Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis
Objectives To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children. Methods Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study....
Gespeichert in:
| Veröffentlicht in: | Indian journal of pediatrics 2021-02, Vol.88 (2), p.134-140 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | 2 |
| container_start_page | 134 |
| container_title | Indian journal of pediatrics |
| container_volume | 88 |
| creator | Şen, Semra Kamit, Fulya İşgüder, Rana Yazıcı, Pınar Bal, Zümrüt Şahbudak Devrim, İlker Bayram, S. Nuri Karapınar, Bülent Anıl, Ayşe Berna Vardar, Fadıl |
| description | Objectives
To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children.
Methods
Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis.
Results
Of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. The median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (
p
= 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (
p
= 0.075)].
Conclusions
Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis. |
| doi_str_mv | 10.1007/s12098-020-03355-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2416273950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2416273950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-fa6a6751e698e28e2195e14d861de40e5ad163ccd09314d93974dcecf79f25773</originalsourceid><addsrcrecordid>eNp9kM9OAyEQh4nRWK2-gAezRy_oAAuUi4k29U9SY2PrmSA722xtdyt0D75Nn6VPJtrq0YQEMnzzy8xHyBmDSwagryLjYHoUOFAQQkoq9sgRGC2oVkbspzcwQ2UuVYccxzgD4AaUOSQdwaXmiTki1-M2lM7jZj15GTxRlrm4WbtsFJpp3cRV5bPbqlm48I4hq-pshEXlViGVx7iMVTwhB6WbRzzd3V3yejeY9B_o8Pn-sX8zpF7kekVLp5zSkqEyPeTpMCOR5UVPsQJzQOkKpoT3BRiRykYYnRcefalNmUbVoksutrnL0Hy0GFd2UUWP87mrsWmj5TlTXAsjIaF8i_rQxBiwtMtQpQ0-LQP77c1uvdnkzf54syI1ne_y27cFFn8tv6ISILZATF_1FIOdNW2o087_xX4BO0h4JQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2416273950</pqid></control><display><type>article</type><title>Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Şen, Semra ; Kamit, Fulya ; İşgüder, Rana ; Yazıcı, Pınar ; Bal, Zümrüt Şahbudak ; Devrim, İlker ; Bayram, S. Nuri ; Karapınar, Bülent ; Anıl, Ayşe Berna ; Vardar, Fadıl</creator><creatorcontrib>Şen, Semra ; Kamit, Fulya ; İşgüder, Rana ; Yazıcı, Pınar ; Bal, Zümrüt Şahbudak ; Devrim, İlker ; Bayram, S. Nuri ; Karapınar, Bülent ; Anıl, Ayşe Berna ; Vardar, Fadıl</creatorcontrib><description>Objectives
To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children.
Methods
Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis.
Results
Of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. The median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (
p
= 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (
p
= 0.075)].
Conclusions
Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis.</description><identifier>ISSN: 0019-5456</identifier><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/s12098-020-03355-3</identifier><identifier>PMID: 32572693</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adolescent ; Biomarkers ; Child ; Child, Preschool ; Gynecology ; Humans ; Infant ; Intensive Care Units, Pediatric ; Medicine ; Medicine & Public Health ; Original Article ; Pediatrics ; Prognosis ; Sepsis - diagnosis ; Shock, Septic - diagnosis ; Triggering Receptor Expressed on Myeloid Cells-1 - analysis</subject><ispartof>Indian journal of pediatrics, 2021-02, Vol.88 (2), p.134-140</ispartof><rights>Dr. K C Chaudhuri Foundation 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-fa6a6751e698e28e2195e14d861de40e5ad163ccd09314d93974dcecf79f25773</citedby><cites>FETCH-LOGICAL-c347t-fa6a6751e698e28e2195e14d861de40e5ad163ccd09314d93974dcecf79f25773</cites><orcidid>0000-0003-2960-1793</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12098-020-03355-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12098-020-03355-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32572693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şen, Semra</creatorcontrib><creatorcontrib>Kamit, Fulya</creatorcontrib><creatorcontrib>İşgüder, Rana</creatorcontrib><creatorcontrib>Yazıcı, Pınar</creatorcontrib><creatorcontrib>Bal, Zümrüt Şahbudak</creatorcontrib><creatorcontrib>Devrim, İlker</creatorcontrib><creatorcontrib>Bayram, S. Nuri</creatorcontrib><creatorcontrib>Karapınar, Bülent</creatorcontrib><creatorcontrib>Anıl, Ayşe Berna</creatorcontrib><creatorcontrib>Vardar, Fadıl</creatorcontrib><title>Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis</title><title>Indian journal of pediatrics</title><addtitle>Indian J Pediatr</addtitle><addtitle>Indian J Pediatr</addtitle><description>Objectives
To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children.
Methods
Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis.
Results
Of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. The median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (
p
= 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (
p
= 0.075)].
