Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties
Recently, silver (Ag) and copper (Cu) have been incorporated into a titanium (Ti) surface to realize their antibacterial property. This study investigated both the durability of the antibacterial effect and the surface change of the Ag- and Cu-incorporated porous titanium dioxide (TiO2) layer. Ag- a...
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| Veröffentlicht in: | Journal of functional biomaterials 2020-06, Vol.11 (2), p.44, Article 44 |
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| creator | Shimabukuro, Masaya Hiji, Akari Manaka, Tomoyo Nozaki, Kosuke Chen, Peng Ashida, Maki Tsutsumi, Yusuke Nagai, Akiko Hanawa, Takao |
| description | Recently, silver (Ag) and copper (Cu) have been incorporated into a titanium (Ti) surface to realize their antibacterial property. This study investigated both the durability of the antibacterial effect and the surface change of the Ag- and Cu-incorporated porous titanium dioxide (TiO2) layer. Ag- and Cu-incorporated TiO2 layers were formed by micro-arc oxidation (MAO) treatment using the electrolyte with Ag and Cu ions. Ag- and Cu-incorporated specimens were incubated in saline during a period of 0-28 days. The changes in both the concentrations and chemical states of the Ag and Cu were characterized using X-ray photoelectron spectroscopy (XPS). The durability of the antibacterial effects againstEscherichia coli(E. coli)were evaluated by the international organization for standardization (ISO) method. As a result, the Ag- and Cu-incorporated porous TiO2 layers were formed on a Ti surface by MAO. The chemical state of Ag changed from Ag2O to metallic Ag, whilst that of Cu did not change by incubation in saline for up to 28 days. Cu existed as a stable Cu2O compound in the TiO2 layer during the 28 days of incubation in saline. The concentrations of Ag and Cu were dramatically decreased by incubation for up to 7 days, and remained a slight amount until 28 days. The antibacterial effect of Ag-incorporated specimens diminished, and that of Cu was maintained even after incubation in saline. Our study suggests the importance of the time-transient effects of Ag and Cu on develop their antibacterial effects. |
| doi_str_mv | 10.3390/jfb11020044 |
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This study investigated both the durability of the antibacterial effect and the surface change of the Ag- and Cu-incorporated porous titanium dioxide (TiO2) layer. Ag- and Cu-incorporated TiO2 layers were formed by micro-arc oxidation (MAO) treatment using the electrolyte with Ag and Cu ions. Ag- and Cu-incorporated specimens were incubated in saline during a period of 0-28 days. The changes in both the concentrations and chemical states of the Ag and Cu were characterized using X-ray photoelectron spectroscopy (XPS). The durability of the antibacterial effects againstEscherichia coli(E. coli)were evaluated by the international organization for standardization (ISO) method. As a result, the Ag- and Cu-incorporated porous TiO2 layers were formed on a Ti surface by MAO. The chemical state of Ag changed from Ag2O to metallic Ag, whilst that of Cu did not change by incubation in saline for up to 28 days. Cu existed as a stable Cu2O compound in the TiO2 layer during the 28 days of incubation in saline. The concentrations of Ag and Cu were dramatically decreased by incubation for up to 7 days, and remained a slight amount until 28 days. The antibacterial effect of Ag-incorporated specimens diminished, and that of Cu was maintained even after incubation in saline. Our study suggests the importance of the time-transient effects of Ag and Cu on develop their antibacterial effects.</description><identifier>ISSN: 2079-4983</identifier><identifier>EISSN: 2079-4983</identifier><identifier>DOI: 10.3390/jfb11020044</identifier><identifier>PMID: 32580288</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Amine oxidase (flavin-containing) ; antibacterial ; Antibacterial activity ; Bacteria ; Biodegradation ; biofilm ; Biofilms ; coatings ; Copper ; Dilution ; Durability ; E coli ; Electrolytes ; Engineering ; Engineering, Biomedical ; implant ; Infections ; Materials Science ; Materials Science, Biomaterials ; Morphology ; Oxidation ; Photoelectron spectroscopy ; Photoelectrons ; Science & Technology ; Silver ; Software ; Standardization ; Statistical analysis ; surface modification ; Surgery ; Technology ; Titanium ; Titanium dioxide ; X ray photoelectron spectroscopy</subject><ispartof>Journal of functional biomaterials, 2020-06, Vol.11 (2), p.44, Article 44</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>16</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000551256600016</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c541t-8dda159b1e62c813841c9e652ac6a53ebf761f2ba35ac7ed6a1443b9ddb2821e3</citedby><cites>FETCH-LOGICAL-c541t-8dda159b1e62c813841c9e652ac6a53ebf761f2ba35ac7ed6a1443b9ddb2821e3</cites><orcidid>0000-0003-0007-0407 ; 0000-0002-0364-8721 ; 0000-0001-9649-2035 ; 0000-0003-1688-1749 ; 0000-0002-5131-6043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353535/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353535/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32580288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimabukuro, Masaya</creatorcontrib><creatorcontrib>Hiji, Akari</creatorcontrib><creatorcontrib>Manaka, Tomoyo</creatorcontrib><creatorcontrib>Nozaki, Kosuke</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Ashida, Maki</creatorcontrib><creatorcontrib>Tsutsumi, Yusuke</creatorcontrib><creatorcontrib>Nagai, Akiko</creatorcontrib><creatorcontrib>Hanawa, Takao</creatorcontrib><title>Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties</title><title>Journal of functional biomaterials</title><addtitle>J FUNCT BIOMATER</addtitle><addtitle>J Funct Biomater</addtitle><description>Recently, silver (Ag) and copper (Cu) have been incorporated into a