The miR‐140‐5p/KLF9/KCNQ1 axis promotes the progression of renal cell carcinoma

Although renal cell carcinoma (RCC) is a common malignant urological cancer, its pathogenesis remains unclear. Previous studies have indicated that miR‐140‐5p acts as a tumor suppressor in various tumors, including bladder cancer, hepatocellular carcinoma, and gastric cancer, but its biological func...

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Veröffentlicht in:	The FASEB journal 2020-08, Vol.34 (8), p.10623-10639
Hauptverfasser:	Huang, Chenchen, Li, Jianfa, Zhang, Xiaoting, Xiong, Tiefu, Ye, Jing, Yu, Jing, Gui, Yaoting
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell Line Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Disease Progression Down-Regulation - genetics Female Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor - physiology HEK293 Cells Humans KCNQ1 KCNQ1 Potassium Channel - genetics Kidney Neoplasms - genetics Kidney Neoplasms - pathology KLF9 Kruppel-Like Transcription Factors - genetics Liver Neoplasms - genetics Liver Neoplasms - pathology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics Middle Aged miR‐140‐5p proliferation/invasion/metastasis renal cell carcinoma Up-Regulation - genetics
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