reduced the serum levels of LDL-C, TC and TG, significantly decreased the formation of atherosclerotic plaque in the aorta, reduced the lipid deposition in liver and inflammatory damage in heart, lung and kidney in vivo experiments.
This study showed that Cur prevent AS progression by inhibiting CMV activity and CMV-induced HMGB1-TLRS-NF-κB signaling pathway.
[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2020.117658</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Aorta ; Apolipoprotein E ; Aquatic plants ; Arteriosclerosis ; Atherosclerosis ; blood serum ; Cholesterol ; Curcuma longa ; Curcumin ; Cytokines ; Cytomegalovirus ; diet ; Endothelial cells ; Ganciclovir ; Health risks ; heart ; High cholesterol diet ; High fat diet ; HMGB1 protein ; Human betaherpesvirus 5 ; Hydrophobicity ; In vitro methods and tests ; In vivo methods and tests ; Infection ; Infections ; Inflammation ; Kidneys ; Lipids ; liver ; lungs ; mice ; NF-κB protein ; polyphenols ; Rhizomes ; Risk analysis ; Risk factors ; Serum levels ; Signal transduction ; Signaling</subject><ispartof>Life sciences (1973), 2020-09, Vol.257, p.117658-117658, Article 117658</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright Elsevier BV Sep 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-765f9775a774a5ed7c56b34249e07d800e8f0496e52b271c1c42fb321aeda1eb3</citedby><cites>FETCH-LOGICAL-c391t-765f9775a774a5ed7c56b34249e07d800e8f0496e52b271c1c42fb321aeda1eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2020.117658$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Lv, Ya-li</creatorcontrib><creatorcontrib>Jia, Yangjie</creatorcontrib><creatorcontrib>Wan, Zirui</creatorcontrib><creatorcontrib>An, Zhuo-ling</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><creatorcontrib>Han, Fei-fei</creatorcontrib><creatorcontrib>Gong, Li-li</creatorcontrib><creatorcontrib>Xuan, Ling-ling</creatorcontrib><creatorcontrib>Ren, Lu-lu</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Liu, He</creatorcontrib><creatorcontrib>Liu, Li-hong</creatorcontrib><title>Curcumin inhibits the formation of atherosclerosis in ApoE−/− mice by suppressing cytomegalovirus activity in endothelial cells</title><title>Life sciences (1973)</title><description>Curcumin (Cur) is a hydrophobic polyphenol compound derived from the rhizome of the herb Curcuma longa. Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur exhibited an outstanding anti-HCMV effect. However, anti-AS effects of Cur remain unclear when HCMV infected endothelial cells.
This study will investigate the anti-AS activities and mechanism of Cur,when HCMV infected in vivo and in vitro.
Cur (0.5, 1, and 2 μM) was used to explore the anti-AS activities and mechanism after HCMV infected endothelial cells in vitro. ApoE−/− mice were fed a high fat and cholesterol diet (HD) and given 4000,000 copies/mouse MCMV infection by intraperitoneal and treated with ganciclovir (5 mg/kg/d), Cur (25, 15 mg/kg/d) for 10 weeks in vivo.
As our results showed that Cur inhibited CMV replication and proliferation, reduced the intracellular ROS overproduction, decreased the release of inflammatory cytokines, down-regulated the level of HMGB1-TLRS-NF-κB signaling pathway-related proteins in vitro experiments. Cur reduced the serum levels of LDL-C, TC and TG, significantly decreased the formation of atherosclerotic plaque in the aorta, reduced the lipid deposition in liver and inflammatory damage in heart, lung and kidney in vivo experiments.
This study showed that Cur prevent AS progression by inhibiting CMV activity and CMV-induced HMGB1-TLRS-NF-κB signaling pathway.