titanium (Ti) surface to realize their antibacterial property. This study investigated both the durability of the antibacterial effect and the surface change of the Ag- and Cu-incorporated porous titanium dioxide (TiO2) layer. Ag- and Cu-incorporated TiO2 layers were formed by micro-arc oxidation (MAO) treatment using the electrolyte with Ag and Cu ions. Ag- and Cu-incorporated specimens were incubated in saline during a period of 0-28 days. The changes in both the concentrations and chemical states of the Ag and Cu were characterized using X-ray photoelectron spectroscopy (XPS). The durability of the antibacterial effects againstEscherichia coli(E. coli)were evaluated by the international organization for standardization (ISO) method. As a result, the Ag- and Cu-incorporated porous TiO2 layers were formed on a Ti surface by MAO. The chemical state of Ag changed from Ag2O to metallic Ag, whilst that of Cu did not change by incubation in saline for up to 28 days. Cu existed as a stable Cu2O compound in the TiO2 layer during the 28 days of incubation in saline. The concentrations of Ag and Cu were dramatically decreased by incubation for up to 7 days, and remained a slight amount until 28 days. The antibacterial effect of Ag-incorporated specimens diminished, and that of Cu was maintained even after incubation in saline. Our study suggests the importance of the time-transient effects of Ag and Cu on develop their antibacterial effects.</description><subject>Amine oxidase (flavin-containing)</subject><subject>antibacterial</subject><subject>Antibacterial activity</subject><subject>Bacteria</subject><subject>Biodegradation</subject><subject>biofilm</subject><subject>Biofilms</subject><subject>coatings</subject><subject>Copper</subject><subject>Dilution</subject><subject>Durability</subject><subject>E coli</subject><subject>Electrolytes</subject><subject>Engineering</subject><subject>Engineering, Biomedical</subject><subject>implant</subject><subject>Infections</subject><subject>Materials Science</subject><subject>Materials Science, Biomaterials</subject><subject>Morphology</subject><subject>Oxidation</subject><subject>Photoelectron spectroscopy</subject><subject>Photoelectrons</subject><subject>Science & 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Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties</title><author>Shimabukuro, Masaya ; Hiji, Akari ; Manaka, Tomoyo ; Nozaki, Kosuke ; Chen, Peng ; Ashida, Maki ; Tsutsumi, Yusuke ; Nagai, Akiko ; Hanawa, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-8dda159b1e62c813841c9e652ac6a53ebf761f2ba35ac7ed6a1443b9ddb2821e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amine oxidase (flavin-containing)</topic><topic>antibacterial</topic><topic>Antibacterial activity</topic><topic>Bacteria</topic><topic>Biodegradation</topic><topic>biofilm</topic><topic>Biofilms</topic><topic>coatings</topic><topic>Copper</topic><topic>Dilution</topic><topic>Durability</topic><topic>E coli</topic><topic>Electrolytes</topic><topic>Engineering</topic><topic>Engineering, 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functional biomaterials</jtitle><stitle>J FUNCT BIOMATER</stitle><addtitle>J Funct Biomater</addtitle><date>2020-06-22</date><risdate>2020</risdate><volume>11</volume><issue>2</issue><spage>44</spage><pages>44-</pages><artnum>44</artnum><issn>2079-4983</issn><eissn>2079-4983</eissn><abstract>Recently, silver (Ag) and copper (Cu) have been incorporated into a titanium (Ti) surface to realize their antibacterial property. This study investigated both the durability of the antibacterial effect and the surface change of the Ag- and Cu-incorporated porous titanium dioxide (TiO2) layer. Ag- and Cu-incorporated TiO2 layers were formed by micro-arc oxidation (MAO) treatment using the electrolyte with Ag and Cu ions. Ag- and Cu-incorporated specimens were incubated in saline during a period of 0-28 days. The changes in both the concentrations and chemical states of the Ag and Cu were characterized using X-ray photoelectron spectroscopy (XPS). The durability of the antibacterial effects againstEscherichia coli(E. coli)were evaluated by the international organization for standardization (ISO) method. As a result, the Ag- and Cu-incorporated porous TiO2 layers were formed on a Ti surface by MAO. The chemical state of Ag changed from Ag2O to metallic Ag, whilst that of Cu did not change by incubation in saline for up to 28 days. Cu existed as a stable Cu2O compound in the TiO2 layer during the 28 days of incubation in saline. The concentrations of Ag and Cu were dramatically decreased by incubation for up to 7 days, and remained a slight amount until 28 days. The antibacterial effect of Ag-incorporated specimens diminished, and that of Cu was maintained even after incubation in saline. Our study suggests the importance of the time-transient effects of Ag and Cu on develop their antibacterial effects.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32580288</pmid><doi>10.3390/jfb11020044</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0007-0407</orcidid><orcidid>https://orcid.org/0000-0002-0364-8721</orcidid><orcidid>https://orcid.org/0000-0001-9649-2035</orcidid><orcidid>https://orcid.org/0000-0003-1688-1749</orcidid><orcidid>https://orcid.org/0000-0002-5131-6043</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amine oxidase (flavin-containing) antibacterial Antibacterial activity Bacteria Biodegradation biofilm Biofilms coatings Copper Dilution Durability E coli Electrolytes Engineering Engineering, Biomedical implant Infections Materials Science Materials Science, Biomaterials Morphology Oxidation Photoelectron spectroscopy Photoelectrons Science & Technology Silver Software Standardization Statistical analysis surface modification Surgery Technology Titanium Titanium dioxide X ray photoelectron spectroscopy |
| title | Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties |
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