Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex
Objectives The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated. Methods The C57 observer was placed in the cage next to the...
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| Veröffentlicht in: | Psychopharmacology 2020-10, Vol.237 (10), p.3067-3093 |
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| creator | Yang, Jiuyong Sun, Jinyan Lu, Yanjun An, Tingting Lu, Wei Wang, Jin-Hui |
| description | Objectives
The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated.
Methods
The C57 observer was placed in the cage next to the CD1 mouse and suffered psychological stress by watching the CD1 attacking another C57 mouse. After 5 days of psychological stress, the degree of fear memory and anxiety of mice were measured by social interaction test and elevated plus maze (EPM). The prefrontal cortex was extracted and mRNA and microRNA profiles were analyzed by high-throughput sequencing.
Results
In susceptible mice versus resilient mice, the downregulation of genes involved in serotonergic synapse may be related to the susceptibility to psychological stress. The imbalanced regulation of genes involved in VEGF, p53, chemokine, Ras, sphingolipid, GnRH, MAPK, and NOD-like receptor signaling pathways may be related to the susceptibility to psychological stress. Compared with control mice, susceptible mice and resilient mice have changed genes involved in serotonergic synapse, neuroactive ligand-receptor interaction, axon guidance, calcium, cAMP, GnRH, estrogen, PI3K-Akt, MAPK, Rap1, and Ras signaling pathways, these changes may be related to psychological stress processing. The sequencing results of mRNAs and microRNAs were verified by qRT-PCR and dual-luciferase reporter assay.
Conclusions
The downregulation of genes involved in serotonergic synapse and imbalance of signaling pathways in the prefrontal cortex may be related to susceptibility to psychological stress. |
| doi_str_mv | 10.1007/s00213-020-05593-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2418123459</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A636978187</galeid><sourcerecordid>A636978187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-f7ddd274839e7bbf24e847d9c64525b72d3a4ba3176f6f1c531a93d9d2a5ffd03</originalsourceid><addsrcrecordid>eNp9UstuEzEUtRCIhsAPsECW2LCZ4te8llHFS6pAqmBteew7iauZcbA9Jfmm_mRvmpQKhLAX1rXPuY_jQ8hrzs45Y_X7xJjgsmCCFawsW1nsnpAFV1IUgtXiKVkwJmUhedmckRcpXTNcqlHPyZkUZctb2SzI7RXc-OTDRHOg27S3m7DdmDgaG4aw3tPx6uuKmsnR0dsYDsE2ht4PkKiJQE1KwXqTwdFfPm9oyhFSomlOFrbZd37weX_Px3sMYLJA_eRmi4xuf6qIlbw1wwPbYzMbwELQxzBlfLAhZti9JM96MyR4dTqX5MfHD98vPheX3z59uVhdFlYpkYu-ds6JWjWyhbrreqGgUbVrbaVKUXa1cNKozkheV33Vc1tKblrpWidM2feOySV5d8yLo_6cIWU9epxnGMwEYU5aKN5wIRVKviRv_4JehzlO2J0WZaWqtilV9YhamwG0n_qQo7GHpHpVyaqtG97UiDr_Bwq3AxQ_THCQ_U-COBLwZ1JCtfQ2-tHEveZMHxyijw7R6BB97xC9Q9KbU8dzN4L7TXmwBALkEZDwaVpDfBzpP2nvAN7Uygs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2564698546</pqid></control><display><type>article</type><title>Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Yang, Jiuyong ; Sun, Jinyan ; Lu, Yanjun ; An, Tingting ; Lu, Wei ; Wang, Jin-Hui</creator><creatorcontrib>Yang, Jiuyong ; Sun, Jinyan ; Lu, Yanjun ; An, Tingting ; Lu, Wei ; Wang, Jin-Hui</creatorcontrib><description>Objectives
The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated.
Methods
The C57 observer was placed in the cage next to the CD1 mouse and suffered psychological stress by watching the CD1 attacking another C57 mouse. After 5 days of psychological stress, the degree of fear memory and anxiety of mice were measured by social interaction test and elevated plus maze (EPM). The prefrontal cortex was extracted and mRNA and microRNA profiles were analyzed by high-throughput sequencing.
Results
In susceptible mice versus resilient mice, the downregulation of genes involved in serotonergic synapse may be related to the susceptibility to psychological stress. The imbalanced regulation of genes involved in VEGF, p53, chemokine, Ras, sphingolipid, GnRH, MAPK, and NOD-like receptor signaling pathways may be related to the susceptibility to psychological stress. Compared with control mice, susceptible mice and resilient mice have changed genes involved in serotonergic synapse, neuroactive ligand-receptor interaction, axon guidance, calcium, cAMP, GnRH, estrogen, PI3K-Akt, MAPK, Rap1, and Ras signaling pathways, these changes may be related to psychological stress processing. The sequencing results of mRNAs and microRNAs were verified by qRT-PCR and dual-luciferase reporter assay.
