SDCBP/MDA-9/syntenin phosphorylation by AURKA promotes esophageal squamous cell carcinoma progression through the EGFR-PI3K-Akt signaling pathway

SDCBP is an adapter protein containing two tandem PDZ domains mediating cell adhesion. The role and underlying molecular mechanism of SDCBP in ESCC remain obscure. Here, we report that SDCBP is frequently overexpressed in ESCC tissues and cells compared to normal controls and that its overexpression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2020-07, Vol.39 (31), p.5405-5419
Hauptverfasser:	Du, Ruijuan, Huang, Chuntian, Chen, Hanyong, Liu, Kangdong, Xiang, Pu, Yao, Ning, Yang, Lu, Zhou, Liting, Wu, Qiong, Zheng, Yaqiu, Xin, Mingxia, Dong, Zigang, Li, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/1 13/105 13/109 13/31 13/51 14/19 38/77 631/337/458/1733 631/67/395 82/29 82/83 96 Adapter proteins AKT protein Apoptosis Cell adhesion Cell adhesion & migration Cell Biology Comparative analysis Development and progression Disease Progression Epidermal growth factor receptors ErbB Receptors - metabolism Esophageal cancer Esophageal Squamous Cell Carcinoma - genetics Esophagus Female Health aspects Human Genetics Humans Internal Medicine Internalization Kinases Male Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Prognosis Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Squamous cell carcinoma Syntenins - genetics Therapeutic applications Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!