Inhibition of miR-497-3p Downregulates the Expression of Procalcitonin and Ameliorates Bacterial Pneumonia in Mice

Pneumonia is usually caused by a wide variety of pathogen infection. The underlying mechanism contributing to pneumonia remains elusive. Here, the role of microRNA-497-3p (miR-497-3p) was explored in bacterial pneumonia. The expression levels of miR-497-3p and procalcitonin (PCT) in patient serum we...

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Veröffentlicht in:	Inflammation 2020-12, Vol.43 (6), p.2119-2127
Hauptverfasser:	Wang, Wenlong, Zhu, Yitang, Yin, Linlin, Deng, Yaoyao, Chu, Guoxian, Liu, Supin
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Bacteria Biomedical and Life Sciences Biomedicine C-reactive protein Calcitonin Gene-Related Peptide Cytokines - metabolism Down-Regulation Enzyme-linked immunosorbent assay Gene Expression Profiling Humans Immunology Infections Inflammation Interleukin 6 Internal Medicine Mice Mice, Inbred C57BL MicroRNAs - antagonists & inhibitors miRNA Original Article Pathology Pharmacology/Toxicology Pneumonia Pneumonia, Bacterial - metabolism Pneumonia, Bacterial - therapy Polymerase chain reaction Procalcitonin Procalcitonin - biosynthesis Rheumatology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Up-Regulation
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