Conclusions
The downregulation of genes involved in serotonergic synapse and imbalance of signaling pathways in the prefrontal cortex may be related to susceptibility to psychological stress.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-020-05593-x</identifier><identifier>PMID: 32591938</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Analysis ; Animals ; Anxiety ; Anxiety - genetics ; Anxiety - metabolism ; Anxiety - psychology ; Axon guidance ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Chemokines ; Fear - physiology ; Fear - psychology ; Gene regulation ; Gonadotropin-releasing hormone ; Male ; MAP kinase ; Memory - physiology ; Messenger RNA ; Mice ; Mice, Inbred C57BL ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; mRNA ; Nervous system diseases ; Neurological diseases ; Neurosciences ; Next-generation sequencing ; Original Investigation ; p53 Protein ; Pharmacology/Toxicology ; Prefrontal cortex ; Prefrontal Cortex - metabolism ; Psychiatry ; Psychopharmacology ; Rap1 protein ; Resilience, Psychological ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal transduction ; Social aspects ; Species Specificity ; Stress (Psychology) ; Stress, Psychological - genetics ; Stress, Psychological - metabolism ; Stress, Psychological - psychology ; Susceptibility ; Synapses ; Tumor proteins ; Vascular endothelial growth factor</subject><ispartof>Psychopharmacology, 2020-10, Vol.237 (10), p.3067-3093</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-f7ddd274839e7bbf24e847d9c64525b72d3a4ba3176f6f1c531a93d9d2a5ffd03</citedby><cites>FETCH-LOGICAL-c442t-f7ddd274839e7bbf24e847d9c64525b72d3a4ba3176f6f1c531a93d9d2a5ffd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-020-05593-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-020-05593-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32591938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Jiuyong</creatorcontrib><creatorcontrib>Sun, Jinyan</creatorcontrib><creatorcontrib>Lu, Yanjun</creatorcontrib><creatorcontrib>An, Tingting</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Wang, Jin-Hui</creatorcontrib><title>Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Objectives
The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated.
Methods
The C57 observer was placed in the cage next to the CD1 mouse and suffered psychological stress by watching the CD1 attacking another C57 mouse. After 5 days of psychological stress, the degree of fear memory and anxiety of mice were measured by social interaction test and elevated plus maze (EPM). The prefrontal cortex was extracted and mRNA and microRNA profiles were analyzed by high-throughput sequencing.
Results
In susceptible mice versus resilient mice, the downregulation of genes involved in serotonergic synapse may be related to the susceptibility to psychological stress. The imbalanced regulation of genes involved in VEGF, p53, chemokine, Ras, sphingolipid, GnRH, MAPK, and NOD-like receptor signaling pathways may be related to the susceptibility to psychological stress. Compared with control mice, susceptible mice and resilient mice have changed genes involved in serotonergic synapse, neuroactive ligand-receptor interaction, axon guidance, calcium, cAMP, GnRH, estrogen, PI3K-Akt, MAPK, Rap1, and Ras signaling pathways, these changes may be related to psychological stress processing. The sequencing results of mRNAs and microRNAs were verified by qRT-PCR and dual-luciferase reporter assay.
Conclusions
The downregulation of genes involved in serotonergic synapse and imbalance of signaling pathways in the prefrontal cortex may be related to susceptibility to psychological stress.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Analysis</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - psychology</subject><subject>Axon guidance</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Chemokines</subject><subject>Fear - physiology</subject><subject>Fear - psychology</subject><subject>Gene regulation</subject><subject>Gonadotropin-releasing hormone</subject><subject>Male</subject><subject>MAP kinase</subject><subject>Memory - physiology</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>mRNA</subject><subject>Nervous system diseases</subject><subject>Neurological diseases</subject><subject>Neurosciences</subject><subject>Next-generation sequencing</subject><subject>Original Investigation</subject><subject>p53 Protein</subject><subject>Pharmacology/Toxicology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rap1 protein</subject><subject>Resilience, Psychological</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal transduction</subject><subject>Social aspects</subject><subject>Species Specificity</subject><subject>Stress (Psychology)</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - psychology</subject><subject>Susceptibility</subject><subject>Synapses</subject><subject>Tumor proteins</subject><subject>Vascular endothelial growth