MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases
Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features...
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| Veröffentlicht in: | Frontiers in molecular neuroscience 2020-06, Vol.13, p.90-90 |
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| creator | Fan, Weihao Liang, Chunmei Ou, Mingqian Zou, Ting Sun, Furong Zhou, Haihong Cui, Lili |
| description | Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases. |
| doi_str_mv | 10.3389/fnmol.2020.00090 |
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The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases.</description><identifier>ISSN: 1662-5099</identifier><identifier>EISSN: 1662-5099</identifier><identifier>DOI: 10.3389/fnmol.2020.00090</identifier><identifier>PMID: 32581706</identifier><language>eng</language><publisher>Lausanne: Frontiers Research Foundation</publisher><subject>Apoptosis ; biomarker ; Cerebrovascular disease ; Cytokines ; Gene expression ; Inflammation ; Kinases ; microRNA-146a ; MicroRNAs ; miRNA ; Nervous system ; Neurodegenerative diseases ; neuroinflammation ; Neurological diseases ; Neuroscience ; Polymorphism ; Roles ; single-nucleotide polymorphisms ; Stroke ; Therapeutic applications ; Tumor necrosis factor-TNF ; Viral infections</subject><ispartof>Frontiers in molecular neuroscience, 2020-06, Vol.13, p.90-90</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020 Fan, Liang, Ou, Zou, Sun, Zhou and Cui. 2020 Fan, Liang, Ou, Zou, Sun, Zhou and Cui</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-12acd55eecc383540f5d8ed48274ea9dde251268d0d2721fa1430f438f4473633</citedby><cites>FETCH-LOGICAL-c467t-12acd55eecc383540f5d8ed48274ea9dde251268d0d2721fa1430f438f4473633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Fan, Weihao</creatorcontrib><creatorcontrib>Liang, Chunmei</creatorcontrib><creatorcontrib>Ou, Mingqian</creatorcontrib><creatorcontrib>Zou, Ting</creatorcontrib><creatorcontrib>Sun, Furong</creatorcontrib><creatorcontrib>Zhou, Haihong</creatorcontrib><creatorcontrib>Cui, Lili</creatorcontrib><title>MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases</title><title>Frontiers in molecular neuroscience</title><description>Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases.</description><subject>Apoptosis</subject><subject>biomarker</subject><subject>Cerebrovascular disease</subject><subject>Cytokines</subject><subject>Gene expression</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>microRNA-146a</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Nervous system</subject><subject>Neurodegenerative diseases</subject><subject>neuroinflammation</subject><subject>Neurological diseases</subject><subject>Neuroscience</subject><subject>Polymorphism</subject><subject>Roles</subject><subject>single-nucleotide polymorphisms</subject><subject>Stroke</subject><subject>Therapeutic applications</subject><subject>Tumor necrosis factor-TNF</subject><subject>Viral infections</subject><issn>1662-5099</issn><issn>1662-5099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNpdkktv1DAURiMEoqWwZ2mJDZsMfsWxN0hVeY1UChoNYmndsW9Sj5K42AlS_z2emQpRVr62j4-u7a-qXjO6EkKbd900xmHFKacrSqmhT6pzphSvG2rM03_qs-pFzntKFVeNeF6dCd5o1lJ1Xs1fg0txc3NZM6mArDMB8jN4rDcI7jZMPbnBJcUwdQOMI8wx3ZMN9stwKAlMnnyPM05zgIFsE8I8lgnZQupxJmE6nR5iH1wBPoSMkDG_rJ51MGR89TBeVD8-fdxefamvv31eX11e106qdq4ZB-ebBtE5oUUjadd4jV5q3koE4z3yhnGlPfW85awDJgXtpNCdlK1QQlxU65PXR9jbuxRGSPc2QrDHhZh6C2kObkBrNO-09-A6DsVidq5lXjS7FqhRjXTF9f7kult2I3pXrplgeCR9vDOFW9vH37blhmmli-DtgyDFXwvm2Y4hOxwGmDAu2XLJWmEoM4e-3_yH7uOSpvJUhaKmVZpRUyh6osoH5pyw-9sMo_YQD3uMhz3Ewx7jIf4AoqKtjg</recordid><startdate>20200605</startdate><enddate>20200605</enddate><creator>Fan, Weihao</creator><creator>Liang, Chunmei</creator><creator>Ou, Mingqian</creator><creator>Zou, Ting</creator><creator>Sun, Furong</creator><creator>Zhou, Haihong</creator><creator>Cui, Lili</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200605</creationdate><title>MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases</title><author>Fan, Weihao ; Liang, Chunmei ; Ou, Mingqian ; Zou, Ting ; Sun, Furong ; Zhou, Haihong ; Cui, Lili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-12acd55eecc383540f5d8ed48274ea9dde251268d0d2721fa1430f438f4473633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>biomarker</topic><topic>Cerebrovascular disease</topic><topic>Cytokines</topic><topic>Gene expression</topic><topic>Inflammation</topic><topic>Kinases</topic><topic>microRNA-146a</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Nervous system</topic><topic>Neurodegenerative diseases</topic><topic>neuroinflammation</topic><topic>Neurological diseases</topic><topic>Neuroscience</topic><topic>Polymorphism</topic><topic>Roles</topic><topic>single-nucleotide polymorphisms</topic><topic>Stroke</topic><topic>Therapeutic applications</topic><topic>Tumor necrosis factor-TNF</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Weihao</creatorcontrib><creatorcontrib>Liang, Chunmei</creatorcontrib><creatorcontrib>Ou, Mingqian</creatorcontrib><creatorcontrib>Zou, Ting</creatorcontrib><creatorcontrib>Sun, Furong</creatorcontrib><creatorcontrib>Zhou, Haihong</creatorcontrib><creatorcontrib>Cui, Lili</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Weihao</au><au>Liang, Chunmei</au><au>Ou, Mingqian</au><au>Zou, Ting</au><au>Sun, Furong</au><au>Zhou, Haihong</au><au>Cui, Lili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases</atitle><jtitle>Frontiers in molecular neuroscience</jtitle><date>2020-06-05</date><risdate>2020</risdate><volume>13</volume><spage>90</spage><epage>90</epage><pages>90-90</pages><issn>1662-5099</issn><eissn>1662-5099</eissn><abstract>Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. 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Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases.</abstract><cop>Lausanne</cop><pub>Frontiers Research Foundation</pub><pmid>32581706</pmid><doi>10.3389/fnmol.2020.00090</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis biomarker Cerebrovascular disease Cytokines Gene expression Inflammation Kinases microRNA-146a MicroRNAs miRNA Nervous system Neurodegenerative diseases neuroinflammation Neurological diseases Neuroscience Polymorphism Roles single-nucleotide polymorphisms Stroke Therapeutic applications Tumor necrosis factor-TNF Viral infections |
| title | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
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