Breast cancer spinal metastases: Prognostic factors affecting survival after surgery. A retrospective study
•Retrospective cohort study of patients affected by breast cancer spinal metastases surgically treated.•Concurrent bone metastases and preoperative neurological impairment are independent prognostic factors.•The study of prognostic factors is relevant to evaluate the most appropriate surgical treatm...
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| Veröffentlicht in: | Journal of clinical neuroscience 2020-08, Vol.78, p.73-78 |
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| container_title | Journal of clinical neuroscience |
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| creator | Terzi, Silvia Trentin, Federica Carretta, Elisa Pipola, Valerio Ghermandi, Riccardo Barbanti Bròdano, Giovanni Ferrari, Cristina Griffoni, Cristiana Gasbarrini, Alessandro |
| description | •Retrospective cohort study of patients affected by breast cancer spinal metastases surgically treated.•Concurrent bone metastases and preoperative neurological impairment are independent prognostic factors.•The study of prognostic factors is relevant to evaluate the most appropriate surgical treatment.
Breast cancer spinal metastases (BCSM) are common and require proper treatment that leads to an improvement of the quality of life and contributes to the quod vitam prognosis. Surgical treatment is often required for intractable pain, spinal cord compression or spinal instability.
The aim of this retrospective study is to identify which prognostic factors could affect postoperative overall survival in patients affected by BCSM.
We report a retrospective cohort study of patients with BCSM, surgically treated from September 2009 to May 2018. Demographic and clinical data were collected. Kaplan-Meier method was used to estimate overall survival, and the log-rank test was used to compare survival curves.
A total of 77 patients were studied. The median age at the time of surgery was 54 years. The median follow-up was 49 months. The 3-year and 5-year overall survival rates were 61% (95%CI: 47.5–72.1) and 43.3% (95%CI: 28.8–57.1). Metastatic bone disease (p = 0.0196), preoperative neurological impairment (p = 0.0029), Karnofsky status |
| doi_str_mv | 10.1016/j.jocn.2020.06.010 |
| format | Article |
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Breast cancer spinal metastases (BCSM) are common and require proper treatment that leads to an improvement of the quality of life and contributes to the quod vitam prognosis. Surgical treatment is often required for intractable pain, spinal cord compression or spinal instability.
The aim of this retrospective study is to identify which prognostic factors could affect postoperative overall survival in patients affected by BCSM.
We report a retrospective cohort study of patients with BCSM, surgically treated from September 2009 to May 2018. Demographic and clinical data were collected. Kaplan-Meier method was used to estimate overall survival, and the log-rank test was used to compare survival curves.
A total of 77 patients were studied. The median age at the time of surgery was 54 years. The median follow-up was 49 months. The 3-year and 5-year overall survival rates were 61% (95%CI: 47.5–72.1) and 43.3% (95%CI: 28.8–57.1). Metastatic bone disease (p = 0.0196), preoperative neurological impairment (p = 0.0029), Karnofsky status <70 (p = 0.0241) reduce survival. With multivariate analysis, the effect of Karnofsky score loses statistical significance.
The presence of concurrent bone metastases and a preoperative neurological deficit are independent prognostic factors. Therapeutic choices are based on a multidisciplinary assessment that takes into consideration several factors, including an accurate study of prognostic factors.</description><identifier>ISSN: 0967-5868</identifier><identifier>ISSN: 1532-2653</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2020.06.010</identifier><identifier>PMID: 32600973</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Aged ; Breast cancer ; Breast Neoplasms ; Female ; Humans ; Karnofsky Performance Status ; Middle Aged ; Pain, Intractable - surgery ; Prognosis ; Quality of Life ; Retrospective Studies ; Spinal Cord Compression - surgery ; Spinal metastasis ; Spinal Neoplasms - diagnosis ; Spinal Neoplasms - mortality ; Spinal Neoplasms - secondary ; Spinal Neoplasms - surgery ; Spine - surgery ; Surgery ; Survival analysis ; Survival Rate</subject><ispartof>Journal of clinical neuroscience, 2020-08, Vol.78, p.73-78</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3f5710fbf127f1dcab98d84abb6a237714f24db2dd677948fa20213327f5c7523</citedby><cites>FETCH-LOGICAL-c356t-3f5710fbf127f1dcab98d84abb6a237714f24db2dd677948fa20213327f5c7523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0967586820313187$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32600973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terzi, Silvia</creatorcontrib><creatorcontrib>Trentin, Federica</creatorcontrib><creatorcontrib>Carretta, Elisa</creatorcontrib><creatorcontrib>Pipola, Valerio</creatorcontrib><creatorcontrib>Ghermandi, Riccardo</creatorcontrib><creatorcontrib>Barbanti Bròdano, Giovanni</creatorcontrib><creatorcontrib>Ferrari, Cristina</creatorcontrib><creatorcontrib>Griffoni, Cristiana</creatorcontrib><creatorcontrib>Gasbarrini, Alessandro</creatorcontrib><title>Breast cancer spinal metastases: Prognostic factors affecting survival after surgery. A retrospective study</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>•Retrospective cohort study of patients affected by breast cancer spinal metastases surgically treated.•Concurrent bone metastases and preoperative neurological impairment are independent prognostic factors.•The study of prognostic factors is relevant to evaluate the most appropriate surgical treatment.
