A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy
Photodynamic therapy is a new technology for disease diagnosis and treatment in modern medical clinics. The main advantages of photodynamic therapy are low toxicity and side effects, a wide range of applications, no drug resistance, and no obvious trauma in the treatment process. However, to achieve...
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| Veröffentlicht in: | Biomedical materials (Bristol) 2021-07, Vol.16 (4), p.45003 |
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| container_title | Biomedical materials (Bristol) |
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| creator | Pan, Qi Li, Kaixuan Cheng, Xiaoyi Chen, Lin Yu, Qi Fan, HengXin Zheng, Liang Yang, Zihua Ni, Feng |
| description | Photodynamic therapy is a new technology for disease diagnosis and treatment in modern medical clinics. The main advantages of photodynamic therapy are low toxicity and side effects, a wide range of applications, no drug resistance, and no obvious trauma in the treatment process. However, to achieve effective photodynamic therapy, new photosensitizer carriers need to be constructed, which can selectively deliver photosensitizers into tumor tissues. In this work, a photoactivatable antibody-Chlorin e6 conjugate with a dual-function to target tumor tissue and realize cancer photodynamic therapy is constructed. Both
and
experiments indicate that the antibody-Chlorin e6 conjugate has the ability to target tumors rapidly and efficiently, and has the ability to generate reactive oxygen species and kill tumor cells. Overall, this photoactivable antibody-Chlorin e6 conjugate may provide a promising strategy to address the current challenges of cancer photodynamic therapy. |
| doi_str_mv | 10.1088/1748-605X/ab9f57 |
| format | Article |
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and
experiments indicate that the antibody-Chlorin e6 conjugate has the ability to target tumors rapidly and efficiently, and has the ability to generate reactive oxygen species and kill tumor cells. Overall, this photoactivable antibody-Chlorin e6 conjugate may provide a promising strategy to address the current challenges of cancer photodynamic therapy.</description><identifier>ISSN: 1748-6041</identifier><identifier>EISSN: 1748-605X</identifier><identifier>DOI: 10.1088/1748-605X/ab9f57</identifier><identifier>PMID: 32584266</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Apoptosis - drug effects ; B7-H1 Antigen - metabolism ; Cell Line ; Chlorophyllides - chemistry ; Chlorophyllides - pharmacokinetics ; Female ; HCT116 Cells ; Humans ; Immunoconjugates - chemistry ; Immunoconjugates - pharmacokinetics ; Mice ; Mice, Nude ; Optical Imaging ; Photochemotherapy - methods ; Singlet Oxygen - metabolism ; Singlet Oxygen - pharmacology</subject><ispartof>Biomedical materials (Bristol), 2021-07, Vol.16 (4), p.45003</ispartof><rights>Creative Commons Attribution license.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-d96a48b39e145058aa868fe99618942d0034185cdfd698fb5f75040b46bc03a13</citedby><cites>FETCH-LOGICAL-c341t-d96a48b39e145058aa868fe99618942d0034185cdfd698fb5f75040b46bc03a13</cites><orcidid>0000-0001-8542-0925</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32584266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Qi</creatorcontrib><creatorcontrib>Li, Kaixuan</creatorcontrib><creatorcontrib>Cheng, Xiaoyi</creatorcontrib><creatorcontrib>Chen, Lin</creatorcontrib><creatorcontrib>Yu, Qi</creatorcontrib><creatorcontrib>Fan, HengXin</creatorcontrib><creatorcontrib>Zheng, Liang</creatorcontrib><creatorcontrib>Yang, Zihua</creatorcontrib><creatorcontrib>Ni, Feng</creatorcontrib><title>A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy</title><title>Biomedical materials (Bristol)</title><addtitle>Biomed Mater</addtitle><description>Photodynamic therapy is a new technology for disease diagnosis and treatment in modern medical clinics. The main advantages of photodynamic therapy are low toxicity and side effects, a wide range of applications, no drug resistance, and no obvious trauma in the treatment process. However, to achieve effective photodynamic therapy, new photosensitizer carriers need to be constructed, which can selectively deliver photosensitizers into tumor tissues. In this work, a photoactivatable antibody-Chlorin e6 conjugate with a dual-function to target tumor tissue and realize cancer photodynamic therapy is constructed. Both
and
