Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (po...
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| Veröffentlicht in: | Journal of molecular neuroscience 2021, Vol.71 (1), p.28-41 |
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| creator | Vinay, Ponnusamy Karen, Christopher Balamurugan, Krishnaswamy Rajan, Koilmani Emmanuvel |
| description | This study was designed to test whether the
Cronobacter sakazakii
infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (postnatal day, PND 15) were treated with either
C. sakazakii
(10
7
CFU) or
Escherichia coli
OP50 (10
7
CFU) or Luria bertani broth (100 μL) through oral gavage and allowed to stay with their mothers until PND 24. Experimental groups’ rats were allowed to explore (PNDs 31–35) and then trained in contextual learning task (PNDs 36–43). Five days after training, individuals were tested for memory retention (PNDs 49–56). Observed behavioural data showed that
C. sakazakii
infection impaired contextual-associative learning and memory. Furthermore, our analysis showed that
C. sakazakii
infection activates complement system complement anaphylatoxin (C5a) (a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1)) and mitogen-activated protein kinase kinase1 (MEKK1). Subsequently, MEKK1 induces pro-inflammatory signals possibly through apoptosis signal-regulating kinase-1 (ASK-1), c-Jun N-terminal kinase (JNK1/3) and protein kinase B gamma (AKT-3). In parallel, activated nuclear factor kappa-light-chain-enhancer B cells (NF-κB) induces interleukin-6 (IL-6) and IFNα-1, which may alter the level of serotonin transporter (SERT). Observed results suggest that impaired contextual learning and memory could be correlated with C5a-mediated NF-κβ and ASK1 pathways. |
| doi_str_mv | 10.1007/s12031-020-01622-8 |
| format | Article |
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Cronobacter sakazakii
infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (postnatal day, PND 15) were treated with either
C. sakazakii
(10
7
CFU) or
Escherichia coli
OP50 (10
7
CFU) or Luria bertani broth (100 μL) through oral gavage and allowed to stay with their mothers until PND 24. Experimental groups’ rats were allowed to explore (PNDs 31–35) and then trained in contextual learning task (PNDs 36–43). Five days after training, individuals were tested for memory retention (PNDs 49–56). Observed behavioural data showed that
C. sakazakii
infection impaired contextual-associative learning and memory. Furthermore, our analysis showed that
C. sakazakii
infection activates complement system complement anaphylatoxin (C5a) (a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1)) and mitogen-activated protein kinase kinase1 (MEKK1). Subsequently, MEKK1 induces pro-inflammatory signals possibly through apoptosis signal-regulating kinase-1 (ASK-1), c-Jun N-terminal kinase (JNK1/3) and protein kinase B gamma (AKT-3). In parallel, activated nuclear factor kappa-light-chain-enhancer B cells (NF-κB) induces interleukin-6 (IL-6) and IFNα-1, which may alter the level of serotonin transporter (SERT). Observed results suggest that impaired contextual learning and memory could be correlated with C5a-mediated NF-κβ and ASK1 pathways.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-020-01622-8</identifier><identifier>PMID: 32567007</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ADAM protein ; ADAMTS-1 protein ; AKT protein ; Alternations ; Anaphylatoxins ; Apoptosis ; Associative learning ; Associative memory ; Biomedical and Life Sciences ; Biomedicine ; c-Jun protein ; Cell Biology ; Cognitive tasks ; Complement ; Complement activation ; Complement component C5a ; Cronobacter sakazakii ; E coli ; Infections ; Inflammation ; Interleukin 6 ; JNK protein ; Kinases ; Learning ; Lymphocytes B ; MAP kinase ; Neurochemistry ; Neurology ; Neurosciences ; NF-κB protein ; Proteins ; Proteomics ; Rodents ; Sepsis ; Serotonin ; Serotonin transporter ; Thrombospondin ; Transcription factors ; α-Interferon</subject><ispartof>Journal of molecular neuroscience, 2021, Vol.71 (1), p.28-41</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3568-57f06cf501e2c41d7650ecc2a1f6c3e78ff0da1e89c1832306e4bbe02b7aba093</citedby><cites>FETCH-LOGICAL-c3568-57f06cf501e2c41d7650ecc2a1f6c3e78ff0da1e89c1832306e4bbe02b7aba093</cites><orcidid>0000-0003-2804-8594</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-020-01622-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-020-01622-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32567007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vinay, Ponnusamy</creatorcontrib><creatorcontrib>Karen, Christopher</creatorcontrib><creatorcontrib>Balamurugan, Krishnaswamy</creatorcontrib><creatorcontrib>Rajan, Koilmani Emmanuvel</creatorcontrib><title>Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>This study was designed to test whether the
Cronobacter sakazakii
infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (postnatal day, PND 15) were treated with either
C. sakazakii
(10
7
CFU) or
Escherichia coli
OP50 (10
7
CFU) or Luria bertani broth (100 μL) through oral gavage and allowed to stay with their mothers until PND 24. Experimental groups’ rats were allowed to explore (PNDs 31–35) and then trained in contextual learning task (PNDs 36–43). Five days after training, individuals were tested for memory retention (PNDs 49–56). Observed behavioural data showed that
C. sakazakii
infection impaired contextual-associative learning and memory. Furthermore, our analysis showed that
C. sakazakii
infection activates complement system complement anaphylatoxin (C5a) (a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1)) and mitogen-activated protein kinase kinase1 (MEKK1). Subsequently, MEKK1 induces pro-inflammatory signals possibly through apoptosis signal-regulating kinase-1 (ASK-1), c-Jun N-terminal kinase (JNK1/3) and protein kinase B gamma (AKT-3). In parallel, activated nuclear factor kappa-light-chain-enhancer B cells (NF-κB) induces interleukin-6 (IL-6) and IFNα-1, which may alter the level of serotonin transporter (SERT). Observed results suggest that impaired contextual learning and memory could be correlated with C5a-mediated NF-κβ and ASK1 pathways.</description><subject>ADAM protein</subject><subject>ADAMTS-1 protein</subject><subject>AKT protein</subject><subject>Alternations</subject><subject>Anaphylatoxins</subject><subject>Apoptosis</subject><subject>Associative learning</subject><subject>Associative memory</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>c-Jun protein</subject><subject>Cell Biology</subject><subject>Cognitive tasks</subject><subject>Complement</subject><subject>Complement activation</subject><subject>Complement component C5a</subject><subject>Cronobacter sakazakii</subject><subject>E coli</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>Learning</subject><subject>Lymphocytes B</subject><subject>MAP kinase</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>NF-κB protein</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Rodents</subject><subject>Sepsis</subject><subject>Serotonin</subject><subject>Serotonin transporter</subject><subject>Thrombospondin</subject><subject>Transcription factors</subject><subject>α-Interferon</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1u1DAUgCMEotPCBVggS2zYGPwTOw67UdTCiAFGBdbRi_NS0mbsqe1Ah6NwDJYcomciJQUkFqws2d_7_KQvyx5x9owzVjyPXDDJKROMMq6FoOZOtuBKlZRzre9mC2ZKRY0u9UF2GOM5Y4Ln3NzPDqRQupgUi-xbFbzzDdiEgUS4gK9w0fdk5Tq0qfeO9I4cQxj2ZONjcpBgIKeQIlltd9AHbEnlXcKrNMJAlzF620OabtcIwfXu7AUBshkTpP4zklM_IPEdqRTQN9jO5NsTev3j-jsB15Ll-9ecbCB9-gL7-CC718EQ8eHteZR9PDn-UL2i63cvV9VyTa1U2lBVdEzbTjGOwua8LbRiaK0A3mkrsTBdx1rgaErLjRSSacybBploCmiAlfIoezp7d8FfjhhTve2jxWEAh36Mtci5MrJghZrQJ_-g534MbtpuogopS5GLG6GYKRt8jAG7ehf6LYR9zVl9U66ey9VTufpXudpMQ49v1WOzxfbPyO9UEyBnIE5P7gzD37__o_0JLn-lQg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Vinay, Ponnusamy</creator><creator>Karen, Christopher</creator><creator>Balamurugan, Krishnaswamy</creator><creator>Rajan, Koilmani Emmanuvel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2804-8594</orcidid></search><sort><creationdate>2021</creationdate><title>Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways</title><author>Vinay, Ponnusamy ; Karen, Christopher ; Balamurugan, Krishnaswamy ; Rajan, Koilmani