Conclusions
Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis.</description><subject>Adolescent</subject><subject>Biomarkers</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive Care Units, Pediatric</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Sepsis - diagnosis</subject><subject>Shock, Septic - diagnosis</subject><subject>Triggering Receptor Expressed on Myeloid Cells-1 - analysis</subject><issn>0019-5456</issn><issn>0973-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9OAyEQh4nRWK2-gAezRy_oAAuUi4k29U9SY2PrmSA722xtdyt0D75Nn6VPJtrq0YQEMnzzy8xHyBmDSwagryLjYHoUOFAQQkoq9sgRGC2oVkbspzcwQ2UuVYccxzgD4AaUOSQdwaXmiTki1-M2lM7jZj15GTxRlrm4WbtsFJpp3cRV5bPbqlm48I4hq-pshEXlViGVx7iMVTwhB6WbRzzd3V3yejeY9B_o8Pn-sX8zpF7kekVLp5zSkqEyPeTpMCOR5UVPsQJzQOkKpoT3BRiRykYYnRcefalNmUbVoksutrnL0Hy0GFd2UUWP87mrsWmj5TlTXAsjIaF8i_rQxBiwtMtQpQ0-LQP77c1uvdnkzf54syI1ne_y27cFFn8tv6ISILZATF_1FIOdNW2o087_xX4BO0h4JQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Şen, Semra</creator><creator>Kamit, Fulya</creator><creator>İşgüder, Rana</creator><creator>Yazıcı, Pınar</creator><creator>Bal, Zümrüt Şahbudak</creator><creator>Devrim, İlker</creator><creator>Bayram, S. Nuri</creator><creator>Karapınar, Bülent</creator><creator>Anıl, Ayşe Berna</creator><creator>Vardar, Fadıl</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2960-1793</orcidid></search><sort><creationdate>20210201</creationdate><title>Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis</title><author>Şen, Semra ; Kamit, Fulya ; İşgüder, Rana ; Yazıcı, Pınar ; Bal, Zümrüt Şahbudak ; Devrim, İlker ; Bayram, S. Nuri ; Karapınar, Bülent ; Anıl, Ayşe Berna ; Vardar, Fadıl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-fa6a6751e698e28e2195e14d861de40e5ad163ccd09314d93974dcecf79f25773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Biomarkers</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive Care Units, Pediatric</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Sepsis - diagnosis</topic><topic>Shock, Septic - diagnosis</topic><topic>Triggering Receptor Expressed on Myeloid Cells-1 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şen, Semra</creatorcontrib><creatorcontrib>Kamit, Fulya</creatorcontrib><creatorcontrib>İşgüder, Rana</creatorcontrib><creatorcontrib>Yazıcı, Pınar</creatorcontrib><creatorcontrib>Bal, Zümrüt Şahbudak</creatorcontrib><creatorcontrib>Devrim, İlker</creatorcontrib><creatorcontrib>Bayram, S. Nuri</creatorcontrib><creatorcontrib>Karapınar, Bülent</creatorcontrib><creatorcontrib>Anıl, Ayşe Berna</creatorcontrib><creatorcontrib>Vardar, Fadıl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şen, Semra</au><au>Kamit, Fulya</au><au>İşgüder, Rana</au><au>Yazıcı, Pınar</au><au>Bal, Zümrüt Şahbudak</au><au>Devrim, İlker</au><au>Bayram, S. Nuri</au><au>Karapınar, Bülent</au><au>Anıl, Ayşe Berna</au><au>Vardar, Fadıl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis</atitle><jtitle>Indian journal of pediatrics</jtitle><stitle>Indian J Pediatr</stitle><addtitle>Indian J Pediatr</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>88</volume><issue>2</issue><spage>134</spage><epage>140</epage><pages>134-140</pages><issn>0019-5456</issn><eissn>0973-7693</eissn><abstract>Objectives
To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children.
Methods
Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis.
Results
Of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. The median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (
p
= 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (
p
= 0.075)].
Conclusions
Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>32572693</pmid><doi>10.1007/s12098-020-03355-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2960-1793</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-5456 |
| ispartof | Indian journal of pediatrics, 2021-02, Vol.88 (2), p.134-140 |
| issn | 0019-5456 0973-7693 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2416273950 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Biomarkers Child Child, Preschool Gynecology Humans Infant Intensive Care Units, Pediatric Medicine Medicine & Public Health Original Article Pediatrics Prognosis Sepsis - diagnosis Shock, Septic - diagnosis Triggering Receptor Expressed on Myeloid Cells-1 - analysis |
| title | Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T09%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Surface%C2%A0TREM-1%20as%C2%A0a%20Prognostic%20Biomarker%20in%20Pediatric%20Sepsis&rft.jtitle=Indian%20journal%20of%20pediatrics&rft.au=%C5%9Een,%20Semra&rft.date=2021-02-01&rft.volume=88&rft.issue=2&rft.spage=134&rft.epage=140&rft.pages=134-140&rft.issn=0019-5456&rft.eissn=0973-7693&rft_id=info:doi/10.1007/s12098-020-03355-3&rft_dat=%3Cproquest_cross%3E2416273950%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2416273950&rft_id=info:pmid/32572693&rfr_iscdi=true |