Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT

Background MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed with a target tissue in mind, delivery is rarely assessed due to a lack of translat...

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Veröffentlicht in:	Stem cell research & therapy 2020-06, Vol.11 (1), p.1-256, Article 256
Hauptverfasser:	Patrick, P. Stephen, Kolluri, Krishna K., Zaw Thin, May, Edwards, Adam, Sage, Elizabeth K., Sanderson, Tom, Weil, Benjamin D., Dickson, John C., Lythgoe, Mark F., Lowdell, Mark, Janes, Sam M., Kalber, Tammy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	89Zr-oxine Adenocarcinoma Apoptosis Autoradiography Bioluminescence Cancer Care and treatment Cell & Tissue Engineering Cell Biology Cell culture Cell proliferation Cell therapy Cell tracking Computed tomography Cord-derived MSCs CT imaging Dosimetry Flow cytometry Genetically modified organisms Health aspects Injection Intravenous administration Labeling Life Sciences & Biomedicine Lung cancer Medicine, Research & Experimental Metastases Metastasis PET-CT Phenotypes Plasmids Research & Experimental Medicine Science & Technology TRAIL Umbilical cord
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