[Display omitted]</description><subject>Aorta</subject><subject>Apolipoprotein E</subject><subject>Aquatic plants</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>blood serum</subject><subject>Cholesterol</subject><subject>Curcuma longa</subject><subject>Curcumin</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>diet</subject><subject>Endothelial cells</subject><subject>Ganciclovir</subject><subject>Health risks</subject><subject>heart</subject><subject>High cholesterol diet</subject><subject>High fat diet</subject><subject>HMGB1 protein</subject><subject>Human betaherpesvirus 5</subject><subject>Hydrophobicity</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Infection</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Kidneys</subject><subject>Lipids</subject><subject>liver</subject><subject>lungs</subject><subject>mice</subject><subject>NF-κB protein</subject><subject>polyphenols</subject><subject>Rhizomes</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Serum levels</subject><subject>Signal transduction</subject><subject>Signaling</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkb-O1DAQxi0EEsvBA9BZoqHJ3tix41hUp9XxRzqJBmrLcSZ3XiVxsJ2Vtqa5mkfkSXC0VBRH4bE8-n2fPPMR8pbBngFrro_7cUh7Dry8mWpk-4zsWKt0BU3NnpMdABdVzUG-JK9SOgKAlKrekZ-HNbp18jP184PvfE40PyAdQpxs9mGmYaC2dGJIbtyqT4WkN0u4_f3467ocOnmHtDvTtC5LxJT8fE_dOYcJ7-0YTj6uiVqX_cnn86bFuQ_FcfR2pA7HMb0mLwY7Jnzz974i3z_efjt8ru6-fvpyuLmrXK1ZrspUg1ZKWqWEldgrJ5uuFlxoBNW3ANgOIHSDkndcMcec4ENXc2axtwy7-oq8v_guMfxYMWUz-bT9wM4Y1mS4FCBaDVr9HxUcmIS61QV99w96DGucyyDFEKTiUovNkF0oV3aYIg5miX6y8WwYmC1BczQlQbMlaC4JFs2HiwbLUk4eo0nO4-yw9xFdNn3wT6j_APc9pts</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Lv, Ya-li</creator><creator>Jia, Yangjie</creator><creator>Wan, Zirui</creator><creator>An, Zhuo-ling</creator><creator>Yang, Song</creator><creator>Han, Fei-fei</creator><creator>Gong, Li-li</creator><creator>Xuan, Ling-ling</creator><creator>Ren, Lu-lu</creator><creator>Zhang, Wen</creator><creator>Liu, He</creator><creator>Liu, Li-hong</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20200915</creationdate><title>Curcumin inhibits the formation of atherosclerosis in ApoE−/− mice by suppressing cytomegalovirus activity in endothelial cells</title><author>Lv, Ya-li ; 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Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur exhibited an outstanding anti-HCMV effect. However, anti-AS effects of Cur remain unclear when HCMV infected endothelial cells.
This study will investigate the anti-AS activities and mechanism of Cur,when HCMV infected in vivo and in vitro.
Cur (0.5, 1, and 2 μM) was used to explore the anti-AS activities and mechanism after HCMV infected endothelial cells in vitro. ApoE−/− mice were fed a high fat and cholesterol diet (HD) and given 4000,000 copies/mouse MCMV infection by intraperitoneal and treated with ganciclovir (5 mg/kg/d), Cur (25, 15 mg/kg/d) for 10 weeks in vivo.
As our results showed that Cur inhibited CMV replication and proliferation, reduced the intracellular ROS overproduction, decreased the release of inflammatory cytokines, down-regulated the level of HMGB1-TLRS-NF-κB signaling pathway-related proteins in vitro experiments. Cur reduced the serum levels of LDL-C, TC and TG, significantly decreased the formation of atherosclerotic plaque in the aorta, reduced the lipid deposition in liver and inflammatory damage in heart, lung and kidney in vivo experiments.
This study showed that Cur prevent AS progression by inhibiting CMV activity and CMV-induced HMGB1-TLRS-NF-κB signaling pathway.
[Display omitted]</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.lfs.2020.117658</doi><tpages>1</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Aorta Apolipoprotein E Aquatic plants Arteriosclerosis Atherosclerosis blood serum Cholesterol Curcuma longa Curcumin Cytokines Cytomegalovirus diet Endothelial cells Ganciclovir Health risks heart High cholesterol diet High fat diet HMGB1 protein Human betaherpesvirus 5 Hydrophobicity In vitro methods and tests In vivo methods and tests Infection Infections Inflammation Kidneys Lipids liver lungs mice NF-κB protein polyphenols Rhizomes Risk analysis Risk factors Serum levels Signal transduction Signaling |
| title | Curcumin inhibits the formation of atherosclerosis in ApoE−/− mice by suppressing cytomegalovirus activity in endothelial cells |
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