Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Drug Resistant Cancer Cells

Although lipids contribute to cancer drug resistance, it is challenging to target diverse range of lipids. Here, we show enzymatically inserting exceedingly simple synthetic lipids into membranes for increasing membrane tension and selectively inhibiting drug resistant cancer cells. The lipid, forme...

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Veröffentlicht in:Chemistry : a European journal 2020-11, Vol.26 (66), p.15116-15120
Hauptverfasser: Wang, Jiaqing, Tan, Weiyi, Li, Guanying, Wu, Difei, He, Hongjian, Xu, Jiashu, Yi, Meihui, Zhang, Ye, Aghvami, S. Ali, Fraden, Seth, Xu, Bing
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Sprache:eng
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