Risk factors and comorbidities associated with severe aortic stenosis: a case-control study

Risk factors and comorbidities associated with severe aortic stenosis: a case-control study

Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Revista clínica espanõla 2021-05, Vol.221 (5), p.249-257
Hauptverfasser: Gracia Baena, J M, Calaf Vall, I, Zielonka, M, Marsal Mora, J R, Godoy, P, Worner Diz, F
Format: Artikel
Sprache:eng ; spa
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 257
container_issue 5
container_start_page 249
container_title Revista clínica espanõla
container_volume 221
creator Gracia Baena, J M
Calaf Vall, I
Zielonka, M
Marsal Mora, J R
Godoy, P
Worner Diz, F
description Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region. We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models. The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p
doi_str_mv 10.1016/j.rce.2020.01.010
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2418132570</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2418132570</sourcerecordid><originalsourceid>FETCH-LOGICAL-p126t-2a20194fea65705aeaa76a7a6af9e0fbb8d6ba10c734b74e5cdc279922e682733</originalsourceid><addsrcrecordid>eNo1UE1LxDAUDIK46-oP8CI5emlN0jZpvcniFywIoicP5TV9xaxts-alyv57C66PgYGZYWAeYxdSpFJIfb1Ng8VUCSVSIWeII7aUhSkTWWqxYKdEWyFUkcnshC0yVVRyviV7f3H0yTuw0QfiMLbc-sGHxrUuOpwVIm8dRGz5j4sfnPAbA3LwITrLKeLoydENB26BMLF-jMH3szG1-zN23EFPeH7gFXu7v3tdPyab54en9e0m2UmlY6JACVnlHYIujCgAAYwGAxq6CkXXNGWrG5DCmixvTI6Fba0yVaUU6lKZLFuxq7_eXfBfE1KsB0cW-x5G9BPVKpelnCcbMUcvD9GpGbCtd8ENEPb1_0OyX9e1YnE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2418132570</pqid></control><display><type>article</type><title>Risk factors and comorbidities associated with severe aortic stenosis: a case-control study</title><source>Elsevier ScienceDirect Journals</source><creator>Gracia Baena, J M ; Calaf Vall, I ; Zielonka, M ; Marsal Mora, J R ; Godoy, P ; Worner Diz, F</creator><creatorcontrib>Gracia Baena, J M ; Calaf Vall, I ; Zielonka, M ; Marsal Mora, J R ; Godoy, P ; Worner Diz, F</creatorcontrib><description>Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region. We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models. The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p&lt;.001), tobacco use (OR, 2.60; p&lt;.001), hypertension (OR, 2.41; p=.010) and low HDL cholesterol readings (OR, 2.20; p=.007). The comorbidities significantly associated with severe symptomatic AS were carotid stenosis (OR, 14.5; p=.017), stroke (OR, 4.14; p=.024), chronic renal failure (OR, 3.78; p&lt;.001) and low haemoglobin levels (OR, 0.76; p&lt;.001). Hypercholesterolaemia, tobacco use, arterial hypertension and low HDL cholesterol levels are the CRFs with a greater risk of severe AS. Furthermore, this disease is associated with a number of comorbidities (chronic renal failure, stroke, carotid stenosis and low haemoglobin levels), which could be markers of AS.</description><identifier>EISSN: 1578-1860</identifier><identifier>DOI: 10.1016/j.rce.2020.01.010</identifier><identifier>PMID: 32591111</identifier><language>eng ; spa</language><publisher>Spain</publisher><ispartof>Revista clínica espanõla, 2021-05, Vol.221 (5), p.249-257</ispartof><rights>Copyright © 2020 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32591111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gracia Baena, J M</creatorcontrib><creatorcontrib>Calaf Vall, I</creatorcontrib><creatorcontrib>Zielonka, M</creatorcontrib><creatorcontrib>Marsal Mora, J R</creatorcontrib><creatorcontrib>Godoy, P</creatorcontrib><creatorcontrib>Worner Diz, F</creatorcontrib><title>Risk factors and comorbidities associated with severe aortic stenosis: a case-control study</title><title>Revista clínica espanõla</title><addtitle>Rev Clin Esp</addtitle><description>Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region. We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models. The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p&lt;.001), tobacco use (OR, 2.60; p&lt;.001), hypertension (OR, 2.41; p=.010) and low HDL cholesterol readings (OR, 2.20; p=.007). The comorbidities significantly associated with severe symptomatic AS were carotid stenosis (OR, 14.5; p=.017), stroke (OR, 4.14; p=.024), chronic renal failure (OR, 3.78; p&lt;.001) and low haemoglobin levels (OR, 0.76; p&lt;.001). Hypercholesterolaemia, tobacco use, arterial hypertension and low HDL cholesterol levels are the CRFs with a greater risk of severe AS. Furthermore, this disease is associated with a number of comorbidities (chronic renal failure, stroke, carotid stenosis and low haemoglobin levels), which could be markers of AS.