iRhom2 Promotes Hepatic Steatosis by Activating MAP3K7‐Dependent Pathway

Background and Aims Nonalcoholic fatty liver disease (NAFLD) has been widely recognized as a precursor to metabolic complications. Elevated inflammation levels are predictive of NAFLD‐associated metabolic disorder. Inactive rhomboid‐like protein 2 (iRhom2) is regarded as a key regulator in inflammat...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-04, Vol.73 (4), p.1346-1364
Hauptverfasser:	Xu, Minxuan, Ge, Chenxu, Zhu, Liancai, Qin, Yuting, Du, Chengjiang, Lou, Deshuai, Li, Qiang, Hu, Linfeng, Sun, Yan, Dai, Xianling, Xiong, Mingxin, Long, Tingting, Zhan, Jianxia, Kuang, Qin, Li, Huanhuan, Yang, Qiufeng, Huang, Ping, Teng, Xuepeng, Feng, Jing, Wu, Yekuan, Dong, Wei, Wang, Bochu, Tan, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic AKT protein Animals Bone marrow transplantation Carrier Proteins - biosynthesis Carrier Proteins - metabolism Cell activation Diet, High-Fat - adverse effects Disease Models, Animal Disease Progression Dyslipidemia Fatty liver Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - physiopathology Glycogen Glycogen synthase kinase 3 Hepatology High fat diet Inflammation Inflammation - metabolism Inflammation - physiopathology Insulin Insulin receptor substrate 1 Insulin resistance Insulin Resistance - physiology Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - metabolism JNK protein Kinases Liver - metabolism Liver - physiopathology Liver diseases Macrophages Macrophages - metabolism MAP Kinase Kinase Kinases - metabolism Metabolic disorders Metabolism Mice Mice, Inbred C57BL Mice, Knockout Myeloid cells Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - physiopathology Phosphorylation Protein kinase Signal Transduction Steatosis Therapeutic targets
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