Breast cancer spinal metastases (BCSM) are common and require proper treatment that leads to an improvement of the quality of life and contributes to the quod vitam prognosis. Surgical treatment is often required for intractable pain, spinal cord compression or spinal instability.
The aim of this retrospective study is to identify which prognostic factors could affect postoperative overall survival in patients affected by BCSM.
We report a retrospective cohort study of patients with BCSM, surgically treated from September 2009 to May 2018. Demographic and clinical data were collected. Kaplan-Meier method was used to estimate overall survival, and the log-rank test was used to compare survival curves.
A total of 77 patients were studied. The median age at the time of surgery was 54 years. The median follow-up was 49 months. The 3-year and 5-year overall survival rates were 61% (95%CI: 47.5–72.1) and 43.3% (95%CI: 28.8–57.1). Metastatic bone disease (p = 0.0196), preoperative neurological impairment (p = 0.0029), Karnofsky status <70 (p = 0.0241) reduce survival. With multivariate analysis, the effect of Karnofsky score loses statistical significance.
The presence of concurrent bone metastases and a preoperative neurological deficit are independent prognostic factors. Therapeutic choices are based on a multidisciplinary assessment that takes into consideration several factors, including an accurate study of prognostic factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms</subject><subject>Female</subject><subject>Humans</subject><subject>Karnofsky Performance Status</subject><subject>Middle Aged</subject><subject>Pain, Intractable - surgery</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Spinal Cord Compression - surgery</subject><subject>Spinal metastasis</subject><subject>Spinal Neoplasms - diagnosis</subject><subject>Spinal Neoplasms - mortality</subject><subject>Spinal Neoplasms - secondary</subject><subject>Spinal Neoplasms - surgery</subject><subject>Spine - surgery</subject><subject>Surgery</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><issn>0967-5868</issn><issn>1532-2653</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaTZp_0APRcde7OjDluySSxKaDwi0h_YsZGm0aLtrbzXywv77ymzSY04axPO-zDyEfOas5oyrq029mdxYCyZYzVTNOHtHVryVohKqlWdkxXqlq7ZT3Tm5QNwwxvpGsg_kXApVZi1X5M9tAouZOjs6SBT3cbRbuoNcPi0CfqM_07QeJ8zR0WBdnhJSGwK4HMc1xTkd4qEkbMhLfE5rSMea3tAEOU24X7gDUMyzP34k74PdInx6eS_J7_vvv-4eq-cfD093N8-Vk63KlQyt5iwMgQsduHd26DvfNXYYlBVSa94E0fhBeK-07psu2GKAS1no1ulWyEvy9dS7T9PfGTCbXUQH260dYZrRiIb3rGt11xRUnFBXlsUEwexT3Nl0NJyZRbLZmEWyWSQbpkyRXEJfXvrnYQf-f-TVagGuTwCUKw8RkkEXoQj2MRUhxk_xrf5_jBGPaQ</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Terzi, Silvia</creator><creator>Trentin, Federica</creator><creator>Carretta, Elisa</creator><creator>Pipola, Valerio</creator><creator>Ghermandi, Riccardo</creator><creator>Barbanti Bròdano, Giovanni</creator><creator>Ferrari, Cristina</creator><creator>Griffoni, Cristiana</creator><creator>Gasbarrini, Alessandro</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>Breast cancer spinal metastases: Prognostic factors affecting survival after surgery. A retrospective study</title><author>Terzi, Silvia ; Trentin, Federica ; Carretta, Elisa ; Pipola, Valerio ; Ghermandi, Riccardo ; Barbanti Bròdano, Giovanni ; Ferrari, Cristina ; Griffoni, Cristiana ; Gasbarrini, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3f5710fbf127f1dcab98d84abb6a237714f24db2dd677948fa20213327f5c7523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms</topic><topic>Female</topic><topic>Humans</topic><topic>Karnofsky Performance Status</topic><topic>Middle Aged</topic><topic>Pain, Intractable - surgery</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Spinal Cord Compression - surgery</topic><topic>Spinal metastasis</topic><topic>Spinal