Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma
Objective In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC). Materials and Methods All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were stati...
Gespeichert in:
| Veröffentlicht in: | Oral diseases 2021-03, Vol.27 (2), p.266-276 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 276 |
|---|---|
| container_issue | 2 |
| container_start_page | 266 |
| container_title | Oral diseases |
| container_volume | 27 |
| creator | Soares, Ciro Dantas Cáceres, Cinthia Veronica Bardález López Rodrigues‐Fernandes, Carla Isabelly Lima Morais, Thayná Melo Almeida, Oslei Paes Carvalho, Maria Goretti Freire Fonseca, Felipe Paiva |
| description | Objective
In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).
Materials and Methods
All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow‐up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.
Results
RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p |
| doi_str_mv | 10.1111/odi.13522 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2419406608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2476853903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-6f52ce2d25a8d822c974ed008a6866c2cd7e6b9d5ea57f5f2181b6f38d54eb6f3</originalsourceid><addsrcrecordid>eNp10MtKAzEUBuAgitXqwheQgBtdjOYyyWSW4rVQVETB3ZAmZzTaSWrSon17U1tdCGaTs_jyk_MjtEfJMc3nJFh3TLlgbA1tUUloQRQT63nmoiwE4089tJ3SKyG0qjnbRD3OJKlLorbQw10Mzz6kqTPYdZMQp9obwKHF9483TxTD5yRCSi543IaIX0BbrL3FHswb1hZ8cBab-fd7o6NxPnR6B220epxgd3X30ePlxcPZdTG8vRqcnQ4LwwVnhWwFM8AsE1pZxZipqxIsIUpLJaVhxlYgR7UVoEXVipZRRUey5cqKEhZDHx0ucycxvM8gTZvOJQPjsfYQZqlhJc1bSklUpgd_6GuYRZ9_l1UlleA14VkdLZWJIaUIbTOJrtNx3lDSLKpuctXNd9XZ7q8SZ6MO7K_86TaDkyX4cGOY_5_U3J4PlpFfALeHHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476853903</pqid></control><display><type>article</type><title>Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Soares, Ciro Dantas ; Cáceres, Cinthia Veronica Bardález López ; Rodrigues‐Fernandes, Carla Isabelly ; Lima Morais, Thayná Melo ; Almeida, Oslei Paes ; Carvalho, Maria Goretti Freire ; Fonseca, Felipe Paiva</creator><creatorcontrib>Soares, Ciro Dantas ; Cáceres, Cinthia Veronica Bardález López ; Rodrigues‐Fernandes, Carla Isabelly ; Lima Morais, Thayná Melo ; Almeida, Oslei Paes ; Carvalho, Maria Goretti Freire ; Fonseca, Felipe Paiva</creatorcontrib><description><![CDATA[Objective
In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).
Materials and Methods
All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow‐up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.
Results
RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease‐free survival (p < .0001 and p = .028, respectively) and disease‐specific survival (p < .0001 and p = .018, respectively) rates.
Conclusion
In summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC.]]></description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13522</identifier><identifier>PMID: 32609408</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adenoid ; adenoid cystic carcinoma ; Carcinoma, Adenoid Cystic ; Core Binding Factor Alpha 2 Subunit - genetics ; Head & neck cancer ; Head and Neck Neoplasms ; Humans ; Immunohistochemistry ; Lymph nodes ; Medical records ; Metastases ; Neoplasm Recurrence, Local ; Patients ; Prognosis ; RUNX1 ; Runx1 protein ; salivary gland ; Salivary Gland Neoplasms ; Tumors</subject><ispartof>Oral diseases, 2021-03, Vol.27 (2), p.266-276</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-6f52ce2d25a8d822c974ed008a6866c2cd7e6b9d5ea57f5f2181b6f38d54eb6f3</citedby><cites>FETCH-LOGICAL-c3532-6f52ce2d25a8d822c974ed008a6866c2cd7e6b9d5ea57f5f2181b6f38d54eb6f3</cites><orcidid>0000-0002-6861-6640 ; 0000-0002-9032-2067 ; 0000-0002-6657-4547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13522$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13522$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32609408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, Ciro Dantas</creatorcontrib><creatorcontrib>Cáceres, Cinthia Veronica Bardález López</creatorcontrib><creatorcontrib>Rodrigues‐Fernandes, Carla Isabelly</creatorcontrib><creatorcontrib>Lima Morais, Thayná Melo</creatorcontrib><creatorcontrib>Almeida, Oslei Paes</creatorcontrib><creatorcontrib>Carvalho, Maria Goretti Freire</creatorcontrib><creatorcontrib>Fonseca, Felipe Paiva</creatorcontrib><title>Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description><![CDATA[Objective
In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).
Materials and Methods
All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow‐up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.
Results
RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease‐free survival (p < .0001 and p = .028, respectively) and disease‐specific survival (p < .0001 and p = .018, respectively) rates.
