Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial
Purpose Evidence about the effect of maternal vitamin B 12 supplementation on offspring’s vitamin B 12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B 12 status. Methods In an ongoing cluste...
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| Veröffentlicht in: | European journal of nutrition 2021-03, Vol.60 (2), p.1031-1039 |
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| creator | Li, Shanshan Mi, Baibing Qu, Pengfei Liu, Danmeng Lei, Fangliang Wang, Duolao Zeng, Lingxia Kang, Yijun Shen, Yuan Pei, Leilei Zhu, Zhonghai Yan, Hong Liu, Xin Dang, Shaonong |
| description | Purpose
Evidence about the effect of maternal vitamin B
12
supplementation on offspring’s vitamin B
12
status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B
12
status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women |
| doi_str_mv | 10.1007/s00394-020-02309-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2416931075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2416931075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267x-103d74a059b81bd27bdbf33ac74a1aa8d8de2467f4040f1800711c2a3b5ddde33</originalsourceid><addsrcrecordid>eNp9kctOBCEQRYnRRB39AVckbty0FtCPaXdqfCUmbnRNaKCVCQ0j0Dr6FX6yaBtNXLioVIWce1PURWiPwCEBaI4iAGvLAijkYtAWqzW0RUpWFzUl1frPDM0m2o5xAZCxmmyh95MYvTQiGe-w77FwSTuRhMXPJonBOHyKpR-WVq9wHJe5D9qlCX8x6RE77f_whOKYiTEeY_1slHZS4z74AQss7RiTDjgIp_xg3rTK5i4Fb20eUzDC7qCNXtiod7_7DN1fnN-dXRU3t5fXZyc3haR1syoIMNWUAqq2m5NO0aZTXc-YkPmRCDFXc6VpWTd9CSX0ZJ6PRIikgnWVUkozNkMHk-8y-KdRx8QHE6W2VuQfjZHTktQtI9BUGd3_gy78GFzeLlMtJbSiGZ0hOlEy-BiD7vkymEGEV06Af4bEp5B4Dol_hcRXWcQmUcywe9Dh1_of1QctH5gP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2492125269</pqid></control><display><type>article</type><title>Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial</title><source>Springer Nature - Complete Springer Journals</source><creator>Li, Shanshan ; Mi, Baibing ; Qu, Pengfei ; Liu, Danmeng ; Lei, Fangliang ; Wang, Duolao ; Zeng, Lingxia ; Kang, Yijun ; Shen, Yuan ; Pei, Leilei ; Zhu, Zhonghai ; Yan, Hong ; Liu, Xin ; Dang, Shaonong</creator><creatorcontrib>Li, Shanshan ; Mi, Baibing ; Qu, Pengfei ; Liu, Danmeng ; Lei, Fangliang ; Wang, Duolao ; Zeng, Lingxia ; Kang, Yijun ; Shen, Yuan ; Pei, Leilei ; Zhu, Zhonghai ; Yan, Hong ; Liu, Xin ; Dang, Shaonong</creatorcontrib><description>Purpose
Evidence about the effect of maternal vitamin B
12
supplementation on offspring’s vitamin B
12
status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B
12
status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B
12
, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates.
Results
Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B
12
(
P
= 0.001) and lower homocysteine concentrations (
P
= 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B
12
concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (
P
interaction
= 0.060).
Conclusions
Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B
12
status in rural northwest China.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-020-02309-x</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Chemistry ; Chemistry and Materials Science ; Clinical trials ; Cord blood ; Folic acid ; Gestation ; Homocysteine ; Neonates ; Newborn babies ; Nutrition ; Original Contribution ; Supplements ; Vitamin B ; Vitamin B12</subject><ispartof>European journal of nutrition, 2021-03, Vol.60 (2), p.1031-1039</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267x-103d74a059b81bd27bdbf33ac74a1aa8d8de2467f4040f1800711c2a3b5ddde33</citedby><cites>FETCH-LOGICAL-c267x-103d74a059b81bd27bdbf33ac74a1aa8d8de2467f4040f1800711c2a3b5ddde33</cites><orcidid>0000-0001-5105-0532</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-020-02309-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-020-02309-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Mi, Baibing</creatorcontrib><creatorcontrib>Qu, Pengfei</creatorcontrib><creatorcontrib>Liu, Danmeng</creatorcontrib><creatorcontrib>Lei, Fangliang</creatorcontrib><creatorcontrib>Wang, Duolao</creatorcontrib><creatorcontrib>Zeng, Lingxia</creatorcontrib><creatorcontrib>Kang, Yijun</creatorcontrib><creatorcontrib>Shen, Yuan</creatorcontrib><creatorcontrib>Pei, Leilei</creatorcontrib><creatorcontrib>Zhu, Zhonghai</creatorcontrib><creatorcontrib>Yan, Hong</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Dang, Shaonong</creatorcontrib><title>Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><description>Purpose
Evidence about the effect of maternal vitamin B
12
supplementation on offspring’s vitamin B
12
status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B
12
status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B
12
, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates.