factor</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UstuEzEUtRCIhsAPsECW2LCZ4te8llHFS6pAqmBteew7iauZcbA9Jfmm_mRvmpQKhLAX1rXPuY_jQ8hrzs45Y_X7xJjgsmCCFawsW1nsnpAFV1IUgtXiKVkwJmUhedmckRcpXTNcqlHPyZkUZctb2SzI7RXc-OTDRHOg27S3m7DdmDgaG4aw3tPx6uuKmsnR0dsYDsE2ht4PkKiJQE1KwXqTwdFfPm9oyhFSomlOFrbZd37weX_Px3sMYLJA_eRmi4xuf6qIlbw1wwPbYzMbwELQxzBlfLAhZti9JM96MyR4dTqX5MfHD98vPheX3z59uVhdFlYpkYu-ds6JWjWyhbrreqGgUbVrbaVKUXa1cNKozkheV33Vc1tKblrpWidM2feOySV5d8yLo_6cIWU9epxnGMwEYU5aKN5wIRVKviRv_4JehzlO2J0WZaWqtilV9YhamwG0n_qQo7GHpHpVyaqtG97UiDr_Bwq3AxQ_THCQ_U-COBLwZ1JCtfQ2-tHEveZMHxyijw7R6BB97xC9Q9KbU8dzN4L7TXmwBALkEZDwaVpDfBzpP2nvAN7Uygs</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Yang, Jiuyong</creator><creator>Sun, Jinyan</creator><creator>Lu, Yanjun</creator><creator>An, Tingting</creator><creator>Lu, Wei</creator><creator>Wang, Jin-Hui</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex</title><author>Yang, Jiuyong ; Sun, Jinyan ; Lu, Yanjun ; An, Tingting ; Lu, Wei ; Wang, Jin-Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-f7ddd274839e7bbf24e847d9c64525b72d3a4ba3176f6f1c531a93d9d2a5ffd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Analysis</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - genetics</topic><topic>Anxiety - metabolism</topic><topic>Anxiety - psychology</topic><topic>Axon guidance</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Chemokines</topic><topic>Fear - physiology</topic><topic>Fear - psychology</topic><topic>Gene regulation</topic><topic>Gonadotropin-releasing hormone</topic><topic>Male</topic><topic>MAP kinase</topic><topic>Memory - physiology</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>mRNA</topic><topic>Nervous system diseases</topic><topic>Neurological diseases</topic><topic>Neurosciences</topic><topic>Next-generation sequencing</topic><topic>Original Investigation</topic><topic>p53 Protein</topic><topic>Pharmacology/Toxicology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rap1 protein</topic><topic>Resilience, Psychological</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal transduction</topic><topic>Social aspects</topic><topic>Species Specificity</topic><topic>Stress (Psychology)</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - psychology</topic><topic>Susceptibility</topic><topic>Synapses</topic><topic>Tumor proteins</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Jiuyong</creatorcontrib><creatorcontrib>Sun, Jinyan</creatorcontrib><creatorcontrib>Lu, Yanjun</creatorcontrib><creatorcontrib>An, Tingting</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Wang, Jin-Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Jiuyong</au><au>Sun, Jinyan</au><au>Lu, Yanjun</au><au>An, Tingting</au><au>Lu, Wei</au><au>Wang, Jin-Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>237</volume><issue>10</issue><spage>3067</spage><epage>3093</epage><pages>3067-3093</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Objectives
The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated.
Methods
The C57 observer was placed in the cage next to the CD1 mouse and suffered psychological stress by watching the CD1 attacking another C57 mouse. After 5 days of psychological stress, the degree of fear memory and anxiety of mice were measured by social interaction test and elevated plus maze (EPM). The prefrontal cortex was extracted and mRNA and microRNA profiles were analyzed by high-throughput sequencing.
Results
In susceptible mice versus resilient mice, the downregulation of genes involved in serotonergic synapse may be related to the susceptibility to psychological stress. The imbalanced regulation of genes involved in VEGF, p53, chemokine, Ras, sphingolipid, GnRH, MAPK, and NOD-like receptor signaling pathways may be related to the susceptibility to psychological stress. Compared with control mice, susceptible mice and resilient mice have changed genes involved in serotonergic synapse, neuroactive ligand-receptor interaction, axon guidance, calcium, cAMP, GnRH, estrogen, PI3K-Akt, MAPK, Rap1, and Ras signaling pathways, these changes may be related to psychological stress processing. The sequencing results of mRNAs and microRNAs were verified by qRT-PCR and dual-luciferase reporter assay.
Conclusions
The downregulation of genes involved in serotonergic synapse and imbalance of signaling pathways in the prefrontal cortex may be related to susceptibility to psychological stress.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32591938</pmid><doi>10.1007/s00213-020-05593-x</doi><tpages>27</tpages></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Analysis Animals Anxiety Anxiety - genetics Anxiety - metabolism Anxiety - psychology Axon guidance Biomedical and Life Sciences Biomedicine Calcium Chemokines Fear - physiology Fear - psychology Gene regulation Gonadotropin-releasing hormone Male MAP kinase Memory - physiology Messenger RNA Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Nervous system diseases Neurological diseases Neurosciences Next-generation sequencing Original Investigation p53 Protein Pharmacology/Toxicology Prefrontal cortex Prefrontal Cortex - metabolism Psychiatry Psychopharmacology Rap1 protein Resilience, Psychological RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Social aspects Species Specificity Stress (Psychology) Stress, Psychological - genetics Stress, Psychological - metabolism Stress, Psychological - psychology Susceptibility Synapses Tumor proteins Vascular endothelial growth factor |
| title | Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex |
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