Development of a plasma pseudotargeted metabolomics method based on ultra-high-performance liquid chromatography–mass spectrometry

Untargeted methods are typically used in the detection and discovery of small organic compounds in metabolomics research, and ultra-high-performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HRMS) is one of the most commonly used platforms for untargeted metabolomics. Although t...

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Veröffentlicht in:	Nature protocols 2020-08, Vol.15 (8), p.2519-2537
Hauptverfasser:	Zheng, Fujian, Zhao, Xinjie, Zeng, Zhongda, Wang, Lichao, Lv, Wangjie, Wang, Qingqing, Xu, Guowang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2196 631/45/320 Analytical Chemistry Biological Techniques Biomedical and Life Sciences Chromatography Chromatography, High Pressure Liquid Computational Biology/Bioinformatics Data processing High performance liquid chromatography Ions Life Sciences Liquid chromatography Mass Spectrometry Mass spectroscopy Metabolites Metabolomics Metabolomics - methods Methods Microarrays Monitoring Organic Chemistry Organic compounds Plasma - metabolism Protocol Quadrupoles Retention time Scientific imaging Spectroscopy Time Factors
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