Ouabain and Marinobufagenin: Physiological Effects on Human Epithelial and Endothelial Cells

Long-term study on the identification of Na,K-ATPase endogenous inhibitors in mammalian tissues has resulted in the discovery of ouabain, marinobufagenin (MBG), and other cardiotonic steroids (CTS) in the blood plasma. Production of ouabain and MBG is increased in essential hypertension and other di...

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Veröffentlicht in:	Biochemistry (Moscow) 2020-04, Vol.85 (4), p.507-515
Hauptverfasser:	Klimanova, E. A., Fedorov, D. A., Sidorenko, S. V., Abramicheva, P. A., Lopina, O. D., Orlov, S. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Blood plasma Bufanolides - pharmacology Cardiotonic Agents - pharmacology Cell Death Cell Proliferation Cells, Cultured Deoxyribonucleic acid DNA DNA biosynthesis Endothelial cells Endothelial Cells - drug effects Endothelial Cells - physiology Epithelial cells Epithelial Cells - drug effects Epithelial Cells - physiology Glycocalyx Heart - drug effects Heart - physiology Humans Hypertension Hypervolemia Influence Ion Transport Life Sciences Microbiology Na+/K+-exchanging ATPase Ouabain Ouabain - pharmacology Physiological aspects Physiological effects Physiology Rubidium Serum-free medium Steroid hormones Steroids Synthesis Thymidine Umbilical vein Vasoconstrictor Agents - pharmacology
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