Zebrafish model of posttraumatic epilepsy

Objective Posttraumatic epilepsy (PTE) is defined as recurrent and unprovoked seizures occurring >1 week after traumatic brain injury (TBI). Animal studies of PTE are lengthy and expensive. In this study, we developed a cost‐effective PTE animal model using zebrafish to bridge the gap between in...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2020-08, Vol.61 (8), p.1774-1785
Hauptverfasser:	Cho, Sung‐Joon, Park, Eugene, Telliyan, Tamar, Baker, Andrew, Reid, Aylin Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Behavior, Animal Blood-brain barrier Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Brain - physiopathology Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - physiopathology Convulsants - pharmacology Convulsions & seizures Danio rerio Disease Models, Animal Epilepsy Epilepsy, Post-Traumatic - etiology Epilepsy, Post-Traumatic - metabolism Epilepsy, Post-Traumatic - physiopathology HMGB1 protein HMGB1 Protein - metabolism Pentylenetetrazole Pentylenetetrazole - pharmacology posttraumatic epilepsy Proto-Oncogene Proteins c-akt - metabolism seizure Seizures tau Proteins - metabolism Traumatic brain injury Ultrasonic Waves Ultrasound Zebrafish
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