Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole
Purpose To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH). Methods In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who...
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| creator | Qi, Biying Yu, Yanping You, Qisheng Wang, Zengyi Wang, Jing Liu, Lingzi Liu, Wu |
| description | Purpose
To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH).
Methods
In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed.
Results
The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (
P
|
| doi_str_mv | 10.1007/s00417-020-04814-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2419423825</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2668572692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-bb1593d8781386ccfa8bbfc45cac9ba103634e8e686cb370821d48b5aa80c1dd3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMoWKt_wFXAjZtonjOZpZT6AMGNQnchk8m0U9JJTSaF_nszjiC4cHUv93zncDkAXBN8RzAu7yPGnJQIU4wwl4QjcQJmhDOBSkxXp2CGS0qQZHR1Di5i3OLMM0FmYL08eJeGzvdQ9w08dDFpB30ajN_ZCH077jbA1h-sdzpAl4ztzRHqdjzHFNY2HLOcFZ132DWd3-th0xm40yaNlo139hKctdpFe_Uz5-Djcfm-eEavb08vi4dXZJigA6prIirWyFISJgtjWi3rujVcGG2qWhPMCsattEUWa1ZiSUnDZS20ltiQpmFzcDvl7oP_TDYOatdFY53TvfUpKspJxSmTVGT05g-69Sn0-TtFi0KKkhYVzRSdKBN8jMG2ah-6nQ5HRbAau1dT9yp3r767V2M0m0wxw31u6Df6H9cXhdCInw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2668572692</pqid></control><display><type>article</type><title>Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole</title><source>SpringerLink Journals - AutoHoldings</source><creator>Qi, Biying ; Yu, Yanping ; You, Qisheng ; Wang, Zengyi ; Wang, Jing ; Liu, Lingzi ; Liu, Wu</creator><creatorcontrib>Qi, Biying ; Yu, Yanping ; You, Qisheng ; Wang, Zengyi ; Wang, Jing ; Liu, Lingzi ; Liu, Wu</creatorcontrib><description>Purpose
To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH).
Methods
In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed.
Results
The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (
P
< 0.001) and 34.2% (25/73) at 10 months (
P
< 0.001). The incidence was 26.1% (40/153) and 22.0% (9/41) at 4 and 10 months, respectively. OFL appeared at 1 month while disappeared at 4 or 10 months in 8 eyes (50.0%). The presence of OFL at 1 month was negatively associated with IMH diameter (Nagelkerke
R
2
= 0.06;
P
= 0.02). Eyes with OFL at 4 months had better VA at their 4-month visit than eyes without OFL (
P
= 0.02). Eyes with early-developed OFLs had better VA at 10 months than those with later-developed ones (
P
= 0.02). Width of OFL was not associated with postoperative VA at any point.
Conclusions
OFL is not rare in eyes with large IMH after surgery. It can occur gradually and remain during the 10-month follow-up. The presence of OFL appears to have no negative impact on the postoperative VA and it may represent the remodeling of foveal photoreceptors.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-020-04814-5</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acuity ; Eye ; Hospitals ; Macular Holes ; Medicine ; Medicine & Public Health ; Ophthalmology ; Photoreceptors ; Regression analysis ; Retinal Disorders ; Statistical analysis ; Surgery ; Tomography</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2020-10, Vol.258 (10), p.2117-2124</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-bb1593d8781386ccfa8bbfc45cac9ba103634e8e686cb370821d48b5aa80c1dd3</citedby><cites>FETCH-LOGICAL-c352t-bb1593d8781386ccfa8bbfc45cac9ba103634e8e686cb370821d48b5aa80c1dd3</cites><orcidid>0000-0001-7967-6924</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-020-04814-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-020-04814-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Qi, Biying</creatorcontrib><creatorcontrib>Yu, Yanping</creatorcontrib><creatorcontrib>You, Qisheng</creatorcontrib><creatorcontrib>Wang, Zengyi</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Liu, Lingzi</creatorcontrib><creatorcontrib>Liu, Wu</creatorcontrib><title>Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH).
Methods
In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed.
Results
The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (
P
< 0.001) and 34.2% (25/73) at 10 months (
P
< 0.001). The incidence was 26.1% (40/153) and 22.0% (9/41) at 4 and 10 months, respectively. OFL appeared at 1 month while disappeared at 4 or 10 months in 8 eyes (50.0%). The presence of OFL at 1 month was negatively associated with IMH diameter (Nagelkerke
R
2
= 0.06;
P
= 0.02). Eyes with OFL at 4 months had better VA at their 4-month visit than eyes without OFL (
P
= 0.02). Eyes with early-developed OFLs had better VA at 10 months than those with later-developed ones (
P
= 0.02). Width of OFL was not associated with postoperative VA at any point.