</description><issn>1578-1860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo1UE1LxDAUDIK46-oP8CI5emlN0jZpvcniFywIoicP5TV9xaxts-alyv57C66PgYGZYWAeYxdSpFJIfb1Ng8VUCSVSIWeII7aUhSkTWWqxYKdEWyFUkcnshC0yVVRyviV7f3H0yTuw0QfiMLbc-sGHxrUuOpwVIm8dRGz5j4sfnPAbA3LwITrLKeLoydENB26BMLF-jMH3szG1-zN23EFPeH7gFXu7v3tdPyab54en9e0m2UmlY6JACVnlHYIujCgAAYwGAxq6CkXXNGWrG5DCmixvTI6Fba0yVaUU6lKZLFuxq7_eXfBfE1KsB0cW-x5G9BPVKpelnCcbMUcvD9GpGbCtd8ENEPb1_0OyX9e1YnE</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Gracia Baena, J M</creator><creator>Calaf Vall, I</creator><creator>Zielonka, M</creator><creator>Marsal Mora, J R</creator><creator>Godoy, P</creator><creator>Worner Diz, F</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202105</creationdate><title>Risk factors and comorbidities associated with severe aortic stenosis: a case-control study</title><author>Gracia Baena, J M ; Calaf Vall, I ; Zielonka, M ; Marsal Mora, J R ; Godoy, P ; Worner Diz, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-2a20194fea65705aeaa76a7a6af9e0fbb8d6ba10c734b74e5cdc279922e682733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gracia Baena, J M</creatorcontrib><creatorcontrib>Calaf Vall, I</creatorcontrib><creatorcontrib>Zielonka, M</creatorcontrib><creatorcontrib>Marsal Mora, J R</creatorcontrib><creatorcontrib>Godoy, P</creatorcontrib><creatorcontrib>Worner Diz, F</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista clínica espanõla</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gracia Baena, J M</au><au>Calaf Vall, I</au><au>Zielonka, M</au><au>Marsal Mora, J R</au><au>Godoy, P</au><au>Worner Diz, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors and comorbidities associated with severe aortic stenosis: a case-control study</atitle><jtitle>Revista clínica espanõla</jtitle><addtitle>Rev Clin Esp</addtitle><date>2021-05</date><risdate>2021</risdate><volume>221</volume><issue>5</issue><spage>249</spage><epage>257</epage><pages>249-257</pages><eissn>1578-1860</eissn><abstract>Aortic stricture (AS) is one of the most prevalent cardiovascular diseases in individuals 65 years of age or older. A number of epidemiological studies have suggested that certain cardiovascular risk factors (CRFs) and comorbidities could be associated with AS. The aim of this study was to evaluate the association between CRFs and comorbidities and severe symptomatic AS in individuals 65 years of age or older in a Spanish healthcare region. We conducted an epidemiological case-control study from a single primary care centre. We collected information on exposure to CRFs and comorbidities and determined their association with AS, employing adjusted odds ratios (OR) and multiple logistic regression models. The study included 102 cases (mean age, 77.6 years) and 221 controls (mean age, 75.5 years). The CRFs significantly associated with severe symptomatic AS were hypercholesterolaemia (OR, 2.67; p&lt;.001), tobacco use (OR, 2.60; p&lt;.001), hypertension (OR, 2.41; p=.010) and low HDL cholesterol readings (OR, 2.20; p=.007). The comorbidities significantly associated with severe symptomatic AS were carotid stenosis (OR, 14.5; p=.017), stroke (OR, 4.14; p=.024), chronic renal failure (OR, 3.78; p&lt;.001) and low haemoglobin levels (OR, 0.76; p&lt;.001). Hypercholesterolaemia, tobacco use, arterial hypertension and low HDL cholesterol levels are the CRFs with a greater risk of severe AS. Furthermore, this disease is associated with a number of comorbidities (chronic renal failure, stroke, carotid stenosis and low haemoglobin levels), which could be markers of AS.</abstract><cop>Spain</cop><pmid>32591111</pmid><doi>10.1016/j.rce.2020.01.010</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier EISSN: 1578-1860
ispartof Revista clínica espanõla, 2021-05, Vol.221 (5), p.249-257
issn 1578-1860
language eng ; spa
recordid cdi_proquest_miscellaneous_2418132570
source Elsevier ScienceDirect Journals
title Risk factors and comorbidities associated with severe aortic stenosis: a case-control study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T02%3A54%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20factors%20and%20comorbidities%20associated%20with%20severe%20aortic%20stenosis:%20a%20case-control%20study&rft.jtitle=Revista%20cl%C3%ADnica%20espan%C3%B5la&rft.au=Gracia%20Baena,%20J%20M&rft.date=2021-05&rft.volume=221&rft.issue=5&rft.spage=249&rft.epage=257&rft.pages=249-257&rft.eissn=1578-1860&rft_id=info:doi/10.1016/j.rce.2020.01.010&rft_dat=%3Cproquest_pubme%3E2418132570%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2418132570&rft_id=info:pmid/32591111&rfr_iscdi=true