α-Synuclein Overexpression in SH-SY5Y Human Neuroblastoma Cells Leads to the Accumulation of Thioflavin S-positive Aggregates and Impairment of Glycolysis

Deterioration of energy metabolism in affected cells is an important feature of synucleinopathies, including Parkinson's disease. Here, we studied the association between α-synuclein accumulation and glycolysis using SH-SY5Y neuroblastoma cell lines stably expressing wild-type α-synuclein or it...

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Veröffentlicht in:	Biochemistry (Moscow) 2020-05, Vol.85 (5), p.604-613
Hauptverfasser:	Melnikova, A., Pozdyshev, D., Barinova, K., Kudryavtseva, S., Muronetz, V. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aggregates alpha-Synuclein - genetics alpha-Synuclein - metabolism Amyloid - metabolism Benzothiazoles - chemistry Benzothiazoles - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cell Line, Tumor Cell lines Deactivation Energy metabolism Glucose Glucose metabolism Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Glycolysis Humans Inactivation Lactic acid Life Sciences Metabolism Microbiology Movement disorders Neuroblastoma Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblasts Neurodegenerative diseases Oxidation-Reduction Parkinson's disease Proteins Synuclein
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