New 1,2,3‐triazole–(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation

A new series of 1,2,3‐triazole–(thio)barbituric acid hybrids 8a–n was designed and synthesized on the basis of potent pharmacophores with urease inhibitory activity. Therefore, these compounds were evaluated against Helicobacter pylori urease. The obtained result demonstrated that all the synthesize...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2020-09, Vol.353 (9), p.e2000023-n/a
Hauptverfasser:	Asgari, Mohammad S., Azizian, Homa, Nazari Montazer, Mohammad, Mohammadi‐Khanaposhtani, Maryam, Asadi, Mehdi, Sepehri, Saghi, Ranjbar, Parviz R., Rahimi, Rahmatollah, Biglar, Mahmood, Larijani, Bagher, Amanlou, Massoud, Mahdavi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3‐triazole barbituric acid docking study molecular dynamic simulation thiobarbituric acid urease inhibition
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!