Emmanuvel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3568-57f06cf501e2c41d7650ecc2a1f6c3e78ff0da1e89c1832306e4bbe02b7aba093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ADAM protein</topic><topic>ADAMTS-1 protein</topic><topic>AKT protein</topic><topic>Alternations</topic><topic>Anaphylatoxins</topic><topic>Apoptosis</topic><topic>Associative learning</topic><topic>Associative memory</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>c-Jun protein</topic><topic>Cell Biology</topic><topic>Cognitive tasks</topic><topic>Complement</topic><topic>Complement activation</topic><topic>Complement component C5a</topic><topic>Cronobacter sakazakii</topic><topic>E coli</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>Learning</topic><topic>Lymphocytes B</topic><topic>MAP kinase</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>NF-κB protein</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Rodents</topic><topic>Sepsis</topic><topic>Serotonin</topic><topic>Serotonin transporter</topic><topic>Thrombospondin</topic><topic>Transcription factors</topic><topic>α-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vinay, Ponnusamy</creatorcontrib><creatorcontrib>Karen, Christopher</creatorcontrib><creatorcontrib>Balamurugan, Krishnaswamy</creatorcontrib><creatorcontrib>Rajan, Koilmani Emmanuvel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vinay, Ponnusamy</au><au>Karen, Christopher</au><au>Balamurugan, Krishnaswamy</au><au>Rajan, Koilmani Emmanuvel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2021</date><risdate>2021</risdate><volume>71</volume><issue>1</issue><spage>28</spage><epage>41</epage><pages>28-41</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>This study was designed to test whether the
Cronobacter sakazakii
infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat pups (postnatal day, PND 15) were treated with either
C. sakazakii
(10
7
CFU) or
Escherichia coli
OP50 (10
7
CFU) or Luria bertani broth (100 μL) through oral gavage and allowed to stay with their mothers until PND 24. Experimental groups’ rats were allowed to explore (PNDs 31–35) and then trained in contextual learning task (PNDs 36–43). Five days after training, individuals were tested for memory retention (PNDs 49–56). Observed behavioural data showed that
C. sakazakii
infection impaired contextual-associative learning and memory. Furthermore, our analysis showed that
C. sakazakii
infection activates complement system complement anaphylatoxin (C5a) (a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1)) and mitogen-activated protein kinase kinase1 (MEKK1). Subsequently, MEKK1 induces pro-inflammatory signals possibly through apoptosis signal-regulating kinase-1 (ASK-1), c-Jun N-terminal kinase (JNK1/3) and protein kinase B gamma (AKT-3). In parallel, activated nuclear factor kappa-light-chain-enhancer B cells (NF-κB) induces interleukin-6 (IL-6) and IFNα-1, which may alter the level of serotonin transporter (SERT). Observed results suggest that impaired contextual learning and memory could be correlated with C5a-mediated NF-κβ and ASK1 pathways.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32567007</pmid><doi>10.1007/s12031-020-01622-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2804-8594</orcidid></addata></record> |
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| ispartof | Journal of molecular neuroscience, 2021, Vol.71 (1), p.28-41 |
| issn | 0895-8696 1559-1166 |
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| subjects | ADAM protein ADAMTS-1 protein AKT protein Alternations Anaphylatoxins Apoptosis Associative learning Associative memory Biomedical and Life Sciences Biomedicine c-Jun protein Cell Biology Cognitive tasks Complement Complement activation Complement component C5a Cronobacter sakazakii E coli Infections Inflammation Interleukin 6 JNK protein Kinases Learning Lymphocytes B MAP kinase Neurochemistry Neurology Neurosciences NF-κB protein Proteins Proteomics Rodents Sepsis Serotonin Serotonin transporter Thrombospondin Transcription factors α-Interferon |
| title | Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways |
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