A therapeutic HPV16 E7 vaccine in combination with active anti-FGF-2 immunization synergistically elicits robust antitumor immunity in mice

FGF-2 accumulates in many tumor tissues and is closely related to the development of tumor angiogenesis and the immunosuppressive microenvironment. This study aimed to investigate whether active immunization against FGF-2 could modify antitumor immunity and enhance the efficacy of an HPV16 E7-specif...

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Veröffentlicht in:	Nanomedicine 2020-10, Vol.29, p.102254-102254, Article 102254
Hauptverfasser:	Xie, Hanghang, Shu, Congyan, Bai, Hongmei, Sun, Pengyan, Liu, Hongxian, Qi, Jialong, Li, Sijin, Ye, Chao, Gao, Fulan, Yuan, Mingcui, Chen, Yongjun, Pan, Manchang, Yang, Xu, Ma, Yanbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-cytokine active immunization Fibroblast growth factor-2 (FGF-2) Human papillomavirus (HPV) Therapeutic vaccine Virus-like particle (VLP)
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