experiments indicate that the antibody-Chlorin e6 conjugate has the ability to target tumors rapidly and efficiently, and has the ability to generate reactive oxygen species and kill tumor cells. Overall, this photoactivable antibody-Chlorin e6 conjugate may provide a promising strategy to address the current challenges of cancer photodynamic therapy.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Cell Line</subject><subject>Chlorophyllides - chemistry</subject><subject>Chlorophyllides - pharmacokinetics</subject><subject>Female</subject><subject>HCT116 Cells</subject><subject>Humans</subject><subject>Immunoconjugates - chemistry</subject><subject>Immunoconjugates - pharmacokinetics</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Optical Imaging</subject><subject>Photochemotherapy - methods</subject><subject>Singlet Oxygen - metabolism</subject><subject>Singlet Oxygen - pharmacology</subject><issn>1748-6041</issn><issn>1748-605X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LwzAYh4MoTqd3T5Kjl7qk-WhyHMMvGHhR8BbSNu062mQmqVjwj7d1c5ckhOf3e18eAG4wusdIiAXOqEg4Yh8LncuKZSfg4vh1enxTPAOXIWwRYpIReQ5mJGWCppxfgJ8l3G1cdLqIzZeOOm8N1DY2uSuHZLVpnW8sNBwWzm77WkcDjR2hxtYwjEdrInTfQ20s3HlX9mOLs7ByHsa-cz6J2tcmTvTflHKwumsKGDfG691wBc4q3QZzfbjn4P3x4W31nKxfn15Wy3VSEIpjUkquqciJNJgyxITWgovKSMmxkDQtERoxwYqyKrkUVc6qjCGKcsrzAhGNyRzc7XvHHT97E6LqmlCYttXWuD6olOKMSMJQOqJojxbeheBNpXa-6bQfFEZqcq4mqWoSrPbOx8jtob3PO1MeA_-SyS-fQIAk</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Pan, Qi</creator><creator>Li, Kaixuan</creator><creator>Cheng, Xiaoyi</creator><creator>Chen, Lin</creator><creator>Yu, Qi</creator><creator>Fan, HengXin</creator><creator>Zheng, Liang</creator><creator>Yang, Zihua</creator><creator>Ni, Feng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8542-0925</orcidid></search><sort><creationdate>20210701</creationdate><title>A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy</title><author>Pan, Qi ; Li, Kaixuan ; Cheng, Xiaoyi ; Chen, Lin ; Yu, Qi ; Fan, HengXin ; Zheng, Liang ; Yang, Zihua ; Ni, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-d96a48b39e145058aa868fe99618942d0034185cdfd698fb5f75040b46bc03a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>B7-H1 Antigen - metabolism</topic><topic>Cell Line</topic><topic>Chlorophyllides - chemistry</topic><topic>Chlorophyllides - pharmacokinetics</topic><topic>Female</topic><topic>HCT116 Cells</topic><topic>Humans</topic><topic>Immunoconjugates - chemistry</topic><topic>Immunoconjugates - pharmacokinetics</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Optical Imaging</topic><topic>Photochemotherapy - methods</topic><topic>Singlet Oxygen - metabolism</topic><topic>Singlet Oxygen - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Qi</creatorcontrib><creatorcontrib>Li, Kaixuan</creatorcontrib><creatorcontrib>Cheng, Xiaoyi</creatorcontrib><creatorcontrib>Chen, Lin</creatorcontrib><creatorcontrib>Yu, Qi</creatorcontrib><creatorcontrib>Fan, HengXin</creatorcontrib><creatorcontrib>Zheng, Liang</creatorcontrib><creatorcontrib>Yang, Zihua</creatorcontrib><creatorcontrib>Ni, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical materials (Bristol)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Qi</au><au>Li, Kaixuan</au><au>Cheng, Xiaoyi</au><au>Chen, Lin</au><au>Yu, Qi</au><au>Fan, HengXin</au><au>Zheng, Liang</au><au>Yang, Zihua</au><au>Ni, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy</atitle><jtitle>Biomedical materials (Bristol)</jtitle><addtitle>Biomed Mater</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>45003</spage><pages>45003-</pages><issn>1748-6041</issn><eissn>1748-605X</eissn><abstract>Photodynamic therapy is a new technology for disease diagnosis and treatment in modern medical clinics. The main advantages of photodynamic therapy are low toxicity and side effects, a wide range of applications, no drug resistance, and no obvious trauma in the treatment process. However, to achieve effective photodynamic therapy, new photosensitizer carriers need to be constructed, which can selectively deliver photosensitizers into tumor tissues. In this work, a photoactivatable antibody-Chlorin e6 conjugate with a dual-function to target tumor tissue and realize cancer photodynamic therapy is constructed. Both
and
experiments indicate that the antibody-Chlorin e6 conjugate has the ability to target tumors rapidly and efficiently, and has the ability to generate reactive oxygen species and kill tumor cells. Overall, this photoactivable antibody-Chlorin e6 conjugate may provide a promising strategy to address the current challenges of cancer photodynamic therapy.</abstract><cop>England</cop><pmid>32584266</pmid><doi>10.1088/1748-605X/ab9f57</doi><orcidid>https://orcid.org/0000-0001-8542-0925</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Animals Apoptosis - drug effects B7-H1 Antigen - metabolism Cell Line Chlorophyllides - chemistry Chlorophyllides - pharmacokinetics Female HCT116 Cells Humans Immunoconjugates - chemistry Immunoconjugates - pharmacokinetics Mice Mice, Nude Optical Imaging Photochemotherapy - methods Singlet Oxygen - metabolism Singlet Oxygen - pharmacology |
| title | A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy |
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