Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study
•Gabonese pygmies were screened for nasopharyngeal S. pneumoniae colonization in 2011, 2013 and 2017.•Isolates were resistant to tetracycline (36–58%), penicillin (6–39%) and chloramphenicol (3–15%).•The distribution of serotypes was dynamic and very unstable throughout the six years.•The serotype c...
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| Veröffentlicht in: | Vaccine 2020-07, Vol.38 (34), p.5413-5417 |
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| creator | Schaumburg, Frieder Flamen, Arnaud Ehrhardt, Jonas Alabi, Abraham S. van der Linden, Mark P.G. |
| description | •Gabonese pygmies were screened for nasopharyngeal S. pneumoniae colonization in 2011, 2013 and 2017.•Isolates were resistant to tetracycline (36–58%), penicillin (6–39%) and chloramphenicol (3–15%).•The distribution of serotypes was dynamic and very unstable throughout the six years.•The serotype coverage was low for PCV13 (37.3%) and PPSV23 (47.6%).
The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011 (n = 103), 2013 (n = 104) and 2017 (n = 107). Non-duplicate isolates (n = 126) were serotyped and tested for antimicrobial resistance (broth microdilution). At the three sampling time points, resistance rates were highest for tetracycline (36–58%), followed by penicillin (parenteral, meningitis-breakpoints, 6–39%) and chloramphenicol (3–15%). The majority of isolates was non-typeable (NT, n = 18/126, 14.3%) followed by serotype 6B (n = 17/126, 13.5%), 21 and 15A (n = 9/126, 7.1%, each). The distribution of serotypes was highly dynamic as only three serotypes (14, 17F, NT) were detected during all three visits. Resistance rates and serotypes of nasopharyngeal S. pneumoniae markedly changed in the remote Babongo population. This rapid change in serotypes could challenge the selection of pneumococcal vaccine. |
| doi_str_mv | 10.1016/j.vaccine.2020.06.051 |
| format | Article |
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The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011 (n = 103), 2013 (n = 104) and 2017 (n = 107). Non-duplicate isolates (n = 126) were serotyped and tested for antimicrobial resistance (broth microdilution). At the three sampling time points, resistance rates were highest for tetracycline (36–58%), followed by penicillin (parenteral, meningitis-breakpoints, 6–39%) and chloramphenicol (3–15%). The majority of isolates was non-typeable (NT, n = 18/126, 14.3%) followed by serotype 6B (n = 17/126, 13.5%), 21 and 15A (n = 9/126, 7.1%, each). The distribution of serotypes was highly dynamic as only three serotypes (14, 17F, NT) were detected during all three visits. Resistance rates and serotypes of nasopharyngeal S. pneumoniae markedly changed in the remote Babongo population. This rapid change in serotypes could challenge the selection of pneumococcal vaccine.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2020.06.051</identifier><identifier>PMID: 32600915</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Africa ; Age ; Anti-Bacterial Agents - pharmacology ; Antimicrobial agents ; Antimicrobial resistance ; Breakpoints ; Chloramphenicol ; Chloromycetin ; Cohort analysis ; Cohort study ; Colonization ; Drug Resistance, Bacterial ; Ear diseases ; Gabon ; Humans ; Infant ; Meningitis ; Microbial Sensitivity Tests ; Penicillin ; Pneumococcal Infections - epidemiology ; Pneumococcal Vaccines ; Population ; Population dynamics ; Population studies ; Prospective Studies ; Resistance ; Serotype ; Serotypes ; Serotyping ; Streptococcus infections ; Streptococcus pneumoniae ; Vaccines ; Westernization</subject><ispartof>Vaccine, 2020-07, Vol.38 (34), p.5413-5417</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c341t-573cf470918ef680e7eea1b1793e14b8f6bc8fd4b5f1402fc2c2637c53e9a33a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2422717407?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32600915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaumburg, Frieder</creatorcontrib><creatorcontrib>Flamen, Arnaud</creatorcontrib><creatorcontrib>Ehrhardt, Jonas</creatorcontrib><creatorcontrib>Alabi, Abraham S.</creatorcontrib><creatorcontrib>van der Linden, Mark P.G.</creatorcontrib><title>Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•Gabonese pygmies were screened for nasopharyngeal S. pneumoniae colonization in 2011, 2013 and 2017.•Isolates were resistant to tetracycline (36–58%), penicillin (6–39%) and chloramphenicol (3–15%).•The distribution of serotypes was dynamic and very unstable throughout the six years.•The serotype coverage was low for PCV13 (37.3%) and PPSV23 (47.6%).
