Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1
Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal...
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| Veröffentlicht in: | Future oncology (London, England) England), 2020-09, Vol.16 (27), p.2075-2087 |
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| container_title | Future oncology (London, England) |
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| creator | Narumiya, Kosuke Bollschweiler, Elfriede Hölscher, Arnulf H Yamamoto, Masakazu Drebber, Uta Alakus, Hakan Metzger, Ralf Warnecke-Eberz, Ute |
| description | Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients’ groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response. |
| doi_str_mv | 10.2217/fon-2020-0489 |
| format | Article |
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Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients’ groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2020-0489</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>Abdomen ; Cancer therapies ; Chemotherapy ; Drug dosages ; Esophageal cancer ; Lymphatic system ; Medical prognosis ; Metastasis ; Ostomy ; Radiation therapy ; Squamous cell carcinoma ; Surgery</subject><ispartof>Future oncology (London, England), 2020-09, Vol.16 (27), p.2075-2087</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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| subjects | Abdomen Cancer therapies Chemotherapy Drug dosages Esophageal cancer Lymphatic system Medical prognosis Metastasis Ostomy Radiation therapy Squamous cell carcinoma Surgery |
| title | Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1 |
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