ABO incompatibile graft management in pediatric transplantation
Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party invest...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2021-01, Vol.56 (1), p.84-90 |
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| creator | Balduzzi, Adriana Bönig, Halvard Jarisch, Andrea Nava, Tiago Ansari, Marc Cattoni, Alessandro Prunotto, Giulia Lucchini, Giovanna Krivan, Gergely Matic, Toni Kalwak, Krzyzstof Yesilipek, Akif Ifversen, Marianne Svec, Peter Buechner, Jochen Vettenranta, Kim Meisel, Roland Lawitschka, Anita Peters, Christina Gibson, Brenda Dalissier, Arnaud Corbacioglu, Selim Willasch, André Dalle, Jean-Hugues Bader, Peter |
| description | Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor’s RBCs have antigens missing on the recipient’s cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed. |
| doi_str_mv | 10.1038/s41409-020-0981-7 |
| format | Article |
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The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor’s RBCs have antigens missing on the recipient’s cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-020-0981-7</identifier><identifier>PMID: 32594103</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/1541 ; 692/699/249 ; ABO system ; Antigens ; Aplasia ; Bone marrow ; Cell Biology ; Cell surface ; Centrifugation ; Children ; Compatibility testing (Hematology) ; Complications ; Complications and side effects ; Depletion ; Erythropoiesis ; Grafting ; Hematology ; Hematopoietic stem cells ; Incompatibility ; Internal Medicine ; Management ; Medicine ; Medicine & Public Health ; Pediatrics ; Peripheral blood ; Polls & surveys ; Public Health ; Stem cell transplantation ; Stem Cells ; Surgery ; Transplantation</subject><ispartof>Bone marrow transplantation (Basingstoke), 2021-01, Vol.56 (1), p.84-90</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-5950cff9780e86b6a9c2605327a67359ca7d0ec3d5a6173146d47fc30ca5a54e3</citedby><cites>FETCH-LOGICAL-c579t-5950cff9780e86b6a9c2605327a67359ca7d0ec3d5a6173146d47fc30ca5a54e3</cites><orcidid>0000-0003-0369-8515 ; 0000-0001-6798-8998 ; 0000-0003-1174-5799 ; 0000-0002-5879-0610 ; 0000-0002-8150-5478 ; 0000-0001-5230-0628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32594103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balduzzi, Adriana</creatorcontrib><creatorcontrib>Bönig, Halvard</creatorcontrib><creatorcontrib>Jarisch, Andrea</creatorcontrib><creatorcontrib>Nava, Tiago</creatorcontrib><creatorcontrib>Ansari, Marc</creatorcontrib><creatorcontrib>Cattoni, Alessandro</creatorcontrib><creatorcontrib>Prunotto, Giulia</creatorcontrib><creatorcontrib>Lucchini, Giovanna</creatorcontrib><creatorcontrib>Krivan, Gergely</creatorcontrib><creatorcontrib>Matic, Toni</creatorcontrib><creatorcontrib>Kalwak, Krzyzstof</creatorcontrib><creatorcontrib>Yesilipek, Akif</creatorcontrib><creatorcontrib>Ifversen, Marianne</creatorcontrib><creatorcontrib>Svec, Peter</creatorcontrib><creatorcontrib>Buechner, Jochen</creatorcontrib><creatorcontrib>Vettenranta, Kim</creatorcontrib><creatorcontrib>Meisel, Roland</creatorcontrib><creatorcontrib>Lawitschka, Anita</creatorcontrib><creatorcontrib>Peters, Christina</creatorcontrib><creatorcontrib>Gibson, Brenda</creatorcontrib><creatorcontrib>Dalissier, Arnaud</creatorcontrib><creatorcontrib>Corbacioglu, Selim</creatorcontrib><creatorcontrib>Willasch, André</creatorcontrib><creatorcontrib>Dalle, Jean-Hugues</creatorcontrib><creatorcontrib>Bader, Peter</creatorcontrib><creatorcontrib>EBMT Pediatric Diseases Working Party</creatorcontrib><creatorcontrib>on behalf of the EBMT Pediatric Diseases Working Party</creatorcontrib><title>ABO incompatibile graft management in pediatric transplantation</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor’s RBCs have antigens missing on the recipient’s cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.</description><subject>692/699/1541</subject><subject>692/699/249</subject><subject>ABO system</subject><subject>Antigens</subject><subject>Aplasia</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Cell surface</subject><subject>Centrifugation</subject><subject>Children</subject><subject>Compatibility testing (Hematology)</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Depletion</subject><subject>Erythropoiesis</subject><subject>Grafting</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Incompatibility</subject><subject>Internal Medicine</subject><subject>Management</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatrics</subject><subject>Peripheral blood</subject><subject>Polls & surveys</subject><subject>Public Health</subject><subject>Stem cell 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| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2021-01, Vol.56 (1), p.84-90 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2418728898 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 692/699/1541 692/699/249 ABO system Antigens Aplasia Bone marrow Cell Biology Cell surface Centrifugation Children Compatibility testing (Hematology) Complications Complications and side effects Depletion Erythropoiesis Grafting Hematology Hematopoietic stem cells Incompatibility Internal Medicine Management Medicine Medicine & Public Health Pediatrics Peripheral blood Polls & surveys Public Health Stem cell transplantation Stem Cells Surgery Transplantation |
| title | ABO incompatibile graft management in pediatric transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T10%3A09%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ABO%20incompatibile%20graft%20management%20in%20pediatric%20transplantation&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Balduzzi,%20Adriana&rft.aucorp=EBMT%20Pediatric%20Diseases%20Working%20Party&rft.date=2021-01-01&rft.volume=56&rft.issue=1&rft.spage=84&rft.epage=90&rft.pages=84-90&rft.issn=0268-3369&rft.eissn=1476-5365&rft_id=info:doi/10.1038/s41409-020-0981-7&rft_dat=%3Cgale_proqu%3EA650177224%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476372161&rft_id=info:pmid/32594103&rft_galeid=A650177224&rfr_iscdi=true |