The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011 (n = 103), 2013 (n = 104) and 2017 (n = 107). Non-duplicate isolates (n = 126) were serotyped and tested for antimicrobial resistance (broth microdilution). At the three sampling time points, resistance rates were highest for tetracycline (36–58%), followed by penicillin (parenteral, meningitis-breakpoints, 6–39%) and chloramphenicol (3–15%). The majority of isolates was non-typeable (NT, n = 18/126, 14.3%) followed by serotype 6B (n = 17/126, 13.5%), 21 and 15A (n = 9/126, 7.1%, each). The distribution of serotypes was highly dynamic as only three serotypes (14, 17F, NT) were detected during all three visits. Resistance rates and serotypes of nasopharyngeal S. pneumoniae markedly changed in the remote Babongo population. This rapid change in serotypes could challenge the selection of pneumococcal vaccine.</description><subject>Africa</subject><subject>Age</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Breakpoints</subject><subject>Chloramphenicol</subject><subject>Chloromycetin</subject><subject>Cohort analysis</subject><subject>Cohort study</subject><subject>Colonization</subject><subject>Drug Resistance, Bacterial</subject><subject>Ear diseases</subject><subject>Gabon</subject><subject>Humans</subject><subject>Infant</subject><subject>Meningitis</subject><subject>Microbial Sensitivity Tests</subject><subject>Penicillin</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Vaccines</subject><subject>Population</subject><subject>Population dynamics</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Resistance</subject><subject>Serotype</subject><subject>Serotypes</subject><subject>Serotyping</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Vaccines</subject><subject>Westernization</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUuP1DAQhC0EYoeFnwCyxIVLQvuRFxc0GvGSVtrDLhI3y3HawqPEDnYy0uyvXw8zcODCqS9fV1dXEfKaQcmA1e_35UEb4zyWHDiUUJdQsSdkw9pGFLxi7VOyAV7LQjL4cUVepLQHgEqw7jm5ErwG6Fi1IeMujMG7B7244Olw9HpyJtFg6d0ScV6CCcasic4e1ymDGqnzVNOIU1iQbm10Rns6h3kdf2t8oFs6x5BmNIs7IDXhZ4gLTcs6HF-SZ1aPCV9d5jX5_vnT_e5rcXP75dtue1MYIdlSVI0wVjbZYIu2bgEbRM161nQCmexbW_emtYPsK8skcGu44bVoTCWw00JocU3enXWzkV8rpkVNLhkcR-0xrElxyTpoq042GX37D7oPa_TZXaY4b1gj4URVZ8rkz1JEq-boJh2PioE61aH26lKHOtWhoFa5jrz35qK-9hMOf7f-5J-Bj2cAcxwHh1El49AbHFzMAaohuP-ceAT-LZ9u</recordid><startdate>20200722</startdate><enddate>20200722</enddate><creator>Schaumburg, Frieder</creator><creator>Flamen, Arnaud</creator><creator>Ehrhardt, Jonas</creator><creator>Alabi, Abraham S.</creator><creator>van der Linden, Mark P.G.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20200722</creationdate><title>Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study</title><author>Schaumburg, Frieder ; Flamen, Arnaud ; Ehrhardt, Jonas ; Alabi, Abraham S. ; van der Linden, Mark P.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-573cf470918ef680e7eea1b1793e14b8f6bc8fd4b5f1402fc2c2637c53e9a33a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Africa</topic><topic>Age</topic><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaumburg, Frieder</au><au>Flamen, Arnaud</au><au>Ehrhardt, Jonas</au><au>Alabi, Abraham S.</au><au>van der Linden, Mark P.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2020-07-22</date><risdate>2020</risdate><volume>38</volume><issue>34</issue><spage>5413</spage><epage>5417</epage><pages>5413-5417</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•Gabonese pygmies were screened for nasopharyngeal S. pneumoniae colonization in 2011, 2013 and 2017.•Isolates were resistant to tetracycline (36–58%), penicillin (6–39%) and chloramphenicol (3–15%).•The distribution of serotypes was dynamic and very unstable throughout the six years.•The serotype coverage was low for PCV13 (37.3%) and PPSV23 (47.6%).
The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011 (n = 103), 2013 (n = 104) and 2017 (n = 107). Non-duplicate isolates (n = 126) were serotyped and tested for antimicrobial resistance (broth microdilution). At the three sampling time points, resistance rates were highest for tetracycline (36–58%), followed by penicillin (parenteral, meningitis-breakpoints, 6–39%) and chloramphenicol (3–15%). The majority of isolates was non-typeable (NT, n = 18/126, 14.3%) followed by serotype 6B (n = 17/126, 13.5%), 21 and 15A (n = 9/126, 7.1%, each). The distribution of serotypes was highly dynamic as only three serotypes (14, 17F, NT) were detected during all three visits. Resistance rates and serotypes of nasopharyngeal S. pneumoniae markedly changed in the remote Babongo population. This rapid change in serotypes could challenge the selection of pneumococcal vaccine.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32600915</pmid><doi>10.1016/j.vaccine.2020.06.051</doi><tpages>5</tpages></addata></record> |
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| subjects | Africa Age Anti-Bacterial Agents - pharmacology Antimicrobial agents Antimicrobial resistance Breakpoints Chloramphenicol Chloromycetin Cohort analysis Cohort study Colonization Drug Resistance, Bacterial Ear diseases Gabon Humans Infant Meningitis Microbial Sensitivity Tests Penicillin Pneumococcal Infections - epidemiology Pneumococcal Vaccines Population Population dynamics Population studies Prospective Studies Resistance Serotype Serotypes Serotyping Streptococcus infections Streptococcus pneumoniae Vaccines Westernization |
| title | Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study |
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