Conclusions
OFL is not rare in eyes with large IMH after surgery. It can occur gradually and remain during the 10-month follow-up. The presence of OFL appears to have no negative impact on the postoperative VA and it may represent the remodeling of foveal photoreceptors.</description><subject>Acuity</subject><subject>Eye</subject><subject>Hospitals</subject><subject>Macular Holes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Photoreceptors</subject><subject>Regression analysis</subject><subject>Retinal Disorders</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Tomography</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtLAzEUhYMoWKt_wFXAjZtonjOZpZT6AMGNQnchk8m0U9JJTSaF_nszjiC4cHUv93zncDkAXBN8RzAu7yPGnJQIU4wwl4QjcQJmhDOBSkxXp2CGS0qQZHR1Di5i3OLMM0FmYL08eJeGzvdQ9w08dDFpB30ajN_ZCH077jbA1h-sdzpAl4ztzRHqdjzHFNY2HLOcFZ132DWd3-th0xm40yaNlo139hKctdpFe_Uz5-Djcfm-eEavb08vi4dXZJigA6prIirWyFISJgtjWi3rujVcGG2qWhPMCsattEUWa1ZiSUnDZS20ltiQpmFzcDvl7oP_TDYOatdFY53TvfUpKspJxSmTVGT05g-69Sn0-TtFi0KKkhYVzRSdKBN8jMG2ah-6nQ5HRbAau1dT9yp3r767V2M0m0wxw31u6Df6H9cXhdCInw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Qi, Biying</creator><creator>Yu, Yanping</creator><creator>You, Qisheng</creator><creator>Wang, Zengyi</creator><creator>Wang, Jing</creator><creator>Liu, Lingzi</creator><creator>Liu, Wu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7967-6924</orcidid></search><sort><creationdate>20201001</creationdate><title>Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole</title><author>Qi, Biying ; Yu, Yanping ; You, Qisheng ; Wang, Zengyi ; Wang, Jing ; Liu, Lingzi ; Liu, Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-bb1593d8781386ccfa8bbfc45cac9ba103634e8e686cb370821d48b5aa80c1dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acuity</topic><topic>Eye</topic><topic>Hospitals</topic><topic>Macular Holes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Photoreceptors</topic><topic>Regression analysis</topic><topic>Retinal Disorders</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Biying</creatorcontrib><creatorcontrib>Yu, Yanping</creatorcontrib><creatorcontrib>You, Qisheng</creatorcontrib><creatorcontrib>Wang, Zengyi</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Liu, Lingzi</creatorcontrib><creatorcontrib>Liu, Wu</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Biying</au><au>Yu, Yanping</au><au>You, Qisheng</au><au>Wang, Zengyi</au><au>Wang, Jing</au><au>Liu, Lingzi</au><au>Liu, Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>258</volume><issue>10</issue><spage>2117</spage><epage>2124</epage><pages>2117-2124</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH).
Methods
In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed.
Results
The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (
P
< 0.001) and 34.2% (25/73) at 10 months (
P
< 0.001). The incidence was 26.1% (40/153) and 22.0% (9/41) at 4 and 10 months, respectively. OFL appeared at 1 month while disappeared at 4 or 10 months in 8 eyes (50.0%). The presence of OFL at 1 month was negatively associated with IMH diameter (Nagelkerke
R
2
= 0.06;
P
= 0.02). Eyes with OFL at 4 months had better VA at their 4-month visit than eyes without OFL (
P
= 0.02). Eyes with early-developed OFLs had better VA at 10 months than those with later-developed ones (
P
= 0.02). Width of OFL was not associated with postoperative VA at any point.
Conclusions
OFL is not rare in eyes with large IMH after surgery. It can occur gradually and remain during the 10-month follow-up. The presence of OFL appears to have no negative impact on the postoperative VA and it may represent the remodeling of foveal photoreceptors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00417-020-04814-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7967-6924</orcidid></addata></record> |
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| issn | 0721-832X 1435-702X |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acuity Eye Hospitals Macular Holes Medicine Medicine & Public Health Ophthalmology Photoreceptors Regression analysis Retinal Disorders Statistical analysis Surgery Tomography |
| title | Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole |
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