Results
Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B
12
(
P
= 0.001) and lower homocysteine concentrations (
P
= 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B
12
concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (
P
interaction
= 0.060).
Conclusions
Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B
12
status in rural northwest China.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Clinical trials</subject><subject>Cord blood</subject><subject>Folic acid</subject><subject>Gestation</subject><subject>Homocysteine</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Supplements</subject><subject>Vitamin B</subject><subject>Vitamin B12</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctOBCEQRYnRRB39AVckbty0FtCPaXdqfCUmbnRNaKCVCQ0j0Dr6FX6yaBtNXLioVIWce1PURWiPwCEBaI4iAGvLAijkYtAWqzW0RUpWFzUl1frPDM0m2o5xAZCxmmyh95MYvTQiGe-w77FwSTuRhMXPJonBOHyKpR-WVq9wHJe5D9qlCX8x6RE77f_whOKYiTEeY_1slHZS4z74AQss7RiTDjgIp_xg3rTK5i4Fb20eUzDC7qCNXtiod7_7DN1fnN-dXRU3t5fXZyc3haR1syoIMNWUAqq2m5NO0aZTXc-YkPmRCDFXc6VpWTd9CSX0ZJ6PRIikgnWVUkozNkMHk-8y-KdRx8QHE6W2VuQfjZHTktQtI9BUGd3_gy78GFzeLlMtJbSiGZ0hOlEy-BiD7vkymEGEV06Af4bEp5B4Dol_hcRXWcQmUcywe9Dh1_of1QctH5gP</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Li, Shanshan</creator><creator>Mi, Baibing</creator><creator>Qu, Pengfei</creator><creator>Liu, Danmeng</creator><creator>Lei, Fangliang</creator><creator>Wang, Duolao</creator><creator>Zeng, Lingxia</creator><creator>Kang, Yijun</creator><creator>Shen, Yuan</creator><creator>Pei, Leilei</creator><creator>Zhu, Zhonghai</creator><creator>Yan, Hong</creator><creator>Liu, Xin</creator><creator>Dang, Shaonong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5105-0532</orcidid></search><sort><creationdate>20210301</creationdate><title>Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial</title><author>Li, Shanshan ; Mi, Baibing ; Qu, Pengfei ; Liu, Danmeng ; Lei, Fangliang ; Wang, Duolao ; Zeng, Lingxia ; Kang, Yijun ; Shen, Yuan ; Pei, Leilei ; Zhu, Zhonghai ; Yan, Hong ; Liu, Xin ; Dang, Shaonong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267x-103d74a059b81bd27bdbf33ac74a1aa8d8de2467f4040f1800711c2a3b5ddde33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Clinical trials</topic><topic>Cord blood</topic><topic>Folic acid</topic><topic>Gestation</topic><topic>Homocysteine</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Supplements</topic><topic>Vitamin B</topic><topic>Vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Mi, Baibing</creatorcontrib><creatorcontrib>Qu, Pengfei</creatorcontrib><creatorcontrib>Liu, Danmeng</creatorcontrib><creatorcontrib>Lei, Fangliang</creatorcontrib><creatorcontrib>Wang, Duolao</creatorcontrib><creatorcontrib>Zeng, Lingxia</creatorcontrib><creatorcontrib>Kang, Yijun</creatorcontrib><creatorcontrib>Shen, Yuan</creatorcontrib><creatorcontrib>Pei, Leilei</creatorcontrib><creatorcontrib>Zhu, Zhonghai</creatorcontrib><creatorcontrib>Yan, Hong</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Dang, Shaonong</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shanshan</au><au>Mi, Baibing</au><au>Qu, Pengfei</au><au>Liu, Danmeng</au><au>Lei, Fangliang</au><au>Wang, Duolao</au><au>Zeng, Lingxia</au><au>Kang, Yijun</au><au>Shen, Yuan</au><au>Pei, Leilei</au><au>Zhu, Zhonghai</au><au>Yan, Hong</au><au>Liu, Xin</au><au>Dang, Shaonong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><date>2021-03-01</date><risdate>2021</risdate><volume>60</volume><issue>2</issue><spage>1031</spage><epage>1039</epage><pages>1031-1039</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Evidence about the effect of maternal vitamin B
12
supplementation on offspring’s vitamin B
12
status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B
12
status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B
12
, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates.
Results
Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B
12
(
P
= 0.001) and lower homocysteine concentrations (
P
= 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B
12
concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (
P
interaction
= 0.060).
Conclusions
Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B
12
status in rural northwest China.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00394-020-02309-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5105-0532</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2021-03, Vol.60 (2), p.1031-1039 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2416931075 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Chemistry Chemistry and Materials Science Clinical trials Cord blood Folic acid Gestation Homocysteine Neonates Newborn babies Nutrition Original Contribution Supplements Vitamin B Vitamin B12 |
| title | Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial |
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