Inhibitory interneurons regulate phasic activity of noradrenergic neurons in the mouse locus coeruleus and functional implications

Key points The locus coeruleus (LC) contains noradrenergic (NA) neurons that respond to novel stimuli in the environment with phasic activation to initiate an orienting response; phasic LC activation is also triggered by stimuli, representing the outcome of task‐related decision processes, to facili...

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Veröffentlicht in:	The Journal of physiology 2020-09, Vol.598 (18), p.4003-4029
Hauptverfasser:	Kuo, Chao‐Cheng, Hsieh, Jung‐Chien, Tsai, Hsing‐Chun, Kuo, Yu‐Shan, Yau, Hau‐Jie, Chen, Chih‐Cheng, Chen, Ruei‐Feng, Yang, Hsiu‐Wen, Min, Ming‐Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adrenergic Neurons Animals Axons Brain slice preparation chemogenetic Cortex (frontal) Decision making Environmental effects Gating Interneurons Locus Coeruleus Mental task performance Mice Norepinephrine optogenetic orbitofrontal cortex Orientation behavior prelimbic cortex prepulse inhibition Reinforcement whole‐cell patch γ-Aminobutyric acid
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