Development of disturbance of consciousness is associated with increased severity in acute pancreatitis
Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP. From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collec...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020-07, Vol.20 (5), p.806-812 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | Hágendorn, Roland Vincze, Áron Izbéki, Ferenc Gajdán, László Gódi, Szilárd Illés, Anita Sarlós, Patrícia Farkas, Nelli Erőss, Bálint Lillik, Veronika Illés, Dóra Varjú, Péter Márta, Katalin Török, Imola Papp, Mária Vitális, Zsuzsanna Bod, Barnabás Hamvas, József Szepes, Zoltán Takács, Tamás Czakó, László Márton, Zsolt Szentesi, Andrea Párniczky, Andrea Hegyi, Péter Mikó, Alexandra |
| description | Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP.
From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collected cases were analyzed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used.
From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p |
| doi_str_mv | 10.1016/j.pan.2020.05.009 |
| format | Article |
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From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collected cases were analyzed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used.
From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p < 0.001), higher mortality (14.9% vs. 1.7%, p < 0.001), and a longer length of hospitalization (LOH) (Me = 11; IQR: 8–17 days vs. Me = 9; IQR: 6–13 days, p = 0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p < 0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7–20 days vs. Me:9.5; IQR:8–15.5 days, p = 0.119).
DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2020.05.009</identifier><language>eng</language><publisher>Philadelphia: Elsevier B.V</publisher><subject>Acute pancreatitis ; Age ; Alcohol ; Alcohol withdrawal ; Consciousness ; Delirium ; Disturbance of consciousness ; Etiology ; Hospitalization ; Mortality ; Older people ; Pancreas ; Pancreatitis ; Statistical analysis</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020-07, Vol.20 (5), p.806-812</ispartof><rights>2020 The Authors</rights><rights>2020. IAP and EPC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-bebb24055e8319a2f97892d1637dfbfcd0771a93c9e9c180589ac4a0c137bc233</citedby><cites>FETCH-LOGICAL-c401t-bebb24055e8319a2f97892d1637dfbfcd0771a93c9e9c180589ac4a0c137bc233</cites><orcidid>0000-0003-2097-6927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Hágendorn, Roland</creatorcontrib><creatorcontrib>Vincze, Áron</creatorcontrib><creatorcontrib>Izbéki, Ferenc</creatorcontrib><creatorcontrib>Gajdán, László</creatorcontrib><creatorcontrib>Gódi, Szilárd</creatorcontrib><creatorcontrib>Illés, Anita</creatorcontrib><creatorcontrib>Sarlós, Patrícia</creatorcontrib><creatorcontrib>Farkas, Nelli</creatorcontrib><creatorcontrib>Erőss, Bálint</creatorcontrib><creatorcontrib>Lillik, Veronika</creatorcontrib><creatorcontrib>Illés, Dóra</creatorcontrib><creatorcontrib>Varjú, Péter</creatorcontrib><creatorcontrib>Márta, Katalin</creatorcontrib><creatorcontrib>Török, Imola</creatorcontrib><creatorcontrib>Papp, Mária</creatorcontrib><creatorcontrib>Vitális, Zsuzsanna</creatorcontrib><creatorcontrib>Bod, Barnabás</creatorcontrib><creatorcontrib>Hamvas, József</creatorcontrib><creatorcontrib>Szepes, Zoltán</creatorcontrib><creatorcontrib>Takács, Tamás</creatorcontrib><creatorcontrib>Czakó, László</creatorcontrib><creatorcontrib>Márton, Zsolt</creatorcontrib><creatorcontrib>Szentesi, Andrea</creatorcontrib><creatorcontrib>Párniczky, Andrea</creatorcontrib><creatorcontrib>Hegyi, Péter</creatorcontrib><creatorcontrib>Mikó, Alexandra</creatorcontrib><title>Development of disturbance of consciousness is associated with increased severity in acute pancreatitis</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><description>Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP.