Conclusion
In summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC.]]></description><subject>Adenoid</subject><subject>adenoid cystic carcinoma</subject><subject>Carcinoma, Adenoid Cystic</subject><subject>Core Binding Factor Alpha 2 Subunit - genetics</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Medical records</subject><subject>Metastases</subject><subject>Neoplasm Recurrence, Local</subject><subject>Patients</subject><subject>Prognosis</subject><subject>RUNX1</subject><subject>Runx1 protein</subject><subject>salivary gland</subject><subject>Salivary Gland Neoplasms</subject><subject>Tumors</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAgitXqwheQgBtdjOYyyWSW4rVQVETB3ZAmZzTaSWrSon17U1tdCGaTs_jyk_MjtEfJMc3nJFh3TLlgbA1tUUloQRQT63nmoiwE4089tJ3SKyG0qjnbRD3OJKlLorbQw10Mzz6kqTPYdZMQp9obwKHF9483TxTD5yRCSi543IaIX0BbrL3FHswb1hZ8cBab-fd7o6NxPnR6B220epxgd3X30ePlxcPZdTG8vRqcnQ4LwwVnhWwFM8AsE1pZxZipqxIsIUpLJaVhxlYgR7UVoEXVipZRRUey5cqKEhZDHx0ucycxvM8gTZvOJQPjsfYQZqlhJc1bSklUpgd_6GuYRZ9_l1UlleA14VkdLZWJIaUIbTOJrtNx3lDSLKpuctXNd9XZ7q8SZ6MO7K_86TaDkyX4cGOY_5_U3J4PlpFfALeHHg</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Soares, Ciro Dantas</creator><creator>Cáceres, Cinthia Veronica Bardález López</creator><creator>Rodrigues‐Fernandes, Carla Isabelly</creator><creator>Lima Morais, Thayná Melo</creator><creator>Almeida, Oslei Paes</creator><creator>Carvalho, Maria Goretti Freire</creator><creator>Fonseca, Felipe Paiva</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6861-6640</orcidid><orcidid>https://orcid.org/0000-0002-9032-2067</orcidid><orcidid>https://orcid.org/0000-0002-6657-4547</orcidid></search><sort><creationdate>202103</creationdate><title>Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma</title><author>Soares, Ciro Dantas ; Cáceres, Cinthia Veronica Bardález López ; Rodrigues‐Fernandes, Carla Isabelly ; Lima Morais, Thayná Melo ; Almeida, Oslei Paes ; Carvalho, Maria Goretti Freire ; Fonseca, Felipe Paiva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-6f52ce2d25a8d822c974ed008a6866c2cd7e6b9d5ea57f5f2181b6f38d54eb6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenoid</topic><topic>adenoid cystic carcinoma</topic><topic>Carcinoma, Adenoid Cystic</topic><topic>Core Binding Factor Alpha 2 Subunit - genetics</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Medical records</topic><topic>Metastases</topic><topic>Neoplasm Recurrence, Local</topic><topic>Patients</topic><topic>Prognosis</topic><topic>RUNX1</topic><topic>Runx1 protein</topic><topic>salivary gland</topic><topic>Salivary Gland Neoplasms</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soares, Ciro Dantas</creatorcontrib><creatorcontrib>Cáceres, Cinthia Veronica Bardález López</creatorcontrib><creatorcontrib>Rodrigues‐Fernandes, Carla Isabelly</creatorcontrib><creatorcontrib>Lima Morais, Thayná Melo</creatorcontrib><creatorcontrib>Almeida, Oslei Paes</creatorcontrib><creatorcontrib>Carvalho, Maria Goretti Freire</creatorcontrib><creatorcontrib>Fonseca, Felipe Paiva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, Ciro Dantas</au><au>Cáceres, Cinthia Veronica Bardález López</au><au>Rodrigues‐Fernandes, Carla Isabelly</au><au>Lima Morais, Thayná Melo</au><au>Almeida, Oslei Paes</au><au>Carvalho, Maria Goretti Freire</au><au>Fonseca, Felipe Paiva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2021-03</date><risdate>2021</risdate><volume>27</volume><issue>2</issue><spage>266</spage><epage>276</epage><pages>266-276</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract><![CDATA[Objective
In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).
Materials and Methods
All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow‐up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.
Results
RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease‐free survival (p < .0001 and p = .028, respectively) and disease‐specific survival (p < .0001 and p = .018, respectively) rates.
Conclusion
In summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC.]]></abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32609408</pmid><doi>10.1111/odi.13522</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6861-6640</orcidid><orcidid>https://orcid.org/0000-0002-9032-2067</orcidid><orcidid>https://orcid.org/0000-0002-6657-4547</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1354-523X |
| ispartof | Oral diseases, 2021-03, Vol.27 (2), p.266-276 |
| issn | 1354-523X 1601-0825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2419406608 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adenoid adenoid cystic carcinoma Carcinoma, Adenoid Cystic Core Binding Factor Alpha 2 Subunit - genetics Head & neck cancer Head and Neck Neoplasms Humans Immunohistochemistry Lymph nodes Medical records Metastases Neoplasm Recurrence, Local Patients Prognosis RUNX1 Runx1 protein salivary gland Salivary Gland Neoplasms Tumors |
| title | Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T07%3A06%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20importance%20of%20RUNX1%20expression%20for%20head%20and%20neck%20adenoid%20cystic%20carcinoma&rft.jtitle=Oral%20diseases&rft.au=Soares,%20Ciro%20Dantas&rft.date=2021-03&rft.volume=27&rft.issue=2&rft.spage=266&rft.epage=276&rft.pages=266-276&rft.issn=1354-523X&rft.eissn=1601-0825&rft_id=info:doi/10.1111/odi.13522&rft_dat=%3Cproquest_cross%3E2476853903%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476853903&rft_id=info:pmid/32609408&rfr_iscdi=true |