Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway

Bergenin, a type of polyphenol compound, exhibits antiulcerogenic, anti-inflammatory, antitussive, and burn wound-healing properties. However, its therapeutic effect on tumor necrosis factor α (TNF-α)-induced proinflammatory responses in the airway and potential mechanisms of actions are still uncle...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2020-06, Vol.62, p.101921-101921, Article 101921
Hauptverfasser:	Chen, Min, Chen, Cuifen, Gao, Yun, Li, Dongming, Huang, Dan, Chen, Ziyu, Zhao, Xuanna, Huang, Qiu, Wu, Dong, Lai, Tianwen, Su, Guomei, Wu, Bin, Zhou, Beixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory Anti-Inflammatory Agents - pharmacology Asthma Benzopyrans - pharmacology Bergenin Cytokines - drug effects Dexamethasone - pharmacology Epithelial Cells Humans Inflammation - drug therapy Naphthols - pharmacology NF-kappa B - drug effects NF-kappa B - metabolism NF-κB Phenylpropionates - pharmacology Signal Transduction - drug effects Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - metabolism Sirtuin-1 Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
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