From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collected cases were analyzed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used.
From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p < 0.001), higher mortality (14.9% vs. 1.7%, p < 0.001), and a longer length of hospitalization (LOH) (Me = 11; IQR: 8–17 days vs. Me = 9; IQR: 6–13 days, p = 0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p < 0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7–20 days vs. Me:9.5; IQR:8–15.5 days, p = 0.119).
DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.</description><subject>Acute pancreatitis</subject><subject>Age</subject><subject>Alcohol</subject><subject>Alcohol withdrawal</subject><subject>Consciousness</subject><subject>Delirium</subject><subject>Disturbance of consciousness</subject><subject>Etiology</subject><subject>Hospitalization</subject><subject>Mortality</subject><subject>Older people</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Statistical analysis</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE9PwzAMxSsEEmPwAbhV4sJlxU7atREnNP5KSFzgHKWpC5m2ZsQpiG9PpiEOHDjZTn7P8ntZdopQIOD8YllszFAIEFBAVQCovWyCpShnUiHu__YgD7Mj5iWAEIhqkr1e0wet_GZNQ8x9n3eO4xhaM1jajtYPbJ0feSDm3HFumL11JlKXf7r4lrvBBjKcRk6Lgotf6Sk3doyUp4u2n9FFx8fZQW9WTCc_dZq93N48L-5nj093D4urx5ktAeOspbYVJVQVNRKVEb2qGyU6nMu669vedlDXaJS0ipTFBqpGGVsasCjr1gopp9n5bu8m-PeROOq1Y0urlRko2dCixKaWomlUQs_-oEs_hiFdlygJsq5LhEThjrLBMwfq9Sa4tQlfGkFvo9dLnYzqbfQaKp2iT5rLnYaS0w9HQacQKUXauUA26s67f9TfCHyNOg</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Hágendorn, Roland</creator><creator>Vincze, Áron</creator><creator>Izbéki, Ferenc</creator><creator>Gajdán, László</creator><creator>Gódi, Szilárd</creator><creator>Illés, Anita</creator><creator>Sarlós, Patrícia</creator><creator>Farkas, Nelli</creator><creator>Erőss, Bálint</creator><creator>Lillik, Veronika</creator><creator>Illés, Dóra</creator><creator>Varjú, Péter</creator><creator>Márta, Katalin</creator><creator>Török, Imola</creator><creator>Papp, Mária</creator><creator>Vitális, Zsuzsanna</creator><creator>Bod, Barnabás</creator><creator>Hamvas, József</creator><creator>Szepes, Zoltán</creator><creator>Takács, Tamás</creator><creator>Czakó, László</creator><creator>Márton, Zsolt</creator><creator>Szentesi, Andrea</creator><creator>Párniczky, Andrea</creator><creator>Hegyi, Péter</creator><creator>Mikó, Alexandra</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2097-6927</orcidid></search><sort><creationdate>202007</creationdate><title>Development of disturbance of consciousness is associated with increased severity in acute pancreatitis</title><author>Hágendorn, Roland ; Vincze, Áron ; Izbéki, Ferenc ; Gajdán, László ; Gódi, Szilárd ; Illés, Anita ; Sarlós, Patrícia ; Farkas, Nelli ; Erőss, Bálint ; Lillik, Veronika ; Illés, Dóra ; Varjú, Péter ; Márta, Katalin ; Török, Imola ; Papp, Mária ; Vitális, Zsuzsanna ; Bod, Barnabás ; Hamvas, József ; Szepes, Zoltán ; Takács, Tamás ; Czakó, László ; Márton, Zsolt ; Szentesi, Andrea ; Párniczky, Andrea ; Hegyi, Péter ; Mikó, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-bebb24055e8319a2f97892d1637dfbfcd0771a93c9e9c180589ac4a0c137bc233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute pancreatitis</topic><topic>Age</topic><topic>Alcohol</topic><topic>Alcohol withdrawal</topic><topic>Consciousness</topic><topic>Delirium</topic><topic>Disturbance of consciousness</topic><topic>Etiology</topic><topic>Hospitalization</topic><topic>Mortality</topic><topic>Older