Neoplasms - diagnosis</topic><topic>Spinal Neoplasms - mortality</topic><topic>Spinal Neoplasms - secondary</topic><topic>Spinal Neoplasms - surgery</topic><topic>Spine - surgery</topic><topic>Surgery</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terzi, Silvia</creatorcontrib><creatorcontrib>Trentin, Federica</creatorcontrib><creatorcontrib>Carretta, Elisa</creatorcontrib><creatorcontrib>Pipola, Valerio</creatorcontrib><creatorcontrib>Ghermandi, Riccardo</creatorcontrib><creatorcontrib>Barbanti Bròdano, Giovanni</creatorcontrib><creatorcontrib>Ferrari, Cristina</creatorcontrib><creatorcontrib>Griffoni, Cristiana</creatorcontrib><creatorcontrib>Gasbarrini, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terzi, Silvia</au><au>Trentin, Federica</au><au>Carretta, Elisa</au><au>Pipola, Valerio</au><au>Ghermandi, Riccardo</au><au>Barbanti Bròdano, Giovanni</au><au>Ferrari, Cristina</au><au>Griffoni, Cristiana</au><au>Gasbarrini, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast cancer spinal metastases: Prognostic factors affecting survival after surgery. A retrospective study</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2020-08</date><risdate>2020</risdate><volume>78</volume><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>0967-5868</issn><issn>1532-2653</issn><eissn>1532-2653</eissn><abstract>•Retrospective cohort study of patients affected by breast cancer spinal metastases surgically treated.•Concurrent bone metastases and preoperative neurological impairment are independent prognostic factors.•The study of prognostic factors is relevant to evaluate the most appropriate surgical treatment.
Breast cancer spinal metastases (BCSM) are common and require proper treatment that leads to an improvement of the quality of life and contributes to the quod vitam prognosis. Surgical treatment is often required for intractable pain, spinal cord compression or spinal instability.
The aim of this retrospective study is to identify which prognostic factors could affect postoperative overall survival in patients affected by BCSM.
We report a retrospective cohort study of patients with BCSM, surgically treated from September 2009 to May 2018. Demographic and clinical data were collected. Kaplan-Meier method was used to estimate overall survival, and the log-rank test was used to compare survival curves.
A total of 77 patients were studied. The median age at the time of surgery was 54 years. The median follow-up was 49 months. The 3-year and 5-year overall survival rates were 61% (95%CI: 47.5–72.1) and 43.3% (95%CI: 28.8–57.1). Metastatic bone disease (p = 0.0196), preoperative neurological impairment (p = 0.0029), Karnofsky status <70 (p = 0.0241) reduce survival. With multivariate analysis, the effect of Karnofsky score loses statistical significance.
The presence of concurrent bone metastases and a preoperative neurological deficit are independent prognostic factors. Therapeutic choices are based on a multidisciplinary assessment that takes into consideration several factors, including an accurate study of prognostic factors.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>32600973</pmid><doi>10.1016/j.jocn.2020.06.010</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Breast cancer Breast Neoplasms Female Humans Karnofsky Performance Status Middle Aged Pain, Intractable - surgery Prognosis Quality of Life Retrospective Studies Spinal Cord Compression - surgery Spinal metastasis Spinal Neoplasms - diagnosis Spinal Neoplasms - mortality Spinal Neoplasms - secondary Spinal Neoplasms - surgery Spine - surgery Surgery Survival analysis Survival Rate |
| title | Breast cancer spinal metastases: Prognostic factors affecting survival after surgery. A retrospective study |
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