people</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hágendorn, Roland</creatorcontrib><creatorcontrib>Vincze, Áron</creatorcontrib><creatorcontrib>Izbéki, Ferenc</creatorcontrib><creatorcontrib>Gajdán, László</creatorcontrib><creatorcontrib>Gódi, Szilárd</creatorcontrib><creatorcontrib>Illés, Anita</creatorcontrib><creatorcontrib>Sarlós, Patrícia</creatorcontrib><creatorcontrib>Farkas, Nelli</creatorcontrib><creatorcontrib>Erőss, Bálint</creatorcontrib><creatorcontrib>Lillik, Veronika</creatorcontrib><creatorcontrib>Illés, Dóra</creatorcontrib><creatorcontrib>Varjú, Péter</creatorcontrib><creatorcontrib>Márta, Katalin</creatorcontrib><creatorcontrib>Török, Imola</creatorcontrib><creatorcontrib>Papp, Mária</creatorcontrib><creatorcontrib>Vitális, Zsuzsanna</creatorcontrib><creatorcontrib>Bod, Barnabás</creatorcontrib><creatorcontrib>Hamvas, József</creatorcontrib><creatorcontrib>Szepes, Zoltán</creatorcontrib><creatorcontrib>Takács, Tamás</creatorcontrib><creatorcontrib>Czakó, László</creatorcontrib><creatorcontrib>Márton, Zsolt</creatorcontrib><creatorcontrib>Szentesi, Andrea</creatorcontrib><creatorcontrib>Párniczky, Andrea</creatorcontrib><creatorcontrib>Hegyi, Péter</creatorcontrib><creatorcontrib>Mikó, Alexandra</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hágendorn, Roland</au><au>Vincze, Áron</au><au>Izbéki, Ferenc</au><au>Gajdán, László</au><au>Gódi, Szilárd</au><au>Illés, Anita</au><au>Sarlós, Patrícia</au><au>Farkas, Nelli</au><au>Erőss, Bálint</au><au>Lillik, Veronika</au><au>Illés, Dóra</au><au>Varjú, Péter</au><au>Márta, Katalin</au><au>Török, Imola</au><au>Papp, Mária</au><au>Vitális, Zsuzsanna</au><au>Bod, Barnabás</au><au>Hamvas, József</au><au>Szepes, Zoltán</au><au>Takács, Tamás</au><au>Czakó, László</au><au>Márton, Zsolt</au><au>Szentesi, Andrea</au><au>Párniczky, Andrea</au><au>Hegyi, Péter</au><au>Mikó, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of disturbance of consciousness is associated with increased severity in acute pancreatitis</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><date>2020-07</date><risdate>2020</risdate><volume>20</volume><issue>5</issue><spage>806</spage><epage>812</epage><pages>806-812</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP.
From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collected cases were analyzed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used.
From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p < 0.001), higher mortality (14.9% vs. 1.7%, p < 0.001), and a longer length of hospitalization (LOH) (Me = 11; IQR: 8–17 days vs. Me = 9; IQR: 6–13 days, p = 0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p < 0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7–20 days vs. Me:9.5; IQR:8–15.5 days, p = 0.119).
DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.</abstract><cop>Philadelphia</cop><pub>Elsevier B.V</pub><doi>10.1016/j.pan.2020.05.009</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2097-6927</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020-07, Vol.20 (5), p.806-812 |
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| source | Alma/SFX Local Collection |
| subjects | Acute pancreatitis Age Alcohol Alcohol withdrawal Consciousness Delirium Disturbance of consciousness Etiology Hospitalization Mortality Older people Pancreas Pancreatitis Statistical analysis |
| title | Development of disturbance of consciousness is associated with increased severity